Fluorescence energy transfer and membrane potential measurements monitor dynamic properties of cell membranes: A critical review

Methods in Enzymology , Vol

1966 • 26,261 citations

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

The Fluid Mosaic Model of the Structure of Cell Membranes

1972 • 8,835 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Mobility measurement by analysis of fluorescence photobleaching recovery kinetics

1976 • 2,658 citations

Single-Channel Recording

1995 • 2,565 citations

Fluorescence Energy Transfer as a Spectroscopic Ruler

1978 • 2,370 citations

Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system

1974 • 2,058 citations

Biological effects of cyclosporin A: A new antilymphocytic agent

1976 • 1,501 citations

Fluorescence correlation spectroscopy. II. An experimental realization

1974 • 1,496 citations

Fluorescence correlation spectroscopy. I. Conceptual basis and theory

1974 • 1,398 citations

Use of resonance energy transfer to monitor membrane fusion

1981 • 1,274 citations

Redistribution and Pinocytosis of Lymphocyte Surface Immunoglobulin Molecules Induced by Anti-Immunoglobulin Antibody

1971 • 1,093 citations

Surface Modulation in Cell Recognition and Cell Growth

1976 • 1,062 citations

T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes

1982 • 1,026 citations

Molecular biology of the cell

1983 • 1,007 citations

Single channel recording

1984 • 981 citations

Transmembrane control of the receptors on normal and tumor cells

1976 • 951 citations

Mechanism by which cyanine dyes measure membrane potential in red blood cells and phosphatidylcholine vesicles

1974 • 949 citations

Membrane Structure: Some General Principles

1973 • 825 citations

The orientational freedom of molecular probes. The orientation factor in intramolecular energy transfer

1979 • 744 citations

Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis?

1984 • 734 citations

Cyclosporine: A New Immunosuppressive Agent for Organ Transplantation

1984 • 596 citations

Dye Indicators of Membrane Potential

1979 • 566 citations

Trans-membrane control of the receptors on normal and tumor cells II. Surface changes associated with transformation and malignancy

1976 • 543 citations

Rotational and lateral diffusion of membrane proteins

1979 • 458 citations

Surface density determination in membranes by fluorescence energy transfer

1978 • 422 citations

An analytic solution to the Förster energy transfer problem in two dimensions

1979 • 418 citations

A voltage‐gated potassium channel in human T lymphocytes.

1985 • 403 citations

Determination of membrane potentials in human and Amphiuma red blood cells by means of a fluorescent probe

1974 • 395 citations

Receptor-Mediated Endocytosis of Hormones in Cultured Cells

1981 • 388 citations

Membrane and Cytoplasmic Changes in B Lymphocytes Induced by Ligand-Surface Immunoglobulin Interaction

1976 • 383 citations

Applications of fluorescence in the biomedical sciences

1986 • 370 citations

Optical probes of membrane potential

1976 • 354 citations

Changes in neuron structure during action potential propagation and synaptic transmission.

1973 • 339 citations

K channels in T lymphocytes: a patch clamp study using monoclonal antibody adhesion

1984 • 308 citations

ANIONIC SITES OF HUMAN ERYTHROCYTE MEMBRANES

1973 • 307 citations

[17] The use of singlet-singlet energy transfer to study macromolecular assemblies

1978 • 302 citations

Fluorescence correlation spectroscopy. III. Uniform translation and laminar flow

1978 • 298 citations

Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx

1985 • 282 citations

Improved fluorescent probes for the measurement of rapid changes in membrane potential

1982 • 257 citations

Currents carried by monovalent cations through calcium channels in mouse neoplastic B lymphocytes.

