C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

α-Synuclein Locus Triplication Causes Parkinson's Disease

2003 • 4,187 citations

α-synuclein locus duplication as a cause of familial Parkinson's disease

2004 • 1,929 citations

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

2001 • 1,892 citations

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

2004 • 1,337 citations

α-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models

2006 • 1,328 citations

Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease

2002 • 1,220 citations

Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease

2007 • 1,022 citations

The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

2002 • 790 citations

Substrate-specific Activation of Sirtuins by Resveratrol

2005 • 736 citations

Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans.

1995 • 643 citations

Environmental risk factors and Parkinson's disease

1997 • 605 citations

α-Synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

2005 • 600 citations

The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis

2007 • 506 citations

The α‐Synucleinopathies: Parkinson's Disease, Dementia with Lewy Bodies, and Multiple System Atrophy

2000 • 486 citations

Lipid Droplet Binding and Oligomerization Properties of the Parkinson's Disease Protein α-Synuclein

2002 • 429 citations

Stress management – heat shock protein-70 and the regulation of apoptosis

2001 • 428 citations

Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or α-Synuclein

2003 • 427 citations

Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation

2004 • 414 citations

A Role for SIR-2.1 Regulation of ER Stress Response Genes in Determining C. elegans Life Span

2005 • 399 citations

Polyglutamine protein aggregates are dynamic

2002 • 297 citations

Parkinson's disease: A case‐control study of occupational and environmental risk factors

1990 • 292 citations

α-Synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease

2005 • 201 citations

Genes determining yeast replicative life span in a long-lived genetic background

2005 • 165 citations

Ultrastructural observations in Parkinsonism

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Quantitative electroencephalogram analysis in dementia with Lewy bodies and Alzheimer's disease

2005 • 84 citations

Homologous gene targeting in Caenorhabditis elegans by biolistic transformation

2004 • 84 citations

The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL

2000 • 70 citations

Synaptophysin and chromogranin A immunoreactivities of Lewy bodies in Parkinson's disease brains

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Nicotine induces brain CYP enzymes: relevance to Parkinson’s disease

2006 • 64 citations

Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality

2004 • 58 citations