Expression of Bax in relation to Bcl-2 and other predictive parameters in breast cancer

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Histological Grading and Prognosis in Breast Cancer

1957 • 2,897 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.

1993 • 959 citations

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

1995 • 832 citations

Identification of a p53-dependent negative response element in the bcl-2 gene.

1994 • 747 citations

Induction of apoptosis by the Bcl-2 homologue Bak

1995 • 738 citations

Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2.

1994 • 664 citations

Down-regulation of bcl-2 by p53 in breast cancer cells.

1994 • 479 citations

Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma.

1995 • 477 citations

The Bcl-2 Protein: a Prognostic Indicator Strongly Related to p53 Protein in Lymph Node-Negative Breast Cancer Patients

1994 • 461 citations

Immunohistochemical analysis of in vivo patterns of Bcl-X expression.

1994 • 429 citations

Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells.

1995 • 422 citations

Bcl-XL and Bcl-2 repress a common pathway of cell death.

1995 • 406 citations

Bcl-2 protein expression and long-term survival in breast cancer.

1994 • 404 citations

bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer

1994 • 326 citations

Expression of the bcl‐2 gene family in normal and malignant breast tissue: Low bax‐α expression in tumor cells correlates with resistance towards apoptosis

1995 • 242 citations

Immunocytochemical localization of fos protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy

1995 • 208 citations

Prognostic value of bcl-2 expression in invasive breast cancer

1995 • 192 citations

Paradoxical inhibition of solid tumor cell growth by bcl2.

1994 • 190 citations

Immunocytochemical localization of BCL‐2 protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy

1994 • 156 citations

The prevalence of BCL-2 immunoreactivity in breast carcinomas and its clinicopathological correlates, with particular reference to oestrogen receptor status

1994 • 126 citations

Regulation and function of Bcl-2 during differentiation-induced cell death in HL-60 promyelocytic cells.

1995 • 99 citations

Bcl‐2 expression is associated with lymph node metastasis in human ductal breast carcinoma

1995 • 99 citations

Bcl‐2 protooncogene expression in cervical carcinoma cell lines containing inactive p53

1995 • 76 citations

Modulation of Bcl-2 and Ki-67 expression in oestrogen receptor-positive human breast cancer by tamoxifen

1994 • 72 citations

c-erbB2 expression in correlation to other biological parameters of breast cancer

1990 • 60 citations

Heterodimerization with Bax is Required for Bcl-2 to Repress Cell Death

1995 • 57 citations

Bcl-2 protein expression in breast cancer in relation to established prognostic factors and other clinicopathological variables

1995 • 52 citations

Expression of BCL-2 in primary breast cancer and its correlation with tumour phenotype

1994 • 50 citations

EGF‐R and Overexpression of the Oncogene c‐erbB‐2 in Ovarian Cancer: Immunohistochemical Findings and Prognostic Value

1995 • 43 citations

Combinatorial Interaction of Human bcl-2 Related Proteins: Mapping of Regions Important for bcl-2/bcl-x-s Interaction

1995 • 25 citations