Isoprostanes: Free Radical–Generated Prostaglandins With Constrictor Effects on Cerebral Arterioles

Reactive Oxygen Species and the Central Nervous System

1992 • 2,931 citations

Non-cyclooxygenase-derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids.

1992 • 742 citations

New Horizons

1979 • 624 citations

Ultra-early evaluation of regional cerebral blood flow in severely head-injured patients using xenon-enhanced computerized tomography.

1993 • 467 citations

The isoprostanes

1996 • 451 citations

Neuropathological sequelae of traumatic brain injury: relationship to neurochemical and biomechanical mechanisms.

1996 • 343 citations

Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanes.

1994 • 305 citations

Evidence for the existence of F2-isoprostane receptors on rat vascular smooth muscle cells

1993 • 260 citations

Brain Hydroxyl Radical Generation in Acute Experimental Head Injury

1993 • 226 citations

Detailed Description of a Cranial Window Technique for Acute and Chronic Experiments

1975 • 222 citations

Cerebral blood flow, cerebral blood volume, and cerebrovascular reactivity after severe head injury.

1992 • 220 citations

The F2-isoprostane, 8-epi-prostaglandin F2α, a potent agonist of the vascular thromboxane/endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonist

1992 • 214 citations

Recording of microvascular dimensions with an image-splitter television microscope.

1966 • 195 citations

Formation of F ₂ -Isoprostanes During Oxidation of Human Low-Density Lipoprotein and Plasma by Peroxynitrite

1995 • 161 citations

Identification of non-cyclooxygenase-derived prostanoid (F2-isoprostane) metabolites in human urine and plasma.

1993 • 158 citations

Continuous Monitoring of Posttraumatic Cerebral Blood Flow Using Laser-Doppler Flowmetry

1992 • 91 citations

Cerebrovascular actions of prostaglandins

1982 • 85 citations

Actions of the E2-isoprostane, 8-ISO-PGE2, on the platelet thromboxane/ endoperoxide receptor in humans and rats: Additional evidence for the existence of a unique isoprostane receptor

1994 • 84 citations

Vascular Smooth Muscle Actions and Receptor Interactions of 8-Iso-prostaglandin E2, an E2-Isoprostane

1993 • 84 citations

Stimulatory Effect of 8-Epi-PGF2α, An F2-Isoprostane, on Endothelin-1 Release

1995 • 83 citations

Stimulatory effect of 8-Epi-PGF2 alpha, an F2-isoprostane, on endothelin-1 release.

1995 • 81 citations

A reliable and sensitive enzyme immunoassay method for measuring 8-isoprostaglandin F2α: a marker for lipid peroxidation after experimental brain injury

1996 • 79 citations

Hemorrhagic Hypotension After Brain Injury Causes an Early and Sustained Reduction in Cerebral Oxygen Delivery Despite Normalization of Systemic Oxygen Delivery

1992 • 69 citations

Lazaroids

1995 • 66 citations

Role of prostaglandin H2-thromboxane A2 in responses of cerebral arterioles during chronic hypertension

1992 • 64 citations

Restoration of cerebrovascular responsiveness to hyperventilation by the oxygen radical scavenger n-acetylcysteine following experimental traumatic brain injury

1991 • 62 citations

Formation of PGF2-Isoprostanes During the Oxidative Modification of Low Density Lipoprotein

1994 • 59 citations

Generation and Detection of Hydroxyl Radical Following Experimental Head Injury

1994 • 54 citations

Intracellular Signaling by 8-epi-Prostaglandin F2αIs Mediated by Thromboxane A2/Prostaglandin Endoperoxide Receptors in Porcine Carotid Arteries

1996 • 41 citations

Superoxide Dismutase Improves Posttraumatic Cortical Blood Flow in Rats

1995 • 35 citations

Xenon 133 — CBF Measurements in Severe Head Injury and Subarachnoid Haemorrhage

1993 • 35 citations

The isoprostanes: novel markers of lipid peroxidation and potential mediators of oxidant injury.

1995 • 30 citations

Histidine attenuates cerebral vasospasm in a rabbit model of subarachnoid hemorrhage

1995 • 28 citations

Constriction of Pial Arterioles Produced by Prostaglandin F _2α

1975 • 27 citations

The effect of PGF2a on in vivo cerebral arteriolar diameter in cats and rats

1983 • 26 citations

Transcranial Doppler-Sonography in Severe Head Injury

1993 • 23 citations

Pharmacologic therapy for traumatic brain injury: experimental approaches.

1995 • 23 citations

Experimental subarachnoid hemorrhage: Events related to anti-oxidant enzymatic systems and eicosanoid peroxide enhancement

1994 • 22 citations

Efficacy of steroid hormone in solution for intracranial irrigation during aneurysmal surgery for prevention of the vasospasm syndrome

1994 • 18 citations

Effect of thromboxane A2/endoperoxide antagonist SQ29548 on the contractile response to acetylcholine in newborn piglet cerebral arteries.

1990 • 17 citations

Changes in the Treatment of Head Injury

1991 • 10 citations