Nicotinamide is a potent inducer of endocrine differentiation in cultured human fetal pancreatic cells.

THE UNLABELED ANTIBODY ENZYME METHOD OF IMMUNOHISTOCHEMISTRY PREPARATION AND PROPERTIES OF SOLUBLE ANTIGEN-ANTIBODY COMPLEX (HORSERADISH PEROXIDASE-ANTIHORSERADISH PEROXIDASE) AND ITS USE IN IDENTIFICATION OF SPIROCHETES

1970 • 5,141 citations

Automated Method for Isolation of Human Pancreatic Islets

1988 • 1,282 citations

An improved fluorometric assay for DNA

1971 • 997 citations

ADP-RIBOSYLATION

1985 • 710 citations

Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons

1988 • 455 citations

Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function.

1992 • 309 citations

A SIMPLE METHOD OF STAINING FRESH AND CULTURED ISLETS

1988 • 261 citations

Preventive and Therapeutic Effects of Large-Dose Nicotinamide Injections on Diabetes Associated with Insulitis: An Observation in Nonobese Diabetic (NOD) Mice

1982 • 221 citations

Prevention or delay of Type 1 (insulin-dependent) diabetes mellitus in children using nicotinamide

1991 • 176 citations

Method for Large-Scale Isolation of Pancreatic Islets by Tissue Culture of Fetal Rat Pancreas

1979 • 173 citations

Amelioration of Diabetes Mellitus in Partially Depancreatized Rats by Poly(ADP-ribose) Synthetase Inhibitors: Evidence of Islet B-Cell Regeneration

1984 • 161 citations

Interrelationship between poly (ADP-Rib) synthesis, intracellular NAD levels, and muscle or cartilage differentiation from mesodermal cells of embryonic chick limb.

1975 • 158 citations

The midgestational human fetal pancreas contains cells coexpressing islet hormones

1992 • 127 citations

Molecular basis of experimental diabetes: Degeneration, oncogenesis and regeneration of pancreatic B‐cells of islets of Langerhans

1985 • 110 citations

Induction of Islet Cytodifferentiation by Fetal Mesenchyme in Adult Pancreatic Ductal Epithelium

1991 • 93 citations

Transcriptional Regulation of Genes Encoding Insulin, Glucagon, and Angiotensinogen by Sodium Butyrate in a Rat Islet Cell Line

1987 • 83 citations

Mechanisms of Nicotinamide and Thymidine Protection From Alloxan and Streptozocin Toxicity

1988 • 83 citations

Induction of murine teratocarcinoma cell differentiation by suppression of poly(ADP-ribose) synthesis.

1984 • 80 citations

Effect of nicotinamide treatment on the residual insulin secretion in Type 1 (insulin-dependent) diabetic patients

1989 • 80 citations

Maturation of Insulin Response to Glucose During Human Fetal and Neonatal Development: Studies with Perifusion of Pancreatic Isletlike Cell Clusters

1988 • 77 citations

Pretreatment of fetal porcine pancreas in culture with nicotinamide accelerates reversal of diabetes after transplantation to nude mice.

1993 • 76 citations

Effect of nicotinamide therapy upon B-cell function in newly diagnosed Type 1 (insulin-dependent) diabetic patients

1989 • 67 citations

On the mechanism of preadipocyte differentiation. Masking of poly(ADP-ribose) synthetase activity during differentiation of 3T3-L1 preadipocytes.

1981 • 59 citations

Functional Impact of Attachment and Purification in the Short Term Culture of Human Pancreatic Islets*

1991 • 58 citations

Poly(adenosine diphosphate ribose) synthetase activity in nuclei of dividing and of non-dividing but differentiating intestinal epithelial cells

1979 • 55 citations

Transcriptional regulation of genes encoding insulin, glucagon, and angiotensinogen by sodium butyrate in a rat islet cell line.

1987 • 54 citations

Thymic selection defines multiple T cell receptor V beta ‘repertoire phenotypes’ at the CD4/CD8 subset level.

1990 • 43 citations

Double-Blind Randomized Trial of Nicotinamide on Early-Onset Diabetes

1992 • 43 citations

Maturation of the response of human fetal pancreatic expiants to glucose

1985 • 42 citations

Long-term effects of exposure of pancreatic islets to nicotinamide in vitro on DNA synthesis, metabolism and B-cell function

1986 • 42 citations

Tissue Culture of Human Fetal Pancreas; Effects of Nicotinamide on Insulin Production and Formation of Isletlike Cell Clusters

1989 • 41 citations

Immunoalkaline Phosphatase Labeling of Terminal Transferase in Hematologic Samples

1987 • 39 citations

STIMULATION OF CELL REPLICATION IN TRANSPLANTED PANCREATIC ISLETS BY NICOTINAMIDE TREATMENT

1988 • 39 citations

Morphologic Study of Cultured Pancreatic Fetal Islets During Maturation of the Insulin Stimulus-secretion Mechanism

1980 • 38 citations

Effects of Growth Hormone and Insulin-Like Growth Factor I on Endocrine Function of Human Fetal Islet-Like Cell Clusters During Long-Term Tissue Culture

1988 • 36 citations

Induction of islet cytodifferentiation by fetal mesenchyme in adult pancreatic ductal epithelium

1991 • 35 citations

Glucose Affectsin VitroMaturation of Fetal Rat Islets*

1984 • 34 citations

Inhibition of Cytokine-Induced MHC Class II but Not Class I Molecule Expression on Mouse Islet Cells by Niacinamide and 3-Aminobenzamide

1990 • 27 citations

Successful Long-Term Cryopreservation and Transplantation of Human Fetal Pancreas

1989 • 26 citations

Enhanced chondrocytic differentiation in chick limb bud cell cultures by inhibitors of poly(ADP-ribose) synthetase

1983 • 26 citations

Effect of poly(ADP-ribose) synthetase inhibitor administration to rats before and after injection of alloxan and streptozotocin on islet proinsulin synthesis

1983 • 23 citations

Effects of poly (ADP-ribose) synthetase inhibitor on b-cells of a canine pancreas after massive pancreatectomy

1991 • 17 citations

Morphologic study of cultured pancreatic fetal islets during maturation of the insulin stimulus-secretion mechanism

1980 • 15 citations

Characterization of Endocrine-Rich Monolayers of Human Fetal Pancreas That Display Reduced Immunogenicity

1991 • 14 citations

Successful long-term cryopreservation and transplantation of human fetal pancreas

1989 • 14 citations

Lack of glucose-induced functional maturation during long-term culture of human fetal islet cells

1991 • 9 citations

Maturation of insulinogenic response to glucose in human fetal pancreas with retinoic acid.

1990 • 9 citations

Morphology, yield and functional integrity of islet-like cell clusters in tissue culture of human fetal pancreata obtained after different means of abortion

1988 • 8 citations

Maturation of insulinogenic response to glucose in human fetal pancreas with retinoic acid.

1990 • 5 citations

Sensitivity in vitro of mature and immature mouse thymocytes to dexamethasone cytotoxicity and its correlation to poly ADP-ribosylation.

1992 • 5 citations

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