Effects of intrahypothalamic administration of antisense DNA for progesterone receptor mRNA on reproductive behavior and progesterone receptor immunoreactivity in female rat

The rat brain in stereotaxic coordinates

1983 • 28,962 citations

Antisense oligonucleotides: a new therapeutic principle

1990 • 1,616 citations

Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.

1990 • 1,510 citations

Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA

1987 • 419 citations

Progestin Receptors in Rat Brain: Distribution and Properties of Cytoplasmic Progestin-Binding Sites*

1980 • 342 citations

Neural Mechanisms of Female Reproductive Behavior

1985 • 256 citations

Progestin receptor levels in rat hypothalamic and limbic nuclei

1982 • 251 citations

The Temporal Relationship between Estrogen-Inducible Progestin Receptors in the Female Rat Brain and the Time Course of Estrogen Activation of Mating Behavior*

1980 • 229 citations

Ligand-Modulated Regulation of Progesterone Receptor Messenger Ribonucleic Acid and Protein in Human Breast Cancer Cell Lines

1988 • 214 citations

Cloning and sequence analysis of rabbit progesterone-receptor complementary DNA.

1986 • 204 citations

Expression and Estrogen Regulation of Progesterone Receptor mRNA in Neurons of the Mediobasal Hypothalamus: Anin SituHybridization Study

1989 • 203 citations

The relationship between levels of exogenous hormones and the display of lordosis by the female rat

1971 • 194 citations

Regulation of Progesterone Receptor Messenger Ribonucleic Acid and Protein Levels in MCF-7 Cells by Estradiol: Analysis of Estrogen’s Effect on Progesterone Receptor Synthesis and Degradation*

1988 • 192 citations

Estradiol-Induced Progestin Receptor Immunoreactivity Is Found Only in Estrogen Receptor-Immunoreactive Cells in Guinea Pig Brain

1989 • 192 citations

Estrogen-progesterone induction of mating in female rats

1974 • 186 citations

Enduring consequences of neonatal treatment with antisense oligodeoxynucleotides to estrogen receptor messenger ribonucleic acid on sexual differentiation of rat brain.

1993 • 181 citations

RNase H cleavage of RNA hybridized to oligonucleotides containing methylphosphonate, phosphorothioate and phosphodiester bonds

1989 • 169 citations

Specific Progesterone Receptors in the Hypothalamus and Anterior Hypophysis of the Rat*

1977 • 154 citations

The Relevance of Hypothalamic and Hyphophyseal Progestin Receptor Regulation in the Induction and Inhibition of Sexual Behavior in the Female Rat

1979 • 153 citations

Immunocytochemical localization of estrogen-induced progestin receptors in guinea pig brain

1988 • 146 citations

Sex Difference in Estradiol Regulation of Progestin Receptor mRNA in Rat Mediobasal Hypothalamus as Demonstrated by in situ Hybridization

1991 • 136 citations

Increased specificity for antisense oligodeoxynucleotide targeting of RNA cleavage by RNase H using chimeric methylphosphonodiester/phosphodiester structures

1992 • 135 citations

In vivostability and kinetics of absorption and disposition of 3' phosphopropyl amine oligonucleotides

1992 • 122 citations

In vitro toxicology and pharmacokinetics of antisense oligonucleotides.

1991 • 120 citations

Sequence and Expression of a Functional Chicken Progesterone Receptor

1987 • 112 citations

Phosphorothioate oligodeoxynucleotides—anti-sense inhibitors of gene expression?

1991 • 108 citations

Molecular cloning, sequence analyses, and expression of complementary DNA encoding murine progesterone receptor

1991 • 101 citations

Immunocytochemical localization of progesterone receptor in the guinea pig central nervous system

1986 • 100 citations

Medicinal chemistry of antisense oligonucleotides--future opportunities.

1991 • 91 citations

Inhibition of sexual behavior in female guinea pigs by a progestin receptor antagonist

1984 • 90 citations

Antagonism of Female Sexual Behavior with Intracerebral Implants of Antiprogestin RU 38486: Correlation with Binding to Neural Progestin Receptors*

1986 • 86 citations

Oligonucleotides as therapeutic agents

1991 • 81 citations

Estrogen plus Progesterone Increases Progestin Receptor Immunoreactivity in the Brain of Ovariectomized Guinea Pigs

1989 • 73 citations

Organisation of the entire rabbit progesterone receptor mRNA and of the promoter and 5′ flanking region of the gene

1988 • 73 citations

In vitro and in vivo pharmacologic activities of antisense oligonucleotides.

1991 • 73 citations

A rapid method of epitope mapping

1988 • 69 citations

Phosphorothioate oligonucleotides: chemistry, purification, analysis, scale-up and future directions.

1991 • 62 citations

Medicinal chemistry of antisense oligonucleotides--future opportunities.

1991 • 31 citations

Actions of progestins on estrous behavior in female rats

1987 • 22 citations

Chronic estrogen exposure maintains elevated levels of progesterone receptor mRNA in guinea pig hypothalamus

1991 • 21 citations

Arginine Vasopressin Levels after Daily Infusions of Antisense Oligonucleotides into the Supraoptic Nucleus^a

1993 • 12 citations