1985 • 239 citations

The dimeric nature of the gramicidin A transmembrane channel: Conductance and fluorescence energy transfer studies of hybrid channels

1977 • 237 citations

Directed lipid flow in cell membranes

1976 • 235 citations

Interaction of hemoglobin with red blood cell membranes as shown by a fluorescent chromophore

1977 • 232 citations

Comparative measurements of membrane potentials with microelectrodes and voltage-sensitive dyes

1984 • 205 citations

Flow cytometric measurement of fluorescence resonance energy transfer on cell surfaces. Quantitative evaluation of the transfer efficiency on a cell-by-cell basis

1984 • 203 citations

Calculation on fluorescence resonance energy transfer on surfaces

1980 • 194 citations

Fluorescence energy transfer between Ca²⁺ transport ATPase molecules in artificial membranes

1977 • 185 citations

Lateral motion of membrane proteins and biological function

1983 • 184 citations

Translational diffusion in the plasma membrane of single cells as studied by fluorescence microphotolysis

1981 • 182 citations

B cell activation. VIII. Membrane immunoglobulins transduce signals via activation of phosphatidylinositol hydrolysis.

1984 • 180 citations

Transverse location of the fluorescent probe 1,6-diphenyl-1,3,5-hexatriene in model lipid bilayer membrane systems by resonance excitation energy transfer

1985 • 179 citations

T-cell-mediated association of peptide antigen and major histocompatibility complex protein detected by energy transfer in an evanescent wave-field

1986 • 178 citations

Scanning fluorescence correlation spectroscopy. I. Theory and simulation of aggregation measurements

1986 • 170 citations

Lymphocyte membrane potential and Ca²⁺‐sensitive potassium channels described by oxonol dye fluorescence measurements

1985 • 169 citations

An approach to the mapping of antigens on the cell surface.

1968 • 167 citations

Flow cytometry and sorting

1980 • 164 citations

Membrane potential changes during mitogenic stimulation of mouse spleen lymphocytes

1980 • 159 citations

Real-Time Optical Mapping of Neuronal Activity: From Single Growth Cones to the Intact Mammalian Brain

1985 • 158 citations

Enhanced uptake of calcium by transforming lymphocytes

1972 • 158 citations

Molecular association between transplantation antigens and cell surface antigen in adenovirus-transformed cell line.

1978 • 151 citations

Rotational diffusion of epidermal growth factor complexed to cell surface receptors reflects rapid microaggregation and endocytosis of occupied receptors.

1981 • 146 citations

Estimation of membrane potentials of individual lymphocytes by flow cytometry.

1979 • 144 citations

Transmembrane electrical and pH gradients across human erythrocytes and human peripheral lymphocytes

1979 • 136 citations

[4] Measurement of protein rotational diffusion in membranes by flash photolysis

1978 • 132 citations

Fluorescence energy transfer measurements on cell surfaces: A critical comparison of steady‐state fluorimetric and flow cytometric methods

1984 • 132 citations

Fluorescence energy transfer in two dimensions. A numeric solution for random and nonrandom distributions

1982 • 128 citations

Photochemical cross-linking of cell membranes. A test for natural and random collisional cross-links by millisecond cross-linking

1977 • 119 citations

Measuring and manipulating cytosolic Ca2+ with trapped indicators

1984 • 116 citations

B cell activation. I. Anti-immunoglobulin-induced receptor cross-linking results in a decrease in the plasma membrane potential of murine B lymphocytes.

1983 • 112 citations

Concentration Correlation Spectroscopy: A New Biophysical Probe Based on Occupation Number Fluctuations

1975 • 107 citations

Phosphorescence of protein-bound eosin and erythrosin. A possible probe for measurements of slow rotational mobility

1979 • 106 citations

Rotational diffusion of cell surface components by time-resolved phosphorescence anisotropy.

1979 • 105 citations

Cell surface distribution of lectin receptors determined by resonance energy transfer

1976 • 103 citations

Variation of the Transmembrane Potential Level as a Basic Mechanism of Mitosis Control

1970 • 103 citations

Potassium channels mediate killing by human natural killer cells.

1986 • 101 citations

B cell activation. III. B cell plasma membrane depolarization and hyper-Ia antigen expression induced by receptor immunoglobulin cross-linking are coupled.

