Binding of the Hepatitis C Virus E2 Glycoprotein to CD81 Is Strain Specific and Is Modulated by a Complex Interplay between Hypervariable Regions 1 and 2

The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets

2014 • 4,782 citations

Interferon Alfa-2b Alone or in Combination with Ribavirin as Initial Treatment for Chronic Hepatitis C

1998 • 3,550 citations

Binding of Hepatitis C Virus to CD81

1998 • 2,042 citations

The envelope glycoprotein from tick-borne encephalitis virus at 2 Å resolution

1995 • 1,417 citations

The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus

2002 • 1,152 citations

Epidemiology of Hepatitis C: Geographic Differences and Temporal Trends

2000 • 1,003 citations

Treatment of Acute Hepatitis C with Interferon Alfa-2b

2001 • 818 citations

Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: potential role in chronic HCV infections.

1992 • 712 citations

Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein

1996 • 607 citations

Vaccination of chimpanzees against infection by thehepatitis C virus.

1994 • 572 citations

CD81 (TAPA-1): A MOLECULE INVOLVED IN SIGNAL TRANSDUCTION AND CELL ADHESION IN THE IMMUNE SYSTEM

1998 • 507 citations

The Fusion Glycoprotein Shell of Semliki Forest Virus

2001 • 504 citations

Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization.

1994 • 496 citations

Characterization of Hepatitis C Virus E2 Glycoprotein Interaction with a Putative Cellular Receptor, CD81

1999 • 470 citations

Inhibition of Natural Killer Cells through Engagement of CD81 by the Major Hepatitis C Virus Envelope Protein

2001 • 458 citations

Binding of the Hepatitis C Virus Envelope Protein E2 to CD81 Inhibits Natural Killer Cell Functions

2001 • 439 citations

Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutant viruses

1994 • 411 citations

Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp70) of hepatitis C virus

1993 • 374 citations

A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells.

1996 • 347 citations

Formation of native hepatitis C virus glycoprotein complexes

1997 • 322 citations

CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs

2001 • 270 citations

Identification of Amino Acid Residues in CD81 Critical for Interaction with Hepatitis C Virus Envelope Glycoprotein E2

2000 • 226 citations

A model for the hepatitis C virus envelope glycoprotein E2

2000 • 209 citations

Therapy of Hepatitis C

1995 • 189 citations

Human Monoclonal Antibodies That Inhibit Binding of Hepatitis C Virus E2 Protein to CD81 and Recognize Conserved Conformational Epitopes

2000 • 188 citations

Functional analysis of hepatitis C virus E2 glycoproteins and virus-like particles reveals structural dissimilarities between different forms of E2

2001 • 186 citations

Characterization of truncated forms of hepatitis C virus glycoproteins.

1997 • 185 citations

Conservation of the Conformation and Positive Charges of Hepatitis C Virus E2 Envelope Glycoprotein Hypervariable Region 1 Points to a Role in Cell Attachment

2001 • 181 citations

Protection against Papillomavirus with a Polynucleotide Vaccine

1996 • 179 citations

Binding of the hepatitis C virus envelope protein E2 to CD81 provides a co-stimulatory signal for human T cells

2001 • 155 citations

Towards a solution for hepatitis C virus hypervariability: mimotopes of the hypervariable region 1can induce antibodies cross-reacting with a large number of viral variants

1998 • 152 citations

Sequence evolution of the hypervariable region in the putative envelope region E2/NS1 of hepatitis C virus is correlated with specific humoral immune responses

1995 • 142 citations

High titers of antibodies inhibiting the binding of envelope to human cells correlate with natural resolution of chronic hepatitis C

1998 • 138 citations

Functional Characterization of Intracellular and Secreted Forms of a Truncated Hepatitis C Virus E2 Glycoprotein

2000 • 115 citations

Binding of Hepatitis C Virus E2 Glycoprotein to CD81 Does Not Correlate with Species Permissiveness to Infection

2000 • 101 citations

Recombinant human monoclonal antibodies against different conformational epitopes of the E2 envelope glycoprotein of hepatitis C virus that inhibit its interaction with CD81

2000 • 86 citations

Construction and characterization of chimeric hepatitis C virus E2 glycoproteins: analysis of regions critical for glycoprotein aggregation and CD81 binding

2000 • 82 citations

Influence of Antibodies to the Hypervariable Region of E2/NS1 Glycoprotein on the Selective Replication of Hepatitis C Virus in Chimpanzees

1994 • 69 citations

Full-length complementary DNA of hepatitis C virus genome from an infectious blood sample

1998 • 62 citations

[Therapy of hepatitis].

1953 • 46 citations

Nonneutralizing Human Antibody Fragments against Hepatitis C Virus E2 Glycoprotein Modulate Neutralization of Binding Activity of Human Recombinant Fabs

2001 • 43 citations

Mimotopes of the hepatitis C virus hypervariable region 1, but not the natural sequences, induce cross-reactive antibody response by genetic immunization

2001 • 40 citations

Expression of Noncovalent Hepatitis C Virus Envelope E1-E2 Complexes Is Not Required for the Induction of Antibodies with Neutralizing Properties following DNA Immunization

1999 • 36 citations

Comparative analysis of amino acid sequences from envelope proteins isolated from different hepatitis C virus variants: possible role of conservative and variable regions

2000 • 29 citations

Management of hepatitis C: A national survey of gastroenterologists and hepatologists

1997 • 28 citations

Production and Characterization of Monoclonal Antibodies Specific for a Conserved Epitope within Hepatitis C Virus Hypervariable Region 1

2001 • 23 citations

In vitro models for hepatitis C

2001 • 12 citations