Neurotransmitter and neuromodulatory mechanisms involved in alcohol abuse and alcoholism

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

1988 • 4,617 citations

A psychomotor stimulant theory of addiction.

1987 • 2,704 citations

Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.

1983 • 2,376 citations

Neurogenetic Adaptive Mechanisms in Alcoholism

1987 • 2,300 citations

The membrane actions of anesthetics and tranquilizers.

1972 • 2,194 citations

Naltrexone in the Treatment of Alcohol Dependence

1992 • 1,875 citations

Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum

1975 • 1,741 citations

Ethanol Inhibits NMDA-Activated Ion Current in Hippocampal Neurons

1989 • 1,456 citations

Recent Developments in Alcoholism

1987 • 1,046 citations

Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors

1984 • 905 citations

Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol.

1986 • 852 citations

Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korsakoff's disease

1983 • 811 citations

Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area

1985 • 788 citations

Allelic Association of the D2 Dopamine Receptor Gene With Receptor-Binding Characteristics in Alcoholism or Gene ism

1991 • 656 citations

N‐Methyl‐D‐Aspartate Receptors and Ethanol: Inhibition of Calcium Flux and Cyclic GMP Production

1989 • 566 citations

Voluntary consumption of ethanol in 15 inbred mouse strains

1993 • 564 citations

Alcohol, Amines, and Alkaloids: A Possible Biochemical Basis for Alcohol Addiction

1970 • 558 citations

A proposed new nomenclature for 5-HT receptors

1993 • 551 citations

Moderate Prenatal Alcohol Exposure: Effects on Child IQ and Learning Problems at Age 7 1/2 Years

1990 • 549 citations

A Selective Imidazobenzodiazepine Antagonist of Ethanol in the Rat

1986 • 545 citations

Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes.

1986 • 543 citations

Marked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats

1992 • 525 citations

Alcohol stimulates the release of dopamine and serotonin in the nucleus accumbens

1992 • 510 citations

Ethanol increases the firing rate of dopamine neurons of the rat ventral tegmental area in vitro

1990 • 507 citations

Intracranial self-administration of morphine into the ventral tegmental area in rats

1981 • 497 citations

Alcohol Intoxication and Withdrawal

1976 • 481 citations

Genetic Selection for Voluntary Alcohol Consumption in the Albino Rat

1968 • 450 citations

Alteration of ethanol self-administration by naltrexone

1980 • 402 citations

The Biology of Alcoholism

1983 • 383 citations

Suicidality and 5-Hydroxyindoleacetic Acid Concentration Associated With a Tryptophan Hydroxylase Polymorphism

1994 • 378 citations

Long-term potentiation as a candidate mnemonic device

1984 • 375 citations

Serotonin axon terminals in the ventral tegmental area of the rat: fine structure and synaptic input to dopaminergic neurons

1987 • 374 citations

Alcohol and Central Serotonin Metabolism in Man

1979 • 368 citations

Involvement of N‐methyl‐D‐aspartate receptors in epileptiform bursting in the rat hippocampal slice.

1986 • 365 citations

Ethanol and the Nervous System

1989 • 362 citations

NMDA receptor-mediated synaptic excitation selectively inhibited by ethanol in hippocampal slice from adult rat

1990 • 360 citations

Ethanol sensitivity of the GABAA receptor expressed in xenopus oocytes requires 8 amino acids contained in the γ2L subunit

1991 • 353 citations

Action of drugs of abuse on brain reward systems

1980 • 330 citations

5-HT and alcohol abuse

1992 • 327 citations

Ethanol Specifically Potentiates GABA-Mediated Neurotransmission in Feline Cerebral Cortex

1980 • 322 citations

SELF-STIMULATION OF THE BRAIN AND THE CENTRAL STIMULANT ACTION OF AMPHETAMINE.

1964 • 313 citations

Effect of ethanol on the hydroxylation of tyrosine and tryptophan in rat brain in vivo

1973 • 312 citations

Profound decrement of mesolimbic dopaminergic neuronal activity during ethanol withdrawal syndrome in rats: electrophysiological and biochemical evidence.

