Therapy of acute myeloid leukemia: towards a patient-oriented, risk-adapted approach.

Nonmyeloablative Stem Cell Transplantation and Cell Therapy as an Alternative to Conventional Bone Marrow Transplantation With Lethal Cytoreduction for the Treatment of Malignant and Nonmalignant Hematologic Diseases

1998 • 1,984 citations

AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis

1996 • 1,885 citations

Chromosomal translocations in human cancer

1994 • 1,551 citations

Intensive Postremission Chemotherapy in Adults with Acute Myeloid Leukemia

1994 • 1,428 citations

Oncogenic Transcription Factors in the Human Acute Leukemias

1997 • 1,227 citations

All-trans-Retinoic Acid in Acute Promyelocytic Leukemia

1997 • 1,090 citations

TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis.

1995 • 566 citations

Molecular Remission in PML/RARα-Positive Acute Promyelocytic Leukemia by Combined All-trans Retinoic Acid and Idarubicin (AIDA) Therapy

1997 • 492 citations

A randomized study of high-dose cytarabine in induction in acute myeloid leukemia [see comments]

1996 • 474 citations

A randomized investigation of high-dose versus standard-dose cytosine arabinoside with daunorubicin in patients with previously untreated acute myeloid leukemia: a Southwest Oncology Group study

1996 • 423 citations

Results of a randomized trial comparing idarubicin and cytosine arabinoside with daunorubicin and cytosine arabinoside in adult patients with newly diagnosed acute myelogenous leukemia

1991 • 377 citations

AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia

1995 • 346 citations

Timed-sequential induction therapy improves postremission outcome in acute myeloid leukemia: a report from the Children's Cancer Group

1996 • 340 citations

Early Detection of Relapse by Prospective Reverse Transcriptase-Polymerase Chain Reaction Analysis of the PML/RARα Fusion Gene in Patients With Acute Promyelocytic Leukemia Enrolled in the GIMEMA-AIEOP Multicenter “AIDA” Trial

1998 • 317 citations

Comparison of three remission induction regimens and two postinduction strategies for the treatment of acute nonlymphocytic leukemia: a cancer and leukemia group B study

1987 • 305 citations

Prognostic impact of cytogenetic abnormalities in patients with de novo acute nonlymphocytic leukemia

1989 • 294 citations

Etoposide in acute nonlymphocytic leukemia. Australian Leukemia Study Group

1990 • 276 citations

Immunophenotyping Investigation of Minimal Residual Disease Is a Useful Approach for Predicting Relapse in Acute Myeloid Leukemia Patients

1997 • 271 citations

8;21 translocation in acute granulocytic leukaemia: cytological, cytochemical and clinical features

1984 • 248 citations

Expression of the Neural Cell Adhesion Molecule CD56 Is Associated With Short Remission Duration and Survival in Acute Myeloid Leukemia With t(8; 21)(q22; q22)

1997 • 234 citations

Cytogenetic pattern in acute myelogenous leukemia: a major reproducible determinant of outcome.

1988 • 222 citations

Molecular pathogenesis of the chromosome 16 inversion in the M4Eo subtype of acute myeloid leukemia [see comments]

1995 • 220 citations

Acute myelomonocytic leukemia with abnormal eosinophils and inv(16) or t(16;16) has a favorable prognosis

1986 • 211 citations

Molecular basis of IIq23 rearrangements in hematopoietic malignant proliferations

1995 • 211 citations

The Molecular Basis of Leukemia

1994 • 210 citations

High-dose cytosine arabinoside and mitoxantrone: a highly effective regimen in refractory acute myeloid leukemia

1987 • 201 citations

Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers.

1992 • 194 citations

Autologous Bone Marrow Transplantation for Acute Promyelocytic Leukemia in Second Remission: Prognostic Relevance of Pretransplant Minimal Residual Disease Assessment by Reverse-Transcription Polymerase Chain Reaction of the PML/RARα Fusion Gene

1997 • 187 citations

Fludarabine and Arabinosylcytosine Therapy of Refractory and Relapsed Acute Myelogenous Leukemia

1993 • 159 citations

Immunocytochemical Diagnosis of Acute Promyelocytic Leukemia (M3) With the Monoclonal Antibody PG-M3 (Anti-PML)

1997 • 141 citations

Chemotherapy v marrow transplantation for adults with acute nonlymphocytic leukemia: a five-year follow-up

1988 • 137 citations

FLAG (fludarabine + high-dose cytarabine + G-CSF): an effective and tolerable protocol for the treatment of 'poor risk' acute myeloid leukemias.

1994 • 132 citations

Acute myeloid leukemia M4 with bone marrow eosinophilia (M4Eo) and inv(16)(p13q22) exhibits a specific immunophenotype with CD2 expression

1993 • 128 citations

Comparison of allogeneic or autologous bone marrow transplantation and chemotherapy in patients with acute myeloid leukaemia in first remission: a prospective controlled trial

1989 • 127 citations

Clinical and prognostic significance of chromosomal abnormalities in childhood acute myeloid leukemia de novo.

1995 • 121 citations

Fluorescence in situ hybridization: a sensitive method for trisomy 8 detection in bone marrow specimens.

1992 • 117 citations

Correlation of cytogenetic findings with clinical features in 18 patients with inv(3)(q21q26) or t(3;3)(q21;q26).

1994 • 106 citations

Prognostic significance of chromosomal abnormalities in acute nonlymphocytic leukemia: A study of 343 patients

1987 • 98 citations

Detection of monosomy 7 and trisomy 8 in myeloid neoplasia: a comparison of banding and fluorescence in situ hybridization

1993 • 84 citations

Mitoxantrone, etoposide and intermediate-dose Ara-C (MEC): an effective regimen for poor risk acute myeloid leukemia.

1993 • 57 citations

Autologous bone marrow transplantation following high dose chemotherapy for the treatment of adult patients with acute myeloid leukaemia

1986 • 57 citations

ALL-1 gene rearrangements in acute myeloid leukemia: association with M4-M5 French-American-British classification subtypes and young age.

1995 • 53 citations

PML/RAR‐α rearrangement in acute promyelocytic leukaemias apparently lacking the t(15;17) translocation

1992 • 50 citations

Longterm effects of prolonged maintenance and of very early intensification chemotherapy in AML: data from AMLCG.

1992 • 49 citations

The PML/RAR alpha fusion gene in the diagnosis and monitoring of acute promyelocytic leukemia.

1995 • 42 citations

Detection and monitoring of trisomy 8 by fluorescence in situ hybridization in acute myeloid leukemia: a multicentric study.

1998 • 34 citations

The role of all-trans-retinoic acid (ATRA) treatment in newly-diagnosed acute promyelocytic leukemia patients aged >60 years

1997 • 27 citations

Cures of leukemia with aggressive postremission treatment: an update of timed sequential therapy (Ac-D-Ac).

1989 • 24 citations

Peripheral blood stem cells in acute myeloid leukemia: biology and clinical applications.

1996 • 23 citations

[Acute myeloblastic leukemia in children].

1977 • 9 citations

Therapy decisions in leukemia.

1992 • 6 citations