1983 • 101 citations

Receptor diffusion on cell surfaces modulated by locally bound concanavalin A.

1977 • 96 citations

Proximity of lectin receptors on the cell surface measured by fluorescence energy transfer in a flow system.

1979 • 96 citations

B cell activation. IV. Induction of cell membrane depolarization and hyper-I-A expression by phorbol diesters suggests a role for protein kinase C in murine B lymphocyte activation.

1984 • 93 citations

Scanning fluorescence correlation spectroscopy. II. Application to virus glycoprotein aggregation

1986 • 91 citations

Anisotropic molecular motion on cell surfaces.

1979 • 91 citations

ROTATIONAL DIFFUSION OF BIOLOGICAL MACROMOLECULES BY TIME‐RESOLVED DELAYED LUMINESCENCE (PHOSPHORESCENCE, FLUORESCENCE) ANISOTROPY

1981 • 90 citations

Energy transfer in lipid bilayers

1979 • 88 citations

Molecular association between major histocompatibility complex class I antigens and insulin receptors in mouse liver membranes.

1985 • 87 citations

Use of nonspecific dye labeling for singlet energy-transfer measurements in complex systems. Simple model

1972 • 80 citations

Analysis of cell surface interactions by measurements of lateral mobility

1979 • 76 citations

Distribution and mobility of murine histocompatibility H-2Kk antigen in the cytoplasmic membrane.

1983 • 73 citations

Molecular mobility on the cell surface.

1981 • 69 citations

Early plasma-membrane-potential changes during stimulation of lymphocytes by concanavalin A.

1983 • 67 citations

Flow cytometric probes of early events in cell activation

1981 • 66 citations

Flow cytometric measurements of fluorescence energy transfer using single laser excitation

1987 • 66 citations

A cyanine dye distinguishes between cycling and non-cycling fibroblasts

1981 • 62 citations

Altered K ⁺ Channel Expression in Abnormal T Lymphocytes from Mice with the lpr Gene Mutation

1986 • 62 citations

B cell activation. VII. Independent and synergistic effects of mobilized calcium and diacylglycerol on membrane potential and I-A expression.

1986 • 61 citations

Structural studies on the membrane-bound immunoglobulin E (IgE)-receptor complex. 2. Mapping of distances between sites on IgE and the membrane surface

1983 • 60 citations

A potassium ionophore (valinomycin) inhibits lymphocyte proliferation by its effects on the cell membrane.

1976 • 55 citations

Potassium channels in human NK cells are involved in discrete stages of the killing process.

1986 • 55 citations

Fluorescence energy transfer between cobra alpha-toxin molecules bound to the acetylcholine receptor.

1984 • 54 citations

Voltage‐sensitive cyanine dye fluorescence signals in lymphocytes: Plasma membrane and mitochondrial components

1985 • 54 citations

Energy-transfer study of cytochrome b5 using the anthroyloxy fatty acid membrane probes

1985 • 53 citations

Membrane potential changes during IgE-mediated histamine release from rat basophilic leukemia cells

1983 • 51 citations

Chapter 2 Molecular motions and membrane organization and function

1981 • 51 citations

Concanavalin A causes an increase in sodium permeability and intracellular sodium content of pig lymphocytes

1983 • 49 citations

Association between transplantation antigens and a viral membrane protein synthesized from a mammalian expression vector

1983 • 48 citations

Membrane potential of mitochondria in intact lymphocytes during early mitogenic stimulation

1984 • 48 citations

Lateral Diffusion of Surface Molecules in Animal Cells and Tissues

1981 • 47 citations

Long-range lipid-protein interactions. Evidence from time-resolved fluorescence depolarization and energy-transfer experiments with bacteriorhodopsin-dimyristoylphosphatidylcholine vesicles

1985 • 45 citations

Complex formation of class I transplantation antigens and a viral glycoprotein.

