Macrophages and neoplasms: new insights and their implication in tumor immunobiology

Immunobiology of the Macrophage

1976 • 622 citations

Endotoxin and Double Stranded RNA render Macrophages Cytotoxic

1971 • 448 citations

Macrophage content of tumours in relation to metastatic spread and host immune reaction

1974 • 380 citations

Induction of fibroblast chemotaxis by fibronectin. Localization of the chemotactic region to a 140,000-molecular weight non-gelatin-binding fragment.

1981 • 372 citations

Eradication of spontaneous metastases and activation of alveolar macrophages by intravenous injection of liposomes containing muramyl dipeptide.

1981 • 322 citations

Role of prostaglandin endoperoxide PGG2 in inflammatory processes

1977 • 307 citations

MACROPHAGES IN SYNGENEIC ANIMAL TUMOURS

1972 • 295 citations

Macrophage-mediated tumor cell killing: regulation of expression of cytolytic activity by prostaglandin E.

1981 • 238 citations

Prostaglandins, macrophages, and immunity.

1980 • 238 citations

Prostaglandin regulation of macrophage collagenase production.

1977 • 230 citations

The reticuloendothelial system: A comprehensive treatise

1984 • 224 citations

Regulation of Macrophage Tumoricidal Function: A Role for Prostaglandins of the E Series

1978 • 214 citations

Macrophage production of fibronectin, a chemoattractant for fibroblasts.

1981 • 211 citations

Involvement of macrophages in the eradication of established metastases following intravenous injection of liposomes containing macrophage activators.

1982 • 194 citations

Pharmacological control of prostaglandin and thromboxane release from macrophages

1978 • 187 citations

Requirement for vasoactive amines for production of delayed-type hypersensitvity skin reactions.

1975 • 186 citations

Relationship of bone destruction in skeletal metastases to osteoclast activation and prostaglandins

1976 • 183 citations

Antiinflammatory Effects of Murine Malignant Cells

1974 • 183 citations

Design of liposomes to improve delivery of macrophage-augmenting agents to alveolar macrophages.

1980 • 180 citations

An Inhibitor of Macrophage Chemotaxis Produced by Neoplasms

1976 • 165 citations

Depression of macrophage function by a factor produced by neoplasms: a merchanism for abrogation of immune surveillance.

1976 • 158 citations

A CHEMOTACTIC ROLE FOR PROSTAGLANDINS RELEASED FROM POLYMORPHONUCLEAR LEUCOCYTES DURING PHAGOCYTOSIS

1975 • 154 citations

Cellular functions in immunity and inflammation

1983 • 145 citations

Effects of Neoplasms on Inflammation: Depression of Macrophage Accumulation after Tumor Implantation

1976 • 137 citations

BREAST CANCER, PROSTAGLANDINS, AND BONE METASTASES

1975 • 136 citations

Similarities of the Anti-tumour Actions of Endotoxin, Lipid A and Double-stranded RNA

1973 • 127 citations

Effects on in vitro tumor growth of murine macrophages isolated from sarcoma lines differing in immunogenicity and metastasizing capacity

1978 • 126 citations

Activation of macrophages

1985 • 124 citations

Do Macrophages Destroy Nascent Tumors?<xref ref-type="fn" rid="FN5">5</xref>

1979 • 119 citations

Arachidonic Acid Transformation and Tumor Production

1981 • 117 citations

Prostaglandin E-mediated mitogenic stimulation of mouse epidermis in vivo by divalent cation ionophore A 23187 and by tumor promoter 12-O-tetradecanoylphorbol-13-acetate.

1981 • 110 citations

Macrophage accumulation in mice is inhibited by low molecular weight products from murine leukemia viruses.

1980 • 110 citations

Depression of Macrophage Function by a Factor Produced by Neoplasms: A Mechanism for Abrogation of Immune Surveillance

1976 • 109 citations

Mechanisms of Extracellular Killing of Nucleated Mammalian Cells by Macrophages

1976 • 100 citations

Enhancement of carcinogenesis by prostaglandins

1978 • 96 citations

Increased Prostaglandin Synthesis by Macrophages from Tumor-Bearing Mice

1979 • 96 citations

Repopulation of γ-irradiated Lewis lung carcinoma by malignant cells and host macrophage progenitors

1978 • 96 citations

Sequestration of Macrophages in Growing Tumours and its Effect on the Immunological Capacity of the Host

1974 • 95 citations

Macrophage content of metastatic and nonmetastatic rodent neoplasms.

1981 • 94 citations

Immunohistologic Evaluation of the Lymphoreticular Infiltrate of Human Central Nervous System Tumors2

1979 • 91 citations

Macrophage nomenclature: where are we going?

