Benzoate X Receptors α and β Are Pharmacologically Distinct and Do Not Function as Xenobiotic Receptors

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

2001 • 156,143 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

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Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Current protocols in molecular biology

1988 • 4,543 citations

Nuclear Receptors and Lipid Physiology: Opening the X-Files

2001 • 2,040 citations

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

1998 • 1,535 citations

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

1998 • 1,497 citations

SXR, a novel steroid and xenobioticsensing nuclear receptor

1998 • 903 citations

Identification of a human nuclear receptor defines a new signaling pathway for CYP 3 A induction

1998 • 852 citations

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

2001 • 830 citations

Unique response pathways are established by allosteric interactions among nuclear hormone receptors

1995 • 629 citations

βCatenin Signaling Activity Dissected in the Early Xenopus Embryo: A Novel Antisense Approach

2000 • 523 citations

Orphan Nuclear Receptors: Shifting Endocrinology into Reverse

1999 • 498 citations

Pregnane X Receptor (PXR), Constitutive Androstane Receptor (CAR), and Benzoate X Receptor (BXR) Define Three Pharmacologically Distinct Classes of Nuclear Receptors

2002 • 336 citations

Orphan nuclear receptors—new ligands and new possibilities: Figure 1.

1998 • 301 citations

Evolution of duplicate genes in a tetraploid animal, Xenopus laevis.

1993 • 228 citations

Orphan Nuclear Receptors: The Exotics of Xenobiotics

2001 • 216 citations

Peptide Mimetic HIV Protease Inhibitors Are Ligands for the Orphan Receptor SXR

2001 • 188 citations

Active repression of RAR signaling is required for head formation

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Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology.

1993 • 102 citations

BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites

1998 • 73 citations

Nuclear Orphan Receptors

1998 • 43 citations

A novel nuclear receptor superfamily member inXenopusthat associates with RXR, and shares extensive sequence similarity to the mammalian vitamin D3 receptor

1994 • 33 citations

Molecular Cloning and Functional Characterization of a Novel Nuclear Receptor Similar to an Embryonic Benzoate Receptor BXR

2000 • 15 citations