The use of a cloned bacterial gene to study mutation in mammalian cells

Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.

1981 • 1,048 citations

Expression of a Bacterial Gene in Mammalian Cells

1980 • 788 citations

Properties of a supercoiled deoxyribonucleic acid-protein relaxation complex and strand specificity of the relaxation event

1970 • 770 citations

The bidirectional transfer of DNA and RNA to nitrocellulose or diazobenzyloxymethyl-paper

1980 • 760 citations

Highly Repeated Sequences in Mammalian Genomes

1982 • 657 citations

Patterns of Integration of DNA Microinjected into Cultured Mammalian Cells: Evidence for Homologous Recombination Between Injected Plasmid DNA Molecules

1982 • 417 citations

Mapping temperature-sensitive and host-range mutations of adenovirus type 5 by marker rescue

1978 • 408 citations

Radiation-Induced Chromosome Damage in Man

1984 • 387 citations

The transfer and stable integration of the HSV thymidine kinase gene into mouse cells

1978 • 382 citations

Transforming DNA integrates into the host chromosome

1981 • 311 citations

Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules.

1982 • 281 citations

Mutation and Inactivation of Cultured Mammalian Cells Exposed to Beams of Accelerated Heavy Ions

1979 • 251 citations

The chromosomes of CHO, an aneuploid Chinese hamster cell line: G-band, C-band, and autoradiographic analyses

1973 • 249 citations

Altering Genotype and Phenotype by DNA-Mediated Gene Transfer

1980 • 242 citations

Linear dose —response relationships after prolonged expression times in V-79 Chinese hamster cells

1976 • 172 citations

A quantitative assay of mutation induction at the hypoxanthine-guanine phosphoribosyl transferase locus in Chinese hamster ovary cells (CHO/HGPRT system): Utilization with a variety of mutagenic agents

1977 • 151 citations

DNA sequence homology and chromosomal deletion at a site of SV40 DNA integration

1982 • 143 citations

Parameters governing the transfer of the genes for thymidine kinase and dihydrofolate reductase into mouse cells using metaphase chromosomes or DNA

1980 • 139 citations

Factors governing the expression of a bacterial gene in mammalian cells.

1981 • 126 citations

Mutation and Inactivation of Cultured Mammalian Cells Exposed to Beams of Accelerated Heavy Ions

1979 • 118 citations

A mutational assay system for L5178Y mouse lymphoma cells, using hypoxanthine-guanine-phosphoribosyl-transferase (HGPRT) -deficiency as marker. The occurrence of a long expression time for mutations induced by X-rays and EMS

1975 • 114 citations

Mutation induction and inactivation in mammalian cells exposed to ionising radiation

1975 • 104 citations

The induction of thioguanine-resistant mutants of Chinese hamster cells by γ-rays

1977 • 88 citations

Genetic markers for quantitative mutagenesis studies in Chinese hamster ovary cells Characteristics of some recently developed selective systems

1980 • 78 citations

Genetic and biochemical studies with the adenosine analogs toyocamycin and tubercidin: Mutation at the adenosine kinase locus in Chinese hamster cells

1978 • 72 citations

The chromosomes of a V79 Chinese hamster line and a mutant subline lacking HPRT activity

1981 • 63 citations

Guanine phosphoribosyltransferase from Escherichia coli. Specificity and properties

1972 • 61 citations

Introduction and recovery of a selectable bacterial gene from the genome of mammalian cells.

1982 • 58 citations

Factors affecting the efficiency of purine analogues as selective agents for mutants of mammalian cells induced by ionising radiation

1976 • 57 citations

Direct demonstration of genetic alterations at the dihydrofolate reductase locus after gamma irradiation.

1982 • 44 citations

Alterations of Gene Structure in Ethyl Methane Sulfonate-Induced Mutants of Mammalian Cells

1982 • 41 citations

Karyotypic heterogeneity in CHO cell lines

1978 • 29 citations

Escherichia coli mutants deficient in guanine-xanthine phosphoribosyltransferase

1976 • 29 citations

A mouse-cell mutant sensitive to ionizing radiation is hypermutable by low doses of γ-radiation

1981 • 24 citations

A simple autoradiographic method for checking HGPRT-deficiency in colonies of mammalian cells

1982 • 14 citations

Chromosome structure and DNA sequence alterations associated with mutation of transformed genes.

1981 • 14 citations

Resistance to methyl mercaptopurine riboside in cultured hamster cells

1980 • 13 citations