1980 • 87 citations

Origin and partial characterization of F_c receptor‐bearing cells found within experimental carcinomas and sarcomas

1975 • 84 citations

Effect of X-irradiation on host-cell infiltration and growth of a murine fibrosarcoma

1977 • 78 citations

Cell-Specific Defect in Monocyte Function During Tumor Growth2

1976 • 77 citations

Cellular Functions in Immunity and Inflammation

1985 • 68 citations

Adriamycin-activated macrophages as tumor growth inhibitors.

1981 • 67 citations

Tumor Surveillance: How Tumors May Resist Macrophage-Mediated Host Defense

1979 • 59 citations

Prostaglandin E and cancer Growth

1980 • 57 citations

IMMUNOPROLIFERATION AND CANCER: A COMMON MACROPHAGE-DERIVED PROMOTER SUBSTANCE

1978 • 56 citations

Characterization of macrophage chemotaxins in tumor cell cultures and comparison with lymphocyte-derived chemotactic factors.

1977 • 55 citations

Macrophage content and immunogenicity of C57BL/6J and BALB/cByJ methylcholanthrene‐induced sarcomas

1980 • 54 citations

Intra‐tumour host cells of transplanted rat neoplasms of different immunogenicity

1977 • 52 citations

Effects of adriamycin and cyclophosphamide treatment on induction of macrophage cytotoxic function in mice.

1979 • 52 citations

Impaired Inflammatory Response in Tumor-Bearing Guinea Pigs

1972 • 48 citations

In Situ Cytotoxic T Cells in a Methylcholanthrene-Induced Tumor

1978 • 44 citations

Enhancement of anti-cancer activity of cytotoxic chemotherapy with protection of normal tissues by inhibition of P.G. synthesis

1978 • 43 citations

Activation of rat alveolar macrophages to the tumoricidal state in the presence of progressively growing pulmonary metastases.

1981 • 42 citations

Concurrent depression of tumor macrophage infiltration and systemic inflammation by progressive cancer growth.

1978 • 41 citations

Stimulation of macrophage prostaglandin and neutral protease production by phorbol esters as a model for the induction of vascular changes associated with tumor promotion.

1980 • 41 citations

Host cells in transplanted murine tumors and their possible relevance to tumor growth.

1979 • 40 citations

Activation of macrophages for tumor cell cytotoxicity: identification of indomethacin sensitive and insensitive pathways.

1981 • 38 citations

Prostaglandins and cancer

1976 • 36 citations

Host response to premalignant mammary tissues.

1972 • 28 citations

Macrophage-Mediated Tumor Cell Killing: Lack of Dependence on the Cyclooxygenase Pathway of Prostaglandin Synthesis

1979 • 27 citations

Macrophages and Resistance to Tumors. IV. Influence of Age on Susceptibility of Mice to Anti-inflammatory and Antimacrophage Effects of Tumor Cell Products23

1980 • 27 citations

Cyclophosphamide-induced changes in the cellular composition of a methylcholanthrene-induced tumor and their relation to bone marrow and blood leukocyte levels.

1980 • 26 citations

Further observations on the effect of cyclophosphamide on intratumor and peripheral leukocyte levels.

1980 • 25 citations

Macrophage accumulation in transplanted tumors is not dependent on host immune responsiveness or presence of tumor-associated rejection antigens.

1981 • 25 citations

DYNAMICS OF LEUKOCYTE MIGRATION INTO THE MOUSE ASCITES TUMOR

1974 • 23 citations

Tumor Cell Threshold Required for Suppression of Macrophage Inflammation 2 3

1978 • 22 citations

POST-MITOTIC AGE OF MONONUCLEAR CELLS MIGRATING INTO TA-3(St) SOLID TUMORS

1977 • 19 citations

Lack of correlation between in vivo rejection of syngeneic fibrosarcomas and in vitro non-specific macrophage cytotoxicity

1978 • 18 citations

Macrophage-Mediated, Antibody-Dependent Destruction of Tumor Cells in DBA/2 Mice: In Vitro Identification of an In Situ Mechanism<xref ref-type="fn" rid="fn2">2</xref>, <xref ref-type="fn" rid="fn3">3</xref>

1981 • 16 citations

Activities of Macrophages Within and Peripheral to the Tumor Mass

1983 • 14 citations

Macrophage accumulation in primary and transplanted tumors growing in C5‐deficient B10.D2/oSn mice

1980 • 12 citations

Enhancement of Tumor Growth by Peritoneal Macrophages of Normal and Tumor-Bearing Mice

1980 • 7 citations

In vitro and in vivo production of chemotactic inhibitors by tumor cells.

1979 • 7 citations

The Role of the Inflammatory Response During Tumor Growth

1982 • 5 citations

Cellular Basis for Regulation of Tumor Growth

1980 • 4 citations

Suppression of Antibody forming Cells by Rat Spleen Macrophages

1980 • 3 citations

Intratumor and peritoneal inflammatory responses in relation to tumor burden and age of mouse.

1982 • 3 citations