The role of chemotherapy in brain metastases

Recursive partitioning analysis (RPA) of prognostic factors in three radiation therapy oncology group (RTOG) brain metastases trials

1997 • 2,491 citations

Response criteria for phase II studies of supratentorial malignant glioma.

1990 • 2,401 citations

Prophylactic Cranial Irradiation for Patients with Small-Cell Lung Cancer in Complete Remission

1999 • 1,607 citations

Randomized Phase III Study of Temozolomide Versus Dacarbazine in the Treatment of Patients With Advanced Metastatic Malignant Melanoma

2000 • 1,252 citations

Treatment of single brain metastasis: Radiotherapy alone or combined with neurosurgery

1993 • 1,034 citations

The palliation of brain metastases: Final results of the first two studies by the radiation therapy oncology group

1980 • 968 citations

Identification of prognostic factors in patients with brain metastases: a review of 1292 patients

1999 • 717 citations

A randomized trial to assess the efficacy of surgery in addition to radiotherapy in patients with a single cerebral metastasis

1996 • 680 citations

Validation of the RTOG recursive partitioning analysis (RPA) classification for brain metastases

2000 • 533 citations

Gemcitabine and Cisplatin Versus Mitomycin, Ifosfamide, and Cisplatin in Advanced Non–Small-Cell Lung Cancer: A Randomized Phase III Study of the Italian Lung Cancer Project

1999 • 370 citations

Irinotecan Therapy in Adults With Recurrent or Progressive Malignant Glioma

1999 • 353 citations

The palliation of brain metastases in a favorable patient population: A randomized clinical trial by the radiation therapy oncology group

1981 • 339 citations

Phase II Randomized Trial of Temozolomide and Concurrent Radiotherapy in Patients With Brain Metastases

2002 • 335 citations

Chemotherapy induces regression of brain metastases in breast carcinoma

1986 • 271 citations

Results of a phase III study of early versus delayed whole brain radiotherapy with concurrent cisplatin and vinorelbine combination in inoperable brain metastasis of non-small-cell lung cancer: Groupe Français de Pneumo-Cancérologie (GFPC) Protocol 95-1

2001 • 266 citations

A randomized phase iii protocol for the evaluation of misonidazole combined with radiation in the treatment of patients with brain metastases (RTOG-7916)

1991 • 246 citations

Treatment of Brain Metastases of Small-Cell Lung Cancer: Comparing Teniposide and Teniposide With Whole-Brain Radiotherapy—A Phase III Study of the European Organization for the Research and Treatment of Cancer Lung Cancer Cooperative Group

2000 • 239 citations

Response of brain metastases from breast cancer to systemic chemotherapy

1992 • 235 citations

A phase II trial of temozolomide for patients with recurrent or progressive brain metastases.

2001 • 229 citations

Front-line chemotherapy with cisplatin and etoposide for patients with brain metastases from breast carcinoma, nonsmall cell lung carcinoma, or malignant melanoma

1999 • 214 citations

Neurologic Complications of Cancer.

1996 • 205 citations

Front‐line chemotherapy with cisplatin and etoposide for patients with brain metastases from breast carcinoma, nonsmall cell lung carcinoma, or malignant melanoma

1999 • 193 citations

Results of a randomized comparison of radiotherapy and bromodeoxyuridine with radiotherapy alone for brain metastases: Report of RTOG trial 89-05

1995 • 185 citations

Preirradiation paclitaxel in glioblastoma multiforme: efficacy, pharmacology, and drug interactions. New Approaches to Brain Tumor Therapy Central Nervous System Consortium.

1997 • 181 citations

Phase II study of temozolomide in heavily pretreated cancer patients with brain metastases

2001 • 174 citations

High incidence of central nervous system involvement in patients with metastatic or locally advanced breast cancer treated with epirubicin and docetaxel

2001 • 150 citations

Temozolomide and whole brain irradiation in melanoma metastatic to the brain: a phase II trial of the Cytokine Working Group

2002 • 148 citations

First-Line Chemotherapy with Vinorelbine, Gemcitabine, and Carboplatin in the Treatment of Brain Metastases from Non-Small-Cell Lung Cancer: A Phase II Study

2002 • 139 citations

Multidrug resistance in brain tumors: roles of the blood-brain barrier.

2001 • 133 citations

A critique of the role of the blood-brain barrier in the chemotherapy of human brain tumors

1994 • 133 citations

Response to topotecan of symptomatic brain metastases of small-cell lung cancer also after whole-brain irradiation

2002 • 130 citations

Combination Therapy with Platinum and Etoposide of Brain Metastases from Breast Carcinoma

1990 • 129 citations

Paclitaxel (TAXOL®) concentrations in brain tumor tissue

1994 • 118 citations

Central nervous system progression of metastatic breast cancer in patients treated with paclitaxel

1995 • 112 citations

Effect of temozolomide on central nervous system relapse in patients with advanced melanoma

2002 • 106 citations

The response of cerebral metastases in small cell lung cancer to systemic chemotherapy

1990 • 104 citations

Temozolomide in patients with advanced non-small cell lung cancer with and without brain metastases

2003 • 103 citations

Emergence of increased cerebral metastasis after high-dose preoperative radiotherapy with chemotherapy in patients with locally advanced nonsmall cell lung carcinoma

2001 • 90 citations

Teniposide for brain metastases of small-cell lung cancer: a phase II study. European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group.

1995 • 67 citations

Drug resistance in brain tumors

1994 • 65 citations

Carboplatin as second line treatment for recurrent or progressive brain metastases from small cell lung cancer

1993 • 58 citations

A phase II study of the sequential administration of dacarbazine and fotemustine in the treatment of cerebral metastases from malignant melanoma

1994 • 42 citations

The effect of dexamethasone on the uptake of cisplatin in 9L glioma and the area of brain around tumor.

1998 • 40 citations

Temozolomide in Non—Small-Cell Lung Cancer: Preliminary Results of a Phase II Trial in Previously Treated Patients

2002 • 38 citations

Concomitant brain radiotherapy and vinorelbine–ifosfamide–cisplatin chemotherapy in brain metastases of non-small cell lung cancer

1999 • 34 citations

The diagnosis and management of brain metastases

2001 • 34 citations

Essai de phase III randomisé comparant la fotémustine seule ou associée à une irradiation encéphalique dans les métastases cérébrales de mélanome†

2003 • 33 citations

Factors affecting platinum concentrations in human surgical tumour specimens after cisplatin

1995 • 28 citations

Concomitant brain radiotherapy and high-dose ifosfamide in brain relapses of lung cancer

1997 • 11 citations