Pathways Mediating Resistance to Vascular Endothelial Growth Factor–Targeted Therapy

Paclitaxel–Carboplatin Alone or with Bevacizumab for Non–Small-Cell Lung Cancer

2006 • 5,595 citations

Sunitinib versus Interferon Alfa in Metastatic Renal-Cell Carcinoma

2007 • 5,572 citations

Sorafenib in Advanced Clear-Cell Renal-Cell Carcinoma

2007 • 4,669 citations

Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis

2004 • 2,891 citations

Bevacizumab in Combination With Oxaliplatin-Based Chemotherapy As First-Line Therapy in Metastatic Colorectal Cancer: A Randomized Phase III Study

2008 • 2,832 citations

Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor

1998 • 2,440 citations

A quantitative analysis of kinase inhibitor selectivity

2008 • 2,334 citations

Bevacizumab in Combination With Oxaliplatin, Fluorouracil, and Leucovorin (FOLFOX4) for Previously Treated Metastatic Colorectal Cancer: Results From the Eastern Cooperative Oncology Group Study E3200

2007 • 2,221 citations

AZD2171, a Pan-VEGF Receptor Tyrosine Kinase Inhibitor, Normalizes Tumor Vasculature and Alleviates Edema in Glioblastoma Patients

2007 • 1,742 citations

VEGF-targeted therapy: mechanisms of anti-tumour activity

2008 • 1,604 citations

Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors

2005 • 1,578 citations

Vascular Permeability Factor/Vascular Endothelial Growth Factor: A Critical Cytokine in Tumor Angiogenesis and a Potential Target for Diagnosis and Therapy

2002 • 1,549 citations

Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

1999 • 1,248 citations

Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation

2004 • 1,176 citations

Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

2006 • 1,020 citations

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

2006 • 970 citations

Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells

2007 • 831 citations

Anti-PlGF Inhibits Growth of VEGF(R)-Inhibitor-Resistant Tumors without Affecting Healthy Vessels

2007 • 765 citations

Molecular mechanisms of lymphangiogenesis in health and disease

2002 • 709 citations

Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?

2002 • 685 citations

VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development

1996 • 684 citations

Bevacizumab Beyond First Progression Is Associated With Prolonged Overall Survival in Metastatic Colorectal Cancer: Results From a Large Observational Cohort Study (BRiTE)

2008 • 677 citations

Bv8 regulates myeloid-cell-dependent tumour angiogenesis

2007 • 614 citations

Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiationRole of oxygenation, angiopoietin-1, and matrix metalloproteinases

2004 • 549 citations

Vascular Endothelial Growth Factor Signaling Pathways: Therapeutic Perspective

2006 • 544 citations

Blocking Neuropilin-1 Function Has an Additive Effect with Anti-VEGF to Inhibit Tumor Growth

2007 • 526 citations

VEGF₁₆₅ mediates formation of complexes containing VEGFR‐2 and neuropilin‐1 that enhance VEGF₁₆₅‐receptor binding

2002 • 456 citations

Functions of Paracrine PDGF Signaling in the Proangiogenic Tumor Stroma Revealed by Pharmacological Targeting

2008 • 424 citations

Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth

2008 • 394 citations

Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy

2007 • 367 citations

Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression

2008 • 299 citations

Neuropilin-1 Binds Vascular Endothelial Growth Factor 165, Placenta Growth Factor-2, and Heparin via Its b1b2 Domain

2002 • 257 citations

The role of neuropilins in cancer

2006 • 247 citations

Vascular Endothelial Growth Factor Receptor 3 Is Involved in Tumor Angiogenesis and Growth

2007 • 237 citations

Induction of VEGF in perivascular cells defines a potential paracrine mechanism for endothelial cell survival

2001 • 221 citations

The Role of Neuropilin in Vascular and Tumor Biology

2002 • 215 citations

Bv8, a small protein from frog skin and its homologue from snake venom induce hyperalgesia in rats

1999 • 186 citations

Tyrosine kinase inhibition of multiple angiogenic growth factor receptors improves survival in mice bearing colon cancer liver metastases by inhibition of endothelial cell survival mechanisms.

2001 • 165 citations

Properties of Two VEGF Receptors, Flt‐1 and KDR, in Signal Transduction^a

2000 • 123 citations

Delta-like 4/Notch Signaling and Its Therapeutic Implications

2007 • 121 citations

Vascular Endothelial Growth Factor Signaling Pathways: Therapeutic Perspective

2008 • 84 citations

Targeting endothelial and tumor cells with semaphorins

2007 • 83 citations