The Wellcome Trust Lecture: Mechanisms of molecular trafficking in malaria

Human Malaria Parasites in Continuous Culture

1976 • 7,687 citations

Handbook of experimental pharmacology

1984 • 1,599 citations

Hematology of Infancy and Childhood.

1975 • 918 citations

The Metabolic Basis of Inherited Disease

1983 • 757 citations

Chemotherapy and drug resistance in malaria

1970 • 560 citations

Reversal of Chloroquine Resistance in Plasmodium falciparum by Verapamil

1987 • 558 citations

Biochemistry of Plasmodium (malarial parasites)

1979 • 497 citations

The Metabolic Basis of Inherited Disease.

1991 • 409 citations

Ferriprotoporphyrin IX Fulfills the Criteria for Identification as the Chloroquine Receptor of Malaria Parasites.

1980 • 374 citations

Biochemistry of Plasmodium (malarial parasites).

1979 • 323 citations

Identification of the acidic compartment of Plasmodium falciparum-infected human erythrocytes as the target of the antimalarial drug chloroquine.

1984 • 301 citations

Lipids and the malarial parasite.

1977 • 207 citations

Hematology of Infancy and Childhood

1981 • 206 citations

Formation and properties of aqueous leaks induced in human erythrocytes by electrical breakdown

1985 • 196 citations

New permeability pathways induced in membranes of Plasmodium falciparum infected erythrocytes

1983 • 185 citations

Chemotherapy and drug resistance in malaria

1990 • 184 citations

Characterization of permeation pathways in the plasma membrane of human erythrocytes infected with early stages of Plasmodium falciparum: Association with parasite development

1985 • 175 citations

Plasmodium falciparumin Owl Monkeys: Drug Resistance and Chloroquine Binding Capacity

1970 • 166 citations

Uptake of [3H]chloroquine by drug-sensitive and -resistant strains of the human malaria parasite Plasmodium falciparum

1986 • 136 citations

CHLOROQUINE RESISTANCE IN MALARIA: A DEFICIENCY OF CHLOROQUINE BINDING

1969 • 130 citations

Interaction of chlorpromazine with the human erythrocyte membrane.

1984 • 124 citations

Direct interaction of mepacrine with erythrocyte and platelet membrane phospholipid.

1982 • 124 citations

Folate metabolism in malaria.

1977 • 120 citations

Calcium transport of Plasmodium chabaudi-infected erythrocytes.

1982 • 119 citations

Alterations of red blood cell sodium transport during malarial infection

1969 • 118 citations

Chloroquine: Physiological Basis of Drug Resistance in Plasmodium berghei

1966 • 116 citations

Digestion of the host erythrocyte by malaria parasites is the primary target for quinolinecontaining antimalarials

1986 • 112 citations

A protein on Plasmodium falciparum-infected erythrocytes functions as a transferrin receptor

1986 • 109 citations

Membrane structure and function of malaria parasites and the infected erythrocyte

1985 • 108 citations

Formation of aqueous pores in the human erythrocyte membrane after oxidative cross-linking of spectrin by diamide

1983 • 105 citations

The Biochemistry of Intracellular Parasitism.

1962 • 104 citations

A perspective on antimalarial action: Effects of weak bases on Plasmodium falciparum

1986 • 104 citations

Selective stage-specific changes in the permeability to small hydrophilic solutes of human erythrocytes infected with Plasmodium falciparum

1985 • 100 citations

Identification of the parasite transferrin receptor of Plasmodium falciparum-infected erythrocytes and its acylation via 1,2-diacyl-sn-glycerol.

1986 • 98 citations

Phospholipid Biosynthesis in Synchronous Plasmodium falciparum Cultures1

1982 • 96 citations

The antimalarial drug mefloquine binds to membrane phospholipids

1982 • 95 citations

Biophysical analysis of novel transport pathways induced in red blood cell membranes

1987 • 90 citations

Malaria and the permeability of the host erythrocyte

1974 • 88 citations

Alterations in membrane permeability of malaria-infected human erythrocytes are related to the growth stage of the parasite

1982 • 84 citations

Membrane transport of antineoplastic agents

1986 • 83 citations

The sulphur requirements of the erythrocytic form of Plasmodium knowlesi

1956 • 82 citations

On the mechanism of transfer of cholesterol between human erythrocytes and plasma.

