Growth Hormone Secretagogues Stimulate the Hypothalamic-Pituitary-Adrenal Axis and Are Diabetogenic in the Zucker Diabetic Fatty Rat¹

A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release

1996 • 2,048 citations

Treatment of adults with growth hormone (GH) deficiency with recombinant human GH.

1993 • 845 citations

On thein Vitroandin VivoActivity of a New Synthetic Hexapeptide that Acts on the Pituitary to Specifically Release Growth Hormone*

1984 • 652 citations

Recombinant human insulin-like growth factor I stimulates growth and has distinct effects on organ size in hypophysectomized rats.

1988 • 424 citations

Enhancement of the anabolic effects of growth hormone and insulin-like growth factor I by use of both agents simultaneously.

1993 • 336 citations

The Diabetic Zucker Fatty Rat

1983 • 335 citations

Growth Hormone (GH)-Releasing Peptide Stimulates GH Release in Normal Men and Acts Synergistically with GH-Releasing Hormone*

1990 • 315 citations

Evolution of β-Cell Dysfunction in the Male Zucker Diabetic Fatty Rat

1995 • 283 citations

Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects.

1996 • 256 citations

Growth restoration of insulin-deficient diabetic rats by recombinant human insulin-like growth factor I

1986 • 187 citations

Hereditary Obesity in the Rat Associated with High Serum Fat and Cholesterol.

1962 • 157 citations

Adaptation of the growth hormone and insulin-like growth factor-I axis to chronic and severe calorie or protein malnutrition.

1995 • 120 citations

Modulation of pulsatile GH release through a novel receptor in hypothalamus and pituitary gland.

1996 • 120 citations

Functional STAT 1 and 3 signaling by the leptin receptor (OB-R); reduced expression of the rat fatty leptin receptor in transfected cells.

1996 • 116 citations

Growth Hormone-Releasing Peptide-6 Stimulates Sleep, Growth Hormone, ACTH and Cortisol Release in Normal Man

1995 • 116 citations

Automated repetitive microsampling of blood: growth hormone profiles in conscious male rats

1986 • 109 citations

Activation of the Hypothalamo-Pituitary-Adrenal Axis by the Growth Hormone (GH) Secretagogue, GH-Releasing Peptide-6, in Rats

1997 • 104 citations

Mediation by the central nervous system is critical to the in vivo activity of the GH secretagogue L-692,585

1996 • 101 citations

Body Fat in Laron Syndrome Patients: Effect of Insulin-Like Growth Factor I Treatment

1993 • 81 citations

Effects of a 7-day treatment with a novel, orally active, growth hormone (GH) secretagogue, MK-677, on 24-hour GH profiles, insulin-like growth factor I, and adrenocortical function in normal young men.

1996 • 75 citations

Growth hormone secretagogues: characterization, efficacy, and minimal bioactive conformation.

1995 • 75 citations

Atypical Growth Hormone Releasing Peptides

1994 • 70 citations

In vitro characterization of four novel classes of growth hormone-releasing peptide.

1995 • 64 citations

Efficacy and specificity of L-692,429, a novel nonpeptidyl growth hormone secretagogue, in beagles.

1994 • 60 citations

The Effects of Repeated Daily Recombinant Human Insulin‐like Growth Factor I Administration in Adolescents with Type 1 Diabetes

1995 • 48 citations

Comparison of daily versus continuous administration of somatotropin on growth rate, feed intake, and body composition in intact female rats1

1995 • 41 citations

The obese growth hormone (GH)-deficient dwarf rat: body fat responses to patterned delivery of GH and insulin-like growth factor-I.

1996 • 40 citations

L-692,429, a nonpeptide growth hormone (GH) secretagogue, reverses glucocorticoid suppression of GH secretion.

1994 • 32 citations

Insulin-like growth factor-1 and growth hormone (GH) have distinct and overlapping anabolic effects in GH-deficient rats

1995 • 26 citations

A homologous radioimmunoassay for rat insulin-like growth factor-I (IGF-I): implications for studies of human IGF-I physiology.

1996 • 22 citations

Effects of coadministered growth hormone (GH)-releasing hormone and GH-releasing hexapeptide on maladaptive aspects of obesity in Zucker rats.

1992 • 20 citations

Oral growth hormone secretagogues--better than Alice in Wonderland's growth elixir?

1996 • 13 citations

The effect of repeated administration of hexarelin, a growth hormone releasing peptide, and growth hormone releasing hormone on growth hormone responsivity

1996 • 11 citations

Effects of 14-day infusions of growth hormone and/or insulin-like growth factor I on the obesity of growing Zucker rats.

1996 • 10 citations