Tumour necrosis factor-alpha stimulates invasiveness of T-cell hybridomas and cytotoxic T-cell clones by a pertussis toxin-insensitive mechanism.

Adhesion receptors of the immune system

1990 • 6,585 citations

The Biology of Cachectin/TNF -- A Primary Mediator of the Host Response

1989 • 1,679 citations

Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.

1985 • 1,056 citations

G Proteins: A Family of Signal Transducers

1986 • 975 citations

Leukocyte adhesion to endothelium in inflammation

1990 • 882 citations

Naive and memory T cells show distinct pathways of lymphocyte recirculation.

1990 • 792 citations

Induction of intercellular adhesion molecule 1 on primary and continuous cell lines by pro-inflammatory cytokines. Regulation by pharmacologic agents and neutralizing antibodies.

1988 • 569 citations

Tumor necrosis factor is chemotactic for monocytes and polymorphonuclear leukocytes.

1987 • 533 citations

Effect of interleukin 2, interferon-gamma, and mitogens on the production of tumor necrosis factors alpha and beta.

1985 • 492 citations

Immunoregulatory activity of recombinant human tumor necrosis factor (TNF)-alpha: induction of TNF receptors on human T cells and TNF-alpha-mediated enhancement of T cell responses.

1987 • 490 citations

Tumor necrosis factor/cachectin increases permeability of endothelial cell monolayers by a mechanism involving regulatory G proteins.

1989 • 411 citations

Independent regulation of tumor necrosis factor and lymphotoxin production by human peripheral blood lymphocytes.

1987 • 372 citations

Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin 1 in human fibroblasts: role in the induction of interleukin 6.

1988 • 288 citations

Tumour necrosis factor (cachectin) induces phospholipase A2 activity and synthesis of a phospholipase A2-activating protein in endothelial cells

1988 • 203 citations

Interleukin 1-induced augmentation of experimental metastases from a human melanoma in nude mice.

1990 • 199 citations

Stimulation of endothelial cell binding of lymphocytes by tumor necrosis factor.

1987 • 197 citations

T cells bind to cytokine-activated endothelial cells via a novel, inducible sialoglycoprotein and endothelial leukocyte adhesion molecule-1.

1990 • 196 citations

TNF induces c-fos via a novel pathway requiring conversion of arachidonic acid to a lipoxygenase metabolite.

1991 • 159 citations

Cells secreting tumour necrosis factor show enhanced metastasis in nude mice

1990 • 154 citations

Tumor necrosis factor and CD11/CD18 (beta 2) integrins act synergistically to lower cAMP in human neutrophils.

1990 • 151 citations

Tumor necrosis factor signal transduction: Cell-type-specific activation and translocation of protein kinase C

1989 • 130 citations

Involvement of LFA-1 in lymphoma invasion and metastasis demonstrated with LFA-1-deficient mutants.

1989 • 111 citations

Effect of tumor necrosis factor on GTP binding and GTPase activity in HL-60 and L929 cells.

1988 • 101 citations

Mechanisms of organ selective tumour growth by bloodborne cancer cells

1988 • 88 citations

Protein kinase C inhibitors block the enhanced expression of Intercellular Adhesion Molecule-1 on endothelial cells activated by interleukin-1, lipopolysaccharide and tumor necrosis factor

1990 • 86 citations

Location of genes involved in invasion and metastasis on human chromosome 7.

1987 • 85 citations

Tumor necrosis factor and lymphotoxin gene expression in human tumor cell lines.

1988 • 83 citations

Invasiveness of T-cell hybridomas in vitro and their metastatic potential in vivo.

1985 • 62 citations

Involvement of leukocyte function-associated antigen-1 (LFA-1) in the invasion of hepatocyte cultures by lymphoma and T-cell hybridoma cells.

1987 • 53 citations

Stimulation of lymphocyte migration by endotoxin, tumor necrosis factor, and interferon

1989 • 46 citations

Characterization of the receptor for tumor necrosis factor (TNF) and lymphotoxin (LT) on human T lymphocytes. TNF and LT differ in their receptor binding properties and the induction of MHC class I proteins on a human CD4+ T cell hybridoma.

1990 • 44 citations

Inhibition of lymphoma invasion and liver metastasis formation by pertussis toxin.

1987 • 40 citations

Invasiveness in hepatocyte and fibroblast monolayers and metastatic potential of T-cell hybridomas in mice.

1988 • 40 citations

Development of a monolayer invasion assay for the discrimination and isolation of metastatic lymphoma cells.

1987 • 39 citations

T cells and neutrophils exhibit differential adhesion to cytokine-stimulated endothelial cells.

1990 • 38 citations

In Vivo Neutrophil Emigration in Response to Interleukin-1 and Tumor Necrosis Factor-Alpha

1989 • 36 citations

Re-evaluation of the chemotactic activity of tumour necrosis factor for monocytes.

1990 • 33 citations

Tumor Necrosis Factor-α Is Chemokinetic for Lymphokine-Activated Killer Cells: Regulation by Cyclic Adenosine Monophosphate

1991 • 23 citations

Antigen‐dependent, H‐2‐restricted cytolytic and noncytolytic T cell lines with specificity for minor histocompatibility antigens

1982 • 8 citations