1993 • 308 citations

Serotonin, dopamine and GABA involvement in alcohol drinking of selectively bred rats

1990 • 301 citations

Morphological Alterations in Hippocampus After Long-Term Alcohol Consumption in Mice

1978 • 292 citations

Contents of monoamines in forebrain regions of alcohol-preferring (P) and -nonpreferring (NP) lines of rats

1987 • 289 citations

Population and Pedigree Studies Reveal a Lack of Association Between the Dopamine D2 Receptor Gene and Alcoholism

1990 • 280 citations

Differential inhibitory effects of a 5-HT3 antagonist on drug-induced stimulation of dopamine release

1989 • 277 citations

Alcohol and the Brain

1990 • 276 citations

The A1 Allele at the D2 Dopamine Receptor Gene and Alcoholism

1993 • 274 citations

Acute and chronic ethanol treatments alter GABA receptor-operated chloride channels

1987 • 264 citations

Aging of the brain and dementia

1980 • 259 citations

Cholinergic system and memory in the rat: Effects of chronic ethanol, embryonic basal forebrain brain transplants and excitotoxic lesions of cholinergic basal forebrain projection system

1989 • 258 citations

Naltrexone reverses ethanol-induced dopamine release in the nucleus accumbens in awake, freely moving rats

1993 • 242 citations

NEW STRAINS OF RATS WITH ALCOHOL PREFERENCE AND NONPREFERENCE

1977 • 241 citations

Alcohol and Aldehyde Metabolizing Systems-IV

1980 • 241 citations

Free-choice responding for ethanol versus water in alcohol preferring (P) and unselected Wistar rats is differentially modified by naloxone, bromocriptine, and methysergide

1990 • 237 citations

Rapid Communication Chronic Ingestion of Ethanol Up‐Regulates NMDAR1 Receptor Subunit Immunoreactivity in Rat Hippocampus

1994 • 235 citations

Dopamine-containing neurons in the mammalian central nervous system: Electrophysiology and pharmacology

1988 • 233 citations

Importance of delta opioid receptors in maintaining high alcohol drinking

1991 • 220 citations

Excitotoxicity and Alcohol‐Related Brain Damage

1993 • 219 citations

Chronic Ethanol Exposure Potentiates NMDA Excitotoxicity in Cerebral Cortical Neurons

1993 • 216 citations

Attenuation of hippocampal long-term potentiation by ethanol: a patch- clamp analysis of glutamatergic and GABAergic mechanisms

1993 • 215 citations

The effects of 6-hydroxydopamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat

1993 • 211 citations

Ethanol potentiation of 5-hydroxytryptamine3 receptor-mediated ion current in neuroblastoma cells and isolated adult mammalian neurons.

1991 • 210 citations

Ethanol stimulates the firing rate of nigral dopaminergic neurons in unanesthetized rats

1984 • 208 citations

Ethanol inhibits NMDA-activated current but does not alter GABA-activated current in an isolated adult mammalian neuron

1990 • 207 citations

Autoradiographic analysis of serotonin 5-HT1A receptor binding in the human brain postmortem: effects of age and alcohol

1991 • 200 citations

Intragastric Self-Infusion of Ethanol by Ethanol-Preferring and -Nonpreferring Lines of Rats

1984 • 192 citations

Ethanol potentiates GABA- and glycine-induced chloride currents in chick spinal cord neurons

1988 • 192 citations

Serotonin microinfusion into the ventral tegmental area increases accumbens dopamine release

1989 • 191 citations

Alterations in γ‐Aminobutyric Acid Receptor Sensitivity Following Acute and Chronic Ethanol Treatments

1980 • 188 citations

Chronic exposure of cerebellar granule cells to ethanol results in increased N-methyl-D-aspartate receptor function.

1992 • 187 citations

Regional brain contents of serotonin, dopamine and their metabolites in the selectively bred high- and low-alcohol drinking lines of rats

1989 • 183 citations

No Structural Mutation in the Dopamine D2 Receptor Gene in Alcoholism or Schizophrenia

1994 • 182 citations

Antibodies Specific for GABA_A Receptor α Subunits Reveal that Chronic Alcohol Treatment Down‐Regulates α‐Subunit Expression in Rat Brain Regions

1993 • 179 citations

Effect of dopamine agonists and antagonists on ethanol-reinforced behavior: The involvement of the nucleus accumbens

1993 • 179 citations

Loss of neurons in the rat basal forebrain cholinergic projection system after prolonged intake of ethanol

1988 • 173 citations

Prolonged ethanol inhalation decreases gamma-aminobutyric acidA receptor alpha subunit mRNAs in the rat cerebral cortex.

1991 • 169 citations

Densities of dopamine D2 receptors are reduced in CNS regions of alcohol-preferring P rats

1993 • 166 citations

Effect of spontaneous ingestion of ethanol on brain dopamine metabolism

1989 • 163 citations

Benzodiazepine agonist and inverse agonist actions on GABAA receptor-operated chloride channels. II. Chronic effects of ethanol.