1983 • 81 citations

Leak formation in human erythrocytes by the radical-forming oxidant t-

1986 • 79 citations

Phospholipid Biosynthesis by Plasmodium knowlesi-Infected Erythrocytes: The Incorporation of Phospholipid Precursors and the Identification of Previously Undetected Metabolic Pathways

1982 • 78 citations

The biochemistry of intracellular parasitism

1963 • 75 citations

Kinetics of glucose transport in human erythrocytes.

1983 • 72 citations

A reevaluation of the status of cholesterol in erythrocytes infected by Plasmodium knowlesi and P. falciparum

1984 • 71 citations

On the mode of action of phlorizin as an antimalarial agent in in vitro cultures of plasmodium falciparum

1987 • 70 citations

Alterations in the Surface Membrane of Red Blood Cells During Malaria

1982 • 70 citations

Lipid Modulation of Transport Proteins in Vertebrate Cell Membranes

1987 • 70 citations

A reappraisal of the effects of iron and desferrioxamine on the growth of Plasmodium falciparum‘in vitro’: the unimportance of serum iron

1986 • 69 citations

Adenosine uptake, transport, and metabolism in human erythrocytes

1985 • 69 citations

Transport of amino acids and nucleic acid precursors in malarial parasites.

1977 • 68 citations

Permselectivity changes in malaria (Plasmodium falciparum) infected human red blood cell membranes

1983 • 65 citations

Plasmodium falciparum takes up iron from transferrin

1984 • 61 citations

Mechanisms of sulfadoxine resistance in Plasmodium falciparum

1986 • 61 citations

Inward fluxes of adenosine in erythrocytes and cultured cells measured by a quenched-flow method

1984 • 60 citations

l-Glutamine influx in malaria-infected erythrocytes: a Target for antimalarials?

1986 • 60 citations

Malaria parasites (Plasmodium lophurae) Developing Extracellularly in vitro: Incorporation of Labeled Precursors*

1971 • 59 citations

Action of pyrimethamine and related drugs againstPlasmodium knowlesi in vitro

1971 • 57 citations

The effect of intracellular calcium on the sodium pump of human red cells.

1983 • 57 citations

On the mechanism for the red-cell accumulation of mefloquine, an antimalarial drug

1984 • 49 citations

Effect of a ‘sickling pulse’ on calcium and potassium transport in sickle cell trait red cells

1981 • 49 citations

Enhanced Ca2+ uptake by mouse erythrocytes in malarial (Plasmodium berghei) infection

1983 • 48 citations

Amino acid transport and incorporation in red blood cells of normal and Plasmodium knowlesi-infected rhesus monkeys

1970 • 47 citations

Band 3 protein—cholesterol interactions in erythrocyte membranes

1982 • 46 citations

Antimalarial schizontocides: Ferriprotoporphyrin IX interaction hypothesis

1986 • 46 citations

Kinetic tests of models for sugar transport in human erythrocytes and a comparison of fresh and cold-stored cells

1983 • 45 citations

Detailed purine salvage metabolism in and outside the free malarial parasite

1975 • 42 citations

A new look at nonparasitized red cells of malaria-infected monkeys

1982 • 42 citations

Intraerythrocytic plasmodial calcium metabolism

1981 • 41 citations

The Role of Membrane Sulfhydryls in Passive, Mediated Transport Processes and for the Barrier Function of the Erythrocyte Membrane

1986 • 41 citations

Anion transport inhibitors as suppressors of Plasmodium falciparum growth in in vitro cultures.

1983 • 39 citations

Inhibitors of choline transport into Plasmodium-infected erythrocytes are effective antiplasmodial compounds in vitro

1985 • 39 citations

Selectivity properties of pores induced in host erythrocyte membrane by Plasmodium falciparum. Effect of parasite maturation

1986 • 37 citations

Oxidative stress of human erythrocytes by iodate and periodate Reversible formation of aqueous membrane pores due to SH-group oxidation

1984 • 36 citations

Antimalarial interaction with ferriprotoporphyrin IX monomer and its relationship to activity of the blood schizontocides

