Determination of optimal vitamin C requirements in humans

Beyond Cholesterol

1989 • 6,533 citations

Vitamin E Consumption and the Risk of Coronary Heart Disease in Men

1993 • 2,363 citations

Clinical pharmacokinetics; concepts and applications

1989 • 2,266 citations

Ascorbate is an outstanding antioxidant in human blood plasma.

1989 • 1,876 citations

Nutrition Intervention Trials in Linxian, China: Supplementation With Specific Vitamin/Mineral Combinations, Cancer Incidence, and Disease-Specific Mortality in the General Population

1993 • 1,783 citations

Paleolithic Nutrition

1985 • 1,310 citations

Free Radicals and Antioxidants: A Personal View

2009 • 1,095 citations

Risk of angina pectoris and plasma concentrations of vitamins A, C, and E and carotene

1991 • 788 citations

Ascorbic acid protects against endogenous oxidative DNA damage in human sperm.

1991 • 784 citations

A Clinical Trial of Antioxidant Vitamins to Prevent Colorectal Adenoma

1994 • 769 citations

New Concepts in the Biology and Biochemistry of Ascorbic Acid

1986 • 650 citations

The Lens Opacities Case-Control Study

1991 • 594 citations

Vitamin C Intake and Mortality among a Sample of the United States Population

1992 • 563 citations

The Biochemical Functions of Ascorbic Acid

1986 • 540 citations

Interaction among vitamin C, vitamin E, and beta-carotene

1995 • 460 citations

3,4-Dihydroxyphenylethylamine β-Hydroxylase

1965 • 451 citations

The Enzymatic Conversion of 3,4-Dihydroxyphenylethylamine to Norepinephrine

1960 • 435 citations

Clinical manifestations of ascorbic acid deficiency in man

1971 • 391 citations

Nutritional status in a healthy elderly population: vitamin C

1982 • 342 citations

Poor plasma status of carotene and vitamin C is associated with higher mortality from ischemic heart disease and stroke Basel Prospective Study

1993 • 328 citations

Protein hydroxylation: prolyl 4‐hydroxylase, an enzyme with four cosubstrates and a multifunctional subunit

1989 • 318 citations

Nutrient intake and cataract extraction in women: a prospective study.

1992 • 316 citations

Physiologic levels of ascorbate inhibit the oxidative modification of low density lipoprotein

1990 • 297 citations

Ascorbic acid recycling in human neutrophils

1993 • 290 citations

Fruit and vegetables in the American diet: data from the NHANES II survey.

1990 • 276 citations

On the requirements of ascorbic acid in man: steady-state turnover and body pool in smokers

1981 • 268 citations

Ascorbic acid and carnitine biosynthesis

1991 • 265 citations

Ascorbic acid and dehydroascorbic acid analyses in biological samples

1992 • 264 citations

SOME PROPERTIES OF THE ASCORBATE FREE RADICAL^*

1975 • 262 citations

Dietary Micronutrient Intake and Risk of Progression to Acquired Immunodeficiency Syndrome (AIDS) in Human Immunodeficiency Virus Type 1 (HlV-1)-infected Homosexual Men

1993 • 259 citations

Ascorbic acid and dehydroascorbic acid measurements in human plasma and serum

1991 • 259 citations

Vitamin C, the common cold, and iron absorption

1977 • 254 citations

Steady-state turnover and body pool of ascorbic acid in man

1979 • 240 citations

Experimental Scurvy in Man

1969 • 236 citations

The role of ascorbate in the prolyl hydroxylase reaction

1978 • 211 citations

Millimolar concentrations of ascorbic acid in purified human mononuclear leukocytes. Depletion and reaccumulation.

1990 • 194 citations

Ascorbic Acid Transport and Accumulation in Human Neutrophils

1989 • 192 citations

Carnitine biosynthesis. beta-Hydroxylation of trimethyllysine by an alpha-ketoglutarate-dependent mitochondrial dioxygenase.

1978 • 189 citations

Acute haemolysis induced by high dose ascorbic acid in glucose-6-phosphate dehydrogenase deficiency.

1993 • 187 citations

Relations among aging, antioxidant status, and cataract

1995 • 185 citations

ENZYMATIC HYDROXYLATION OF PROLINE IN MICROSOMAL POLYPEPTIDE LEADING TO FORMATION OF COLLAGEN

1965 • 184 citations

Nutrient intake and supplementation in the United States (NHANES II).

