Effect of tauroursodeoxycholic acid on bile-acid-induced apoptosis and cytolysis in rat hepatocytes

Chapter 4 Preparation of Isolated Rat Liver Cells

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Dose‐dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli

1991 • 816 citations

A Multicenter, Controlled Trial of Ursodiol for the Treatment of Primary Biliary Cirrhosis

1991 • 727 citations

Quantitative estimation of the hydrophilic-hydrophobic balance of mixed bile salt solutions.

1989 • 523 citations

Ursodeoxycholic acid in the treatment of primary biliary cirrhosis

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Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: A placebo-controlled trial

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The canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis

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Ursodeoxycholic acid in primary biliary cirrhosis: Results of a controlled double-blind trial

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A randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid in primary biliary cirrhosis*1

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Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes.

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Mechanism of Cholestasis

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Apoptosis and hepatobiliary disease

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Ursodeoxycholate reduces hepatotoxicity of bile salts in primary human hepatocytes

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Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection.

1995 • 231 citations

Effect of ursodeoxycholic acid on liver and bile duct disease in primary sclerosing cholangitis. A 3-year pilot study with a placebo-controlled study period

1994 • 225 citations

Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts:In vitro studies in rat hepatocytes and human erythrocytes

1991 • 208 citations

Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes

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Effects of bile salts on the plasma membranes of isolated rat hepatocytes

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A randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid in primary biliary cirrhosis

1995 • 113 citations

Ursodeoxycholate conjugates protect against disruption of cholesterol-rich membranes by bile salts

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Nuclear serine protease activity contributes to bile acid-induced apoptosis in hepatocytes

1995 • 90 citations

Apoptosis and hepatobiliary disease*1

1995 • 83 citations

Ursodeoxycholate protects oxidative mitochondrial metabolism from bile acid toxicity: Dose-response study in isolated rat liver mitochondria

1994 • 77 citations

Tauroursodeoxycholate and tauro-beta-muricholate exert cytoprotection by reducing intrahepatocyte taurochenodeoxycholate content.

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Effects of ursodeoxycholic acid and chenodeoxycholic acid on human hepatocytes in primary culture

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Bile acids in liver diseases

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Effects of ursodeoxycholic acid and chenodeoxycholic acid on human hepatocytes in primary culture

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