A Hydrogen Bond in Loop A Is Critical for the Binding and Function of the 5-HT₃ Receptor

Comparative Protein Modelling by Satisfaction of Spatial Restraints

1993 • 12,640 citations

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

2001 • 1,736 citations

Nicotinic Receptors at the Amino Acid Level

2000 • 795 citations

Nicotine and Carbamylcholine Binding to Nicotinic Acetylcholine Receptors as Studied in AChBP Crystal Structures

2004 • 778 citations

Crystal structure of the extracellular domain of nAChR α1 bound to α-bungarotoxin at 1.94 Å resolution

2007 • 395 citations

Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca ²⁺ -binding sites

2002 • 262 citations

Nicotinic Receptor Binding Site Probed with Unnatural Amino Acid Incorporation in Intact Cells

1995 • 227 citations

Anxiety over GABAA receptor structure relieved by AChBP

2002 • 181 citations

Structure of the agonist-binding site of the nicotinic acetylcholine receptor. [3H]acetylcholine mustard identifies residues in the cation-binding subsite.

1991 • 119 citations

Structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine.

2002 • 116 citations

Unnatural Amino Acid Mutagenesis of the GABA_AReceptor Binding Site Residues Reveals a Novel Cation–π Interaction between GABA and β₂Tyr97

2007 • 112 citations

Prediction of 5-HT3 Receptor Agonist-Binding Residues Using Homology Modeling

2003 • 99 citations

The multiple phenotypes of allosteric receptor mutants.

1996 • 98 citations

Tyrosine Residues That Control Binding and Gating in the 5-Hydroxytryptamine₃Receptor Revealed by Unnatural Amino Acid Mutagenesis

2004 • 95 citations

GABAA Receptor β2Tyr97 and Leu99 Line the GABA-binding Site

2002 • 90 citations

Analysis of the Ligand Binding Site of the 5-HT 3 Receptor Using Site Directed Mutagenesis: Importance of Glutamate 106

1997 • 77 citations

Locating an Antagonist in the 5-HT3 Receptor Binding Site Using Modeling and Radioligand Binding

2005 • 74 citations

The Role of Loop 5 in Acetylcholine Receptor Channel Gating

2003 • 63 citations

Dose-response relations for unnatural amino acids at the agonist binding site of the nicotinic acetylcholine receptor: tests with novel side chains and with several agonists.

1996 • 59 citations

Mapping the Agonist Binding Site of the Nicotinic Acetylcholine Receptor

2000 • 51 citations

Binding Interactions of Antagonists with 5‐Hydroxytryptamine_3AReceptor Models

2003 • 49 citations

Chemical-Scale Studies on the Role of a Conserved Aspartate in Preorganizing the Agonist Binding Site of the Nicotinic Acetylcholine Receptor

2006 • 48 citations

A Mutational Analysis of the Acetylcholine Receptor Channel Transmitter Binding Site

1999 • 47 citations

Importance of phenylalanine 107 in agonist recognition by the 5-hydroxytryptamine(3A) receptor.

2000 • 45 citations

Defining the roles of Asn-128, Glu-129 and Phe-130 in loop A of the 5-HT₃receptor

2006 • 33 citations

Gating properties of mutant acetylcholine receptors.

1994 • 22 citations

The Loop C Region of the Murine 5-HT_3A Receptor Contributes to the Differential Actions of 5-Hydroxytryptamine and m-Chlorophenylbiguanide

2005 • 20 citations

Antiemetics of the 5-Hydroxytryptamine 3A Antagonist Class Inhibit Muscle Nicotinic Acetylcholine Receptors

2005 • 17 citations

1-Oxo-5-hydroxytryptamine: A Surprisingly Potent Agonist of the 5-HT₃ (Serotonin) Receptor

2007 • 13 citations