1987 • 35 citations

Purine Uptake and Utilization by the Avian Malaria Parasite Plasmodium lophurae*

1972 • 35 citations

Glucose Transport in the Malarial (Plasmodium lophurae) Infected Erythrocyte*

1974 • 35 citations

Purine Base and Nucleoside Uptake in Plasmodium berghei and Host Erythrocytes

1980 • 34 citations

In vitro Studies on the Amino Acid Metabolism of Plasmodium knowlesi and the Antiplasmodial Effect of the Isoleucine Antagonists

1969 • 32 citations

The status of zinc in malaria (Plasmodium falciparum) infected human red blood cells: stage dependent accumulation, compartmentation and effect of dipicolinate

1986 • 32 citations

Uptake of l-tryptophan by erythrocytes infected with malaria parasites (Plasmodium falciparum)

1983 • 30 citations

Kinetics of glucose transport in human erythrocytes: zero-trans efflux and infinite-trans efflux at 0°C

1986 • 30 citations

The accumulation of amino acids by Plasmodium lophurae (Avian malaria)

1967 • 29 citations

Incorporation of 14C-amino acids by malarial plasmodia (Plasmodium lophurae)

1974 • 28 citations

Incorporation of 14C-amino acids by malaria (Plasmodium lophurae). I. Role of ions and amino acids in the medium

1969 • 27 citations

Effect of the Antimalarial Chloroquine on the Phospholipid Metabolism of Avian Malaria and Heart Tissue *,†

1966 • 27 citations

The transport of chloroquine across human erythrocyte membranes is mediated by a simple symmetric carrier

1982 • 26 citations

A kinetic analysis of l-tryptophan transport in human red blood cells

1981 • 26 citations

[Nucleic acid metabolism in experimental malaria. 2. Incorporation of adenosine and hypoxanthine into the nucleic acids of malaria parasites (Plasmodium berghei and Plasmodium vinckei)].

1968 • 24 citations

Red blood cell [14C]cholesterol exchange and plasma cholesterol esterifying activity of normal and sickle cell blood

1982 • 24 citations

Uptake of chloroquine-3-H3 by plasmodium knowlesi in vitro.

1969 • 23 citations

A study of the uptake of chloroquine in malaria-infected erythrocytes

1985 • 23 citations

Incorporation of 14C-labelled fatty acids into lipids of rhesus erythrocytes and Plasmodium knowlesi in vitro

1971 • 22 citations

Incorporation of 14C-labelled non-lipid precursors into lipids of Plasmodium knowlesi in vitro

1971 • 20 citations

Purine metabolism by the avian malarial parasite Plasmodium lophurae

1981 • 17 citations

Plasmodium berghei: In vitro incorporation of purine derivatives into nucleic acids

1971 • 17 citations

Magnetic resonance studies of the pathophysiology of murine malaria

1985 • 16 citations

Transport of fatty acids across the membrane of human erythrocyte ghosts

1985 • 16 citations

Incorporaion of 1c-amino-acids by malaria (plasmodium lophurae)

1971 • 15 citations

Effect of inhibitors on glucose transport in malaria (Plasmodium berghei) infected erythrocytes

1986 • 13 citations

Comparison of tritiated hypoxanthine, adenine and adenosine for purine-salvage incorporation into nucleic acids of the malarial parasite, Plasmodium berghei.

1975 • 12 citations

Plasmodium falciparum: Variations in p-aminobenzoic acid requirements as related to sulfadoxine sensitivity

1983 • 11 citations

Plasmodium berghei: Uptake and distribution of chloroquine in infected mouse erythrocytes

1982 • 10 citations

Hypoxanthine transport in normal and malaria-infected erythrocytes

1981 • 9 citations

The uptake and incorporation of nucleosides into normal erythrocytes and erythrocytes containingPlasmodium berghei

1974 • 8 citations

Effect of exogenous lipids incorporated into the membrane of human erythrocytes on its glucose transport activity.

1986 • 7 citations

Amodiaquin accumulation by mouse erythrocytes infected with Plasmodium berghei.

1975 • 4 citations

The biochemistry of the malaria parasite; in vitro studies on the distribution of quinine between blood cells and their suspending medium.

1946 • 4 citations

New permeability pathways induced in membranes of Plasmodium falciparum infected erythrocytes

1986 • 4 citations

Decrease of transport of some polyols in sickle cells

1984 • 3 citations