Uncoupling of Rat Cerebral Cortical α₂‐Adrenoceptors from GTP‐Binding Proteins by N‐Ethylmaleimide

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii

2007 • 11,720 citations

G proteins and dual control of adenylate cyclase

1984 • 1,811 citations

A graphic method for the determination and presentation of binding parameters in a complex system

1967 • 1,524 citations

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

1984 • 1,300 citations

Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase.

1984 • 585 citations

Islet-activating protein, pertussis toxin: a probe for functions of the inhibitory guanine nucleotide regulatory component of adenylate cyclase

1984 • 567 citations

Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via alpha-adrenergic, cholinergic, and opiate receptors in neuroblastoma x glioma hybrid cells.

1983 • 493 citations

Ras -Transformed Cells: Altered Levels of Phosphatidylinositol-4,5-Bisphosphate and Catabolites

1986 • 450 citations

Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production

1986 • 406 citations

Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain.

1986 • 341 citations

Activation and attenuation of adenylate cyclase. The role of GTP-binding proteins as macromolecular messengers in receptor–cyclase coupling

1981 • 322 citations

Two guanine nucleotide-binding proteins in rat brain serving as the specific substrate of islet-activating protein, pertussis toxin. Interaction of the alpha-subunits with beta gamma-subunits in development of their biological activities.

1986 • 315 citations

The ras oncogene product p21 is not a regulatory component of adenylate cyclase

1985 • 210 citations

Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles.

1986 • 199 citations

ADP-ribosylation of adenylate cyclase by pertussis toxin. Effects on inhibitory agonist binding.

1984 • 189 citations

Uncoupling of alpha-adrenoceptor-mediated inhibition of human platelet adenylate cyclase by N-ethylmaleimide.

1982 • 158 citations

Reconstitution of the muscarinic acetylcholine receptor. Guanine nucleotide-sensitive high affinity binding of agonists to purified muscarinic receptors reconstituted with GTP-binding proteins (Gi and Go).

1986 • 150 citations

Prevention of the agonist binding to gamma-aminobutyric acid B receptors by guanine nucleotides and islet-activating protein, pertussis toxin, in bovine cerebral cortex. Possible coupling of the toxin-sensitive GTP-binding proteins to receptors.

1985 • 148 citations

Multiple α₂‐Noradrenergic Receptor Sites in Rat Brain: Selective Regulation of High‐Affinity [³H] Clonidine Binding by Guanine Nucleotides and Divalent Cations

1980 • 125 citations

Uncoupling of gamma-aminobutyric acid B receptors from GTP-binding proteins by N-ethylmaleimide: effect of N-ethylmaleimide on purified GTP-binding proteins.

1986 • 101 citations

Altered activity of the inhibitory guanyl nucleotide-binding component (Ni) induced by pertussis toxin. Uncoupling of Ni from receptor with continued coupling of Ni to the catalytic unit.

1984 • 100 citations

Purification and characterization of the human platelet alpha 2-adrenergic receptor.

1986 • 94 citations

Two different modifications of the neuroblastoma X glioma hybrid opiate receptors induced by N-ethylmaleimide.

1981 • 63 citations

Selective decrease in the affinity of D2 dopamine receptor for agonist induced by islet-activating protein, pertussis toxin, associated with ADP-ribosylation of the specific membrane protein of bovine striatum

1983 • 52 citations

Quantitative analysis of rat brain α2-receptors discriminated by [3H]clonidine and [3H]rauwolscine

1984 • 43 citations

Decrease of Clonidine Binding Affinity to α₂‐Adrenoceptor by ADP‐Ribosylation of 41,000‐Dalton Proteins in Rat Cerebral Cortical Membranes by Islet‐Activating Protein

1985 • 40 citations

Dopamine receptor of the porcine anterior pituitary gland. Effects of N-ethylmaleimide and heat on ligand binding mimic the effects of guanine nucleotides.

1982 • 38 citations

Possible Involvement of Inhibitory GTP Binding Regulatory Protein in α₂‐Adrenoceptor‐Mediated Inhibition of Adenylate Cyclase Activity in Cerebral Cortical Membranes of Rats

1985 • 38 citations

Pertussis toxin substrate is a guanosine 5′-[β-thio]diphosphate-, N-ethylmaleimide-, Mg2+- and temperature-sensitive GTP-binding protein

1985 • 32 citations

Developmental Changes of Cerebral Cortical [³H]Clonidine Binding in Rats: Influences of Guanine Nucleotide and Cations

1984 • 32 citations

α2-Adrenergic systems: models for exploring hormonal inhibition of adenylate cyclase

1983 • 27 citations

Direct and indirect effects of sulfhydryl blocking agents on agonist and antagonist binding to central α1- and α2-adrenoceptors

1984 • 22 citations

Effect of pertussis toxin on α₂‐adrenoceptors: decreased formation of the high‐affinity state for agonists

1984 • 19 citations

Muscarinic receptors in porcine caudate nucleus. II. Different effects of N-ethylmaleimide on [3H]cis-methyldioxolane binding to heat-labile (guanyl nucleotide-sensitive) sites and heat-stable (guanyl nucleotide-insensitive) sites.

1983 • 18 citations

Expression of intact Ki-ras p21 protein in Escherichiacoli

1985 • 15 citations

Involvement of sulfhydryl groups in cerebral cortical [3H]clonidine binding in developing rats

1983 • 14 citations

[3H]clonidine and [3H]yohimbine binding to solubilized α2-adrenoceptors from rat cerebral cortex

1986 • 8 citations