1983 • 44 citations

Action of a phorbol ester on B-cells: potentiation of stimulant-induced electrical activity

1985 • 43 citations

Selective and unidirectional membrane redistribution of an H-2 antigen with an antibody-clustered viral antigen: relationship to mechanisms of cytotoxic T-cell interactions.

1979 • 43 citations

Role of extracellular Na and K in lymphocyte activation

1982 • 43 citations

Lateral diffusion in membranes

1983 • 43 citations

B cell activation. II. Receptor cross-linking by thymus-independent and thymus-dependent antigens induces a rapid decrease in the plasma membrane potential of antigen-binding B lymphocytes.

1983 • 39 citations

Cyclosporin A depolarizes cytoplasmic membrane potential and interacts with Ca2+ ionophores

1986 • 39 citations

Lipid mixing during freeze-thawing of liposomal membranes as monitored by fluorescence energy transfer

1983 • 38 citations

Association of Mouse Major Histocompatibility and Rauscher Murine Leukaemia Virus Envelope Glycoprotein Antigens on Leukaemia Cells and their Recognition by Syngeneic Virus‐Immune‐Cytotoxic T‐Lymphocytes

1978 • 37 citations

Quantitation of the förster energy transfer for two-dimensional systems

1981 • 36 citations

Surface mapping of mouse thymocytes.

1979 • 36 citations

Moloney Virus-Induced Cell Surface Antigens and Histocompatibility Antigens Are Located on Distinct Molecules

1979 • 35 citations

Cytosol-Membrane Interface of Human Erythrocytes

1983 • 35 citations

Activation and proliferation signals in mouse B cells. IV. Concanavalin A stimulates B cells to leave G0, but not to proliferate.

1984 • 34 citations

Lactoperoxidase-catalyzed iodination of the receptor for immunoglobulin E at the cytoplasmic side of the plasma membrane.

1984 • 34 citations

Mapping of lymphocyte surface polypeptide antigens by chemical cross-linking with BSOCOES.

1980 • 32 citations

Fluorescence energy transfer from diphenylhexatriene to bacteriorhodopsin in lipid vesicles

1983 • 32 citations

The use of fluorescence energy transfer to distinguish between poly(ethylene glycol)-induced aggregation and fusion of phospholipid vesicles

1983 • 31 citations

Dynamics of biochemical systems

1987 • 31 citations

Diffusion and aggregation in biological membranes

1984 • 31 citations

Quantitation of the förster energy transfer for two-dimensional systems

1981 • 31 citations

Use of energy transfer to assay the asseciation of proteins with lipid membranes

1977 • 30 citations

Influence of (dl)-propranolol and Ca2+ on membrane potential and amino acid transport in Ehrlich ascites tumor cells

1978 • 30 citations

A simplified approach to resonance energy transfer in membranes, lipoproteins and spatially restricted systems

1983 • 28 citations

Growth regulation by ion fluxes.

1980 • 28 citations

The use of fluorescent dyes to measure membrane potentials: A critique

1982 • 28 citations

The use of flurescent dyes to measure membrane potentials: A response

1982 • 28 citations

Cytoplasmic membrane potential of mouse lymphocytes is decreased by cyclosporins

1986 • 27 citations

Resonance energy transfer as a monitor of membrane protein domain segregation: application to the aggregation of bacteriorhodopsin reconstituted into phospholipid vesicles

1984 • 26 citations

Decreased membrane potential of T lymphocytes in ageing mice: flow cytometric studies with a carbocyanine dye.

1985 • 26 citations

QUANTITATIVE CHARACTERIZATION OF THE LATERAL DISTRIBUTION OF MEMBRANE PROTEINS WITHIN THE LIPID BILAYER

1982 • 25 citations

Electrophysiology of T lymphocyte cholinergic receptors.