1986 • 179 citations

ENZYMATIC HYDROXYLATION OF PROLINE AND LYSINE IN PROTOCOLLAGEN

1967 • 171 citations

Purification and characterization of peptidylglycine alpha-amidating monooxygenase from bovine neurointermediate pituitary.

1986 • 169 citations

False-Negative Stool Occult Blood Tests Caused by Ingestion of Ascorbic Acid (Vitamin C)

1975 • 168 citations

Plasma Antioxidants and Risk of Cortical and Nuclear Cataract

1993 • 161 citations

Nutritional status in persons with and without senile cataract: blood vitamin and mineral levels

1988 • 155 citations

Electron transfer across the chromaffin granule membrane.

1983 • 148 citations

Metabolism of 14C- and 3H-labeled l-ascorbic acid in human scurvy

1971 • 145 citations

Ascorbic Acid-Induced Uricosuria

1976 • 144 citations

The effect of high ascorbic acid supplementation on body iron stores

1984 • 138 citations

The distribution of ascorbic acid between the particulate and non-particulate components of adrenal and liver cells

1954 • 137 citations

The use of vitamin supplements and the risk of cataract among US male physicians.

1994 • 136 citations

Coantioxidants make alpha-tocopherol an efficient antioxidant for low-density lipoprotein

1995 • 136 citations

Biochemical indices of human vitamin C status

1987 • 134 citations

Cofactor Requirements of γ-Butyrobetaine Hydroxylase from Rat Liver

1970 • 133 citations

Ascorbic Acid Overdosing: A Risk Factor for Calcium Oxalate Nephrolithiasis

1992 • 129 citations

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase. Purification, characterization, and expression.

1991 • 128 citations

The Influence of Diet on Urinary Risk Factors for Stones in Healthy Subjects and Idiopathic Renal Calcium Stone Formers

1991 • 128 citations

Safety of High‐level Vitamin C Ingestion

1987 • 123 citations

A possible role for vitamins C and E in cataract prevention

1991 • 121 citations

Ascorbic Acid in Endocrine Systems

1985 • 120 citations

Alternative mRNA splicing generates multiple forms of peptidyl-glycine alpha-amidating monooxygenase in rat atrium.

1989 • 116 citations

Effect of High Dose Vitamin C on Urinary Oxalate Levels

1994 • 109 citations

Is There a Physiological Role of Vitamin C in Iron Absorption?

1987 • 105 citations

Ascorbic Acid Metabolism in Man

1966 • 102 citations

Cellular Ascorbate Depletion in Healthy Men

1992 • 102 citations

Metabolism of Ascorbic-1-14C Acid in Experimental Human Scurvy

1969 • 97 citations

The bioavailability to humans of ascorbic acid from oranges, orange juice and cooked broccoli is similar to that of synthetic ascorbic acid.

1993 • 90 citations

Scurvy and Altered Iron Stores in Thalassemia Major

1981 • 88 citations

Ascorbic Acid Depletion in Patients Undergoing Chronic Hemodialysis

1970 • 88 citations

Demographic and economic factors associated with dietary quality for adults in the 1987-88 Nationwide Food Consumption Survey

1992 • 85 citations

Cytochrome b561 catalyzes transmembrane electron transfer.

1984 • 83 citations

Purification and some properties of human 4-hydroxyphenylpyruvate dioxygenase (I).

1977 • 81 citations

Superoxide-dependent oxidation of extracellular reducing agents by isolated neutrophils.

1988 • 80 citations

Studies on the lysyl hydroxylase reaction. I. Initial velocity kinetics and related aspects

1980 • 79 citations

Enhancement of norepinephrine biosynthesis by ascorbic acid in cultured bovine chromaffin cells.

1985 • 74 citations

Ascorbic acid intake and plasma levels in healthy elderly people

1987 • 73 citations

Tissue fractionation and catecholamines

1968 • 72 citations

5-A-DAY: dietary behavior and the fruit and vegetable intake of Latino children.

1994 • 72 citations

Carnitine biosynthesis from gamma-butyrobetaine and from exogenous protein-bound 6-N-trimethyl-L-lysine by the perfused guinea pig liver. Effect of ascorbate deficiency on the in situ activity of gamma-butyrobetaine hydroxylase.

1984 • 71 citations

Ascorbic acid accumulation and transport in human fibroblasts

1993 • 70 citations

Ascorbic acid specifically enhances dopamine beta-monooxygenase activity in resting and stimulated chromaffin cells.

