Role of cytokines in the regulation of bone resorption

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

1990 • 1,763 citations

Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6

1992 • 1,437 citations

Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors

1986 • 1,433 citations

IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release.

1990 • 493 citations

Actions of recombinant interleukin 1, interleukin 2, and interferon-gamma on bone resorption in vitro.

1986 • 484 citations

Interleukin-1 and tumor necrosis factor stimulate the formation of human osteoclastlike cells in vitro

1989 • 467 citations

Recombinant human stem cell factor synergises with GM-CSF, G-CSF, IL-3 and epo to stimulate human progenitor cells of the myeloid and erythroid lineages.

1991 • 454 citations

Successful Bone-Marrow Transplantation for Infantile Malignant Osteopetrosis

1980 • 449 citations

Production of Lymphotoxin, a Bone-Resorbing Cytokine, by Cultured Human Myeloma Cells

1987 • 386 citations

Alpha and beta human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria.

1985 • 382 citations

Ovarian steroid treatment blocks a postmenopausal increase in blood monocyte interleukin 1 release.

1989 • 381 citations

Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells: A possible role of interleukin-6 in osteoclastogenesis

1989 • 376 citations

Interleukin 6. A potential autocrine/paracrine factor in Paget's disease of bone.

1992 • 363 citations

Congenital osteoclast deficiency in osteopetrotic (op/op) mice is cured by injections of macrophage colony-stimulating factor.

1991 • 359 citations

Bone Resorption Restored in Osteopetrotic Mice by Transplants of Normal Bone Marrow and Spleen Cells

1975 • 343 citations

In vitro formation of osteoclasts from long-term cultures of bone marrow mononuclear phagocytes.

1982 • 333 citations

Transforming growth factor beta inhibits formation of osteoclast-like cells in long-term human marrow cultures.

1988 • 297 citations

Essential role of macrophage colony-stimulating factor in the osteoclast differentiation supported by stromal cells.

1991 • 284 citations

Kinetic and cytochemical identification of osteoclast precursors and their differentiation into multinucleated osteoclasts.

1986 • 265 citations

Transforming growth factor beta inhibits bone resorption in fetal rat long bone cultures.

1988 • 262 citations

Control of bone resorption by hematopoietic tissue. The induction and reversal of congenital osteopetrosis in mice through use of bone marrow and splenic transplants.

1975 • 248 citations

Infusions of recombinant human interleukins 1 alpha and 1 beta cause hypercalcemia in normal mice.

1988 • 218 citations

Chinese Hamster Ovarian Cells Transfected with the Murine lnterleukin-6 Gene cause Hypercalcemia as well as Cachexia, Leukocytosis and Thrombocytosis in Tumor-Bearing Nude Mice

1991 • 207 citations

Recombinant human interferon-gamma inhibits formation of human osteoclast-like cells.

1986 • 187 citations

Role of colony-stimulating factors in osteoclast development

1991 • 176 citations

The Modulation of the Expression of IL-6 and Its Receptor in Human Osteoblastsin Vitro*

1991 • 159 citations

Evidence for an autocrine/paracrine role for interleukin-6 in bone resorption by giant cells from giant cell tumors of bone.

1992 • 156 citations

Tumors Producing Human Tumor Necrosis Factor Induce Hypercalcemia and Osteoclastic Bone Resorption in Nude Mice*

1989 • 154 citations

Stimulation of Bone Resorption in Vitro by Synthetic Transforming Growth Factor-Alpha

1985 • 154 citations

Origin of Osteoclasts from the Fusion of Phagocytes

1963 • 141 citations

Recombinant human transforming growth factor-alpha stimulates the formation of osteoclast-like cells in long-term human marrow cultures.

1986 • 120 citations

Identification of osteoclast-specific monoclonal antibodies.

1985 • 112 citations

Interleukin-4 as a potent inhibitor of bone resorption

1990 • 110 citations

The Effect of Hemopoietic Growth Factors on the Generation of Osteoclast-Like Cells in Mouse Bone Marrow Cultures

1990 • 106 citations

Marrow transplantation for juvenile osteopetrosis

1981 • 98 citations

On the histogenesis of the cells in fracture callus. Electron microscopic autoradiographic observations in parabiotic rats and studies on labeled monocytes.

1973 • 96 citations

Interleukin 4 inhibits murine osteoclast formation in vitro

1991 • 86 citations

Stimulation of bone resorption in vitro by a non-prostanoid factor released by human monocytes in culture

1983 • 86 citations

On the histogenesis of the cells in fracture callus

1972 • 74 citations

Effects of stem cell factor on osteoclast-like cell formation in long-term human marrow cultures

1992 • 38 citations

Expression of human transforming growth factor α by chinese hamster ovarian tumors in nude mice causes hypercalcemia and increased osteoclastic bone resorption

1992 • 27 citations