1980 • 25 citations

The transverse location of tryptophan residues in the purple membranes of Halobacterium halobium studied by fluorescence quenching and energy transfer

1984 • 24 citations

Calcium-promoted fusion of isolated chromaffin granules detected by resonance energy transfer between labeled lipids embedded in the membrane bilayer

1984 • 22 citations

Fluorescence resonance energy transfer on the voltage-dependent sodium channel. Spatial relationship and site coupling between the batrachotoxin and Leiurus quinquestriatus quinquestriatus alpha-scorpion toxin receptors.

1984 • 21 citations

The Association between Class-I Transplantation Antigens and an Adenovirus Membrane Protein

1984 • 21 citations

The effects of ionophore A23187 and concanavalin A on the membrane potential of human peripheral blood lymphocytes and rat thymocytes

1985 • 20 citations

Accessibility of cell surface thiols in human lymphocytes is altered by ionophores or OKT-3 antibody

1986 • 20 citations

Fluorescence resonance energy transfer study of the associative state of membrane-bound complexes of complement proteins C5b-8.

1985 • 19 citations

Lymphocyte activation by OKT3: cyclosporine sensitivity and synergism with phorbol ester.

1986 • 19 citations

Interactions between lymphocyte membrane molecules. I. Interaction between B lymphocyte surface IgM and Fc IgG receptors requires ligand occupancy of both receptors.

1981 • 19 citations

Lipid and Protein Interactions in Ca++-Promoted Aggregation and Fusion of Chromaffin Granule Membranes

1982 • 19 citations

Mobility modulation by local concanavalin A binding. Selectivity toward different membrane proteins.

1984 • 19 citations

Association of Sendai virion envelope and a mouse surface membrane polypeptide on newly infected cells: lack of association with H-2K/D or alteration of viral immunogenicity.

1982 • 18 citations

Calcium-promoted resonance energy transfer between fluorescently labeled proteins during aggregation of chromaffin granule membranes

1982 • 17 citations

Fluorescence Photoactivation and Dissipation (FPD)

1986 • 16 citations

Evidence for reversible microclustering of lentil lectin membrane receptors on HeLa cells

1980 • 16 citations

Regulation of TCGF production in T cells. II. Early membrane events after anti-Thy-1 binding by the TCGF-producing T lymphoma EL-4 G-12.

1984 • 15 citations

Double labeling of lipoprotein receptors in fibroblast cell surface replicas

1984 • 15 citations

Biochemical analysis of ligand-induced receptor patching and capping using a novel immunolactoperoxidase iodination technique.

1979 • 15 citations

MACROMOLECULAR DYNAMICS AND INFORMATION TRANSFER

1981 • 15 citations

Excitation energy transfer from tryptophan residues of peptides and intrinsic proteins to diphenylhexatriene in phospholipid vesicles and biological membranes

1983 • 14 citations

Lectin receptor proximity on HL‐60 leukemia cells determined by fluorescence energy transfer using flow cytometry

1984 • 13 citations

Energy transfer in artificial membrane systems. Singlet-singlet energy transfer from alloxazines to isoalloxazines in dipamitoyl phosphatidylcholine liposomes and dialkylammonium chloride vesicles

1980 • 11 citations

Interdependent membrane mobility of human MHC coded antigens detected by monoclonal antibodies to various epitopes on class I and II molecules

1985 • 11 citations

Resonance energy transfer studies of the mechanisms of microclustering of lentil lectin membrane receptors on HeLa cells

1981 • 10 citations

Fluorescence energy transfer between ionophore, A23187, and membrane proteins of isolated outer and cytoplasmic membranes of a Gram-negative bacterium

1985 • 9 citations

Influence of Ca2+ on the plasma membrane potential and electrogenic uptake of glycine by myeloma cells. Involvement of a Ca2+-activated K+ channel

1985 • 8 citations

A general method for heterokaryon detection using resonance energy transfer and a fluorescence-activated cell sorter.

1982 • 8 citations

Changes in the distribution of platelet membrane proteins revealed by energy transfer

1984 • 7 citations

The thickness of air-dried human erythrocyte membranes as determined by energy transfer

1973 • 7 citations