1986 • 69 citations

The relationship between vitamin C intake, general health practices, and mortality in Alameda County, California.

1986 • 66 citations

Ascorbic Acid Aggravates Secondary Hyperoxalemia in Patients on Chronic Hemodialysis

1984 • 66 citations

Inhibition of ascorbic acid transport in human neutrophils by glucose.

1992 • 66 citations

Ascorbic acid regulation of norepinephrine biosynthesis in isolated chromaffin granules from bovine adrenal medulla.

1985 • 65 citations

Ascorbic acid absorption in man — pharmacokinetic implications

1972 • 64 citations

Functional coupling between enzymes of the chromaffin granule membrane.

1986 • 63 citations

THE MECHANISM OF THE EXCRETION OF VITAMIN C BY THE HUMAN KIDNEY AT LOW AND NORMAL PLASMA LEVELS OF ASCORBIC ACID 1

1940 • 63 citations

Effect of large oral doses of ascorbic acid on uric acid excretion by normal subjects

1981 • 59 citations

Separation of prolyl 3-hydroxylase and 4-hydroxylase activities and the 4-hydroxyproline requirement for synthesis of 3-hydroxyproline

1977 • 56 citations

THE ROLE OF ASCORBIC ACID IN TYROSINE METABOLISM

1961 • 55 citations

Dose-dependent absorption and excretion of vitamin C in humans

1986 • 54 citations

A possible etiological role for ascorbate in calculi formation.

1986 • 54 citations

Ascorbic acid and iron metabolism: alterations in lysosomal function

1991 • 53 citations

Effects of different levels of vitamin C intake on the vitamin C concentration in human milk and the vitamin C intakes of breast-fed infants

1985 • 53 citations

Characterization of a peptide alpha-amidation activity in human plasma and tissues

1985 • 53 citations

Electron transfer across the chromaffin granule membrane. Use of EPR to demonstrate reduction of intravesicular ascorbate radical by the extravesicular mitochondrial NADH:ascorbate radical oxidoreductase.

1986 • 51 citations

Evidence for a localization of dopamine‐β‐hydroxylase within the chromaffin granules

1975 • 51 citations

Cytochrome b561, ascorbic acid, and transmembrane electron transfer

1991 • 48 citations

Ascorbic acid within chromaffin granules

1989 • 48 citations

Ascorbic Acid Transport and Distribution in Human B Lymphocytes

1995 • 47 citations

Ascorbic acid and in situ kinetics: a new approach to vitamin requirements

1991 • 46 citations

Principles of Biochemistry

1993 • 45 citations

The role of ascorbate in the biosynthesis of neuroendocrine peptides

1991 • 42 citations

Effect of large doses of ascorbic acid in man on some nitrogenous components of urine.

1983 • 41 citations

Rapid enzymatic determination of urinary oxalate.

1989 • 39 citations

Ascorbic Acid Absorption in Humans: A Comparison among Several Dosage Forms

1982 • 33 citations

Pharmacokinetics of ascorbic acid in man

1976 • 32 citations

Ascorbic Acid: The Concept of Optimum Requirements^a

1987 • 29 citations

Ascorbic acid regeneration in chromaffin granules. In situ kinetics.

1991 • 28 citations

What’s new about scurvy?

1971 • 28 citations

In situ Kinetics and Ascorbic Acid Requirements

2015 • 26 citations

Comparison of the nutritional status of pregnant adolescents with adult pregnant women. I. Biochemical findings

1975 • 25 citations

The Availability of Ascorbic Acid in Papayas and Guavas

1945 • 21 citations

Semidehydroascorbic acid as an intermediate in norepinephrine biosynthesis in chromaffin granules

1991 • 20 citations

A Model to Increase Consumption of Fruit and Vegetables by Implementing the “5‐A‐Day” Initiative

1994 • 14 citations

Point of view defining a nutritious diet: need for new dietary standards.

1992 • 13 citations

Coulometric Electrochemical Detection of Hydroxyproline Using 7-Chloro-4-nitrobenzo-2-oxa-1,3-diazole

1993 • 12 citations

Nutrition Standards for Today

1993 • 7 citations

Cellular functions of ascorbic acid: a means to determine vitamin C requirements.

1993 • 6 citations

Effect of vitamin C supplementation on black mineworkers.

1975 • 5 citations