Multidrug Resistance Protein 4 Protects Bone Marrow, Thymus, Spleen, and Intestine from Nucleotide Analogue–Induced Damage

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

1998 • 1,058 citations

The neuropathogenesis of AIDS

2005 • 1,058 citations

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1997 • 871 citations

Acyclic nucleoside phosphonates: a key class of antiviral drugs

2005 • 648 citations

The MRP family of drug efflux pumps

2003 • 609 citations

MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs

1999 • 579 citations

The MRP4/ABCC4 Gene Encodes a Novel Apical Organic Anion Transporter in Human Kidney Proximal Tubules

2002 • 498 citations

SAAM II: Simulation, analysis, and modeling software for tracer and pharmacokinetic studies

1998 • 439 citations

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein

1997 • 432 citations

Mrp4 Confers Resistance to Topotecan and Protects the Brain from Chemotherapy

2004 • 407 citations

Transport of Cyclic Nucleotides and Estradiol 17-β-d-Glucuronide by Multidrug Resistance Protein 4

2001 • 389 citations

Expression and immunolocalization of the multidrug resistance proteins, MRP1–MRP6 (ABCC1–ABCC6), in human brain

2004 • 369 citations

Characterization of the Transport of Nucleoside Analog Drugs by the Human Multidrug Resistance Proteins MRP4 and MRP5

2003 • 368 citations

Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure

1999 • 352 citations

The Antiviral Nucleotide Analogs Cidofovir and Adefovir Are Novel Substrates for Human and Rat Renal Organic Anion Transporter 1

1999 • 345 citations

Clinical Pharmacokinetics of the Antiviral Nucleotide Analogues Cidofovir and Adefovir

1999 • 304 citations

Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy

2003 • 303 citations

Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione.

1997 • 241 citations

Increased penetration of paclitaxel into the brain by inhibition of P-Glycoprotein.

2003 • 238 citations

Analysis of the MRP4 Drug Resistance Profile in Transfected NIH3T3 Cells

2000 • 227 citations

Drug-Induced Renal Failure: Update on New Medications and Unique Mechanisms of Nephrotoxicity

2003 • 217 citations

Analysis of the In Vivo Functions of Mrp3

2005 • 168 citations

Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter.

1998 • 145 citations

Identification of 779 genetic variations in eight genes encoding members of the ATP-binding cassette, subfamily C (ABCC/MRP/CFTR)

2002 • 134 citations

Expression of MRP4 Confers Resistance to Ganciclovir and Compromises Bystander Cell Killing

2002 • 119 citations

Pharmacokinetics in mice of the anti-retrovirus agent 9-(2-phosphonylmethoxyethyl)adenine.

1992 • 39 citations

9-(2-Phosphonylmethoxyethyl)adenine induces tumor cell differentiation or cell death by blocking cell cycle progression through the S phase.

1999 • 23 citations

Improved and simplified liquid chromatographic assay for adefovir, a novel antiviral drug, in human plasma using derivatization with chloroacetaldehyde

1999 • 20 citations