1990 • 163 citations

Ethanol Inhibition of N‐Methyl‐D‐Aspartate‐Stimulated Endogenous Dopamine Release from Rat Striatal Slices: Reversal by Glycine

1990 • 162 citations

The effect of intraventricular administration of the 5-HT3 receptor agonist 2-methylserotonin on the release of dopamine in the nucleus accumbens: an in vivo chronocoulometric study

1990 • 160 citations

Behavioral Studies of Alcoholism

1972 • 157 citations

Haloperidol and apomorphine effects on ethanol reinforcement in free feeding rats

1988 • 156 citations

Radioligand binding to the N-methyl-d-aspartate receptor/ionophore complex: alterations by ethanol in vitro and by chronic in vivo ethanol ingestion

1993 • 154 citations

MDL 72222, A SELECTIVE 5-HT3 RECEPTOR ANTAGONIST, SUPPRESSES VOLUNTARY ETHANOL CONSUMPTION IN ALCOHOL-PREFERRING RATS

1991 • 152 citations

Effects of D1 and D2 dopamine receptor agents on ethanol consumption in the high-alcohol-drinking (HAD) line of rats

1993 • 151 citations

Alcohol Preference in the Rat: Reduction Following Depletion of Brain Serotonin

1968 • 150 citations

Molecular basis for regionally specific action of ethanol on gamma-aminobutyric acidA receptors: generalization to other ligand-gated ion channels.

1993 • 149 citations

Modulation of excitatory synaptic transmission by glycine and zinc in cultures of mouse hippocampal neurons

1988 • 146 citations

The effect of ethanol on the activity of central catecholamine neurones in rat brain

1966 • 144 citations

The effects of cholinergic drugs and cholinergic-rich foetal neural transplants on alcohol-induced deficits in radial maze performance in rats

1991 • 142 citations

Effects of Ro 15-4513, fluoxetine and desipramine on the intake of ethanol, water and food by the alcohol-preferring (P) and -nonpreferring (NP) lines of rats

1988 • 140 citations

Buspirone in the Treatment of Alcoholic Patients

1989 • 137 citations

Bidirectional selection for susceptibility to ethanol withdrawal seizures inMus musculus

1985 • 136 citations

Modulation of ethanol intake by serotonin uptake inhibitors.

1986 • 136 citations

Involvement of μ-opioid receptors in alcohol drinking by alcohol-preferring AA rats

1993 • 136 citations

Glycine site-directed agonists reverse the actions of ethanol at the N-methyl-D-aspartate receptor.

1990 • 136 citations

The dexamethasone suppression test and response to somatic treatment: a review.

1986 • 133 citations

Naloxone-induced inhibition of ethanol dependence in mice

1977 • 130 citations

Regulation of nucleus accumbens dopamine release by the dorsal raphe nucleus in the rat

1992 • 129 citations

Inhibition of NMDA-evoked electrophysiological activity by ethanol in selected brain regions: evidence for ethanol-sensitive and ethanol-insensitive NMDA-evoked responses

1993 • 128 citations

Blockade of δ-opioid receptors in the nucleus accumbens prevents ethanol-induced stimulation of dopamine release

1993 • 128 citations

Discriminative stimulus effects of ethanol: effect of training dose on the substitution of N-methyl-D-aspartate antagonists.

1993 • 127 citations

Genetic predisposition in alcoholism: Association of the D2 dopamine receptor TaqI B1 RFLP with severe alcoholics

1993 • 124 citations

Responding for Oral Ethanol after Naloxone Treatment by Alcohol‐Preferring AA Rats

1993 • 121 citations

Citalopram decreases desirability, liking, and consumption of alcohol in alcohol-dependent drinkers

1992 • 118 citations

Chronic Ethanol Treatment Alters Brain Levels of γ‐Aminobutyric Acid_A Receptor Subunit mRNAs: Relationship to Genetic Differences in Ethanol Withdrawal Seizure Severity

1991 • 117 citations

Alcohol intoxication: ion channels and genetics

1989 • 116 citations

Immunostained serotonergic fibers are decreased in selected brain regions of alcohol-preferring rats

1991 • 112 citations

RAPID COMMUNICATION: ALCOHOL-PREFERRING RATS HAVE FEWER DOPAMINE D<sub>2</sub> RECEPTORS IN THE LIMBIC SYSTEM

1992 • 110 citations

Prenatal ethanol exposure during the last third of gestation in rat reduces hippocampal NMDA agonist binding site density in 45-day-old offspring

1992 • 109 citations

Experimentally Induced Changes in the Free Selection of Ethanol

1960 • 109 citations

Systemic Ethanol: Selective Enhancement of Responses to Acetylcholine and Somatostatin in Hippocampus

1986 • 109 citations

Zacopride, a 5-HT3 receptor antagonist, reduces voluntary ethanol consumption in rats

1992 • 108 citations

The dopamine-releasing actions of neuroleptics and ethanol.

1974 • 107 citations

Differences in the Brain and Pituitary β‐Endorphin System between the Alcohol‐Preferring AA and Alcohol‐Avoiding ANA Rats

1992 • 107 citations

Alcohol drinking in the rat after destruction of serotonergic and catecholaminergic neurons in the brain.

1975 • 106 citations

Blockade of the discriminative stimulus effects of ethanol with 5-HT3 receptor antagonists

1991 • 103 citations

Ethanol Modulation of Opiate Receptors in Cultured Neural Cells

1983 • 101 citations

Measurement of alcohol preference in genetic experiments.

1964 • 101 citations

Bromocriptine in the prevention of alcohol abuse

1983 • 101 citations

Opioidergic, serotonergic, and dopaminergic manipulations and rats' intake of a sweetened alcoholic beverage

1991 • 100 citations

Effects of acute and chronic ethanol intake on synaptosomal glutamate binding activity

1978 • 97 citations

Chronic ethanol administration increases the binding of the benzodiazepine inverse agonist and alcohol antagonist [3H]RO15-4513 in rat brain

1988 • 96 citations

Microinjections of dopamine agonists in the nucleus accumbens increase ethanol-reinforced responding

1992 • 94 citations

Stress and alcohol use

1983 • 93 citations

Ventral Tegmental Microinjections of Quinpirole Decrease Ethanol and Sucrose‐Reinforced Responding

1993 • 92 citations

Tests of opioid deficiency hypotheses of alcoholism

1991 • 90 citations

Buspirone attenuates volitional alcohol intake in the chronically drinking monkey

1987 • 89 citations

Brain regional and adrenal monoamine concentrations and behavioral responses to stress in alcohol-preferring AA and alcohol-avoiding ANA rats

1988 • 88 citations

The D2 dopamine receptor gene: A review of association studies in alcoholism

1993 • 87 citations

The competitive NMDA receptor antagonist, CGP 39551, inhibits ethanol withdrawal seizures

1991 • 87 citations

Short-term memory impairment following chronic alcohol consumption in rats

1978 • 85 citations

Ethanol prevents the glutamate release induced by in the rat striatum

1993 • 85 citations

Tolerance to and cross-tolerance among ethanol, pentobarbital and chlordiazepoxide

1986 • 84 citations

Ethanol preference in the rat: interactions between brain serotonin and ethanol, acetaldehyde, paraldehyde, 5-HTPand 5-HTOL

1972 • 83 citations

Ethanol inhibition of N-methyl-d-aspartate-activated ion current in rat hippocampal neurons is not competitive with glycine

1992 • 82 citations

Comparative Aspects of Tolerance to, and Dependence on, Alcohol, Barbiturates and Opiates

1977 • 82 citations

Intragastric Intubation of Alcohol During Postnatal Development of Rats Results in Selective Cell Loss in the Cerebellum

1993 • 81 citations

High ethanol sensitivity of recombinant AMPA-type glutamate receptors expressed in mammalian cells

1993 • 80 citations

Comparison of ethanol sensitivity of rat brain kainate, DL-alpha-amino-3-hydroxy-5-methyl-4-isoxalone proprionic acid and N-methyl-D-aspartate receptors expressed in Xenopus oocytes.

1992 • 80 citations

Ethanol‐Induced Increase in Endogenous Dopamine Release May Involve Endogenous Opiates

1992 • 79 citations

Enhancement of NMDA toxicity and calcium responses by chronic exposure of cultured cortical neurons to ethanol

1994 • 77 citations

Serotonin Uptake Blockers and Voluntary Alcohol Consumption

1989 • 77 citations

Higher density of serotonin-1A receptors in the hippocampus and cerebral cortex of alcohol-preferring P rats

1990 • 76 citations

Ethanol acceptance as a function of genotype amounts of brain [Met]enkephalin.

1983 • 76 citations

Involvement of Neuronal Chloride Channels in Ethanol Intoxication, Tolerance, and Dependence

1987 • 74 citations

Microinjection of sulpiride into the nucleus accumbens increases ethanol drinking in alcohol-preferring (P) rats.

1991 • 73 citations

Acute withdrawal after repeated ethanol treatment reduces the number of spontaneously active dopaminergic neurons in the ventral tegmental area

1993 • 73 citations

Neuroscience Research: How Has It Contributed to Our Understanding of Alcohol Abuse and Alcoholism? A Review

1993 • 73 citations

NMDA receptors in mice bred to be prone or resistant to ethanol withdrawal seizures

1990 • 72 citations

EFFECTS OF VARIOUS SEROTONERGIC AGENTS ON ALCOHOL INTAKE AND ALCOHOL PREFERENCE IN WISTAR RATS SELECTED AT TWO DIFFERENT LEVELS OF ALCOHOL PREFERENCE

1993 • 72 citations

Cross-tolerance between ethanol and morphine with respect to their hypothermic effects

1979 • 72 citations

Monoamine Oxidase Inhibition by Ethanol in vitro

1962 • 70 citations

SDZ-205,152, a novel dopamine receptor agonist, reduces oral ethanol self-administration in rats

1993 • 70 citations

The effects of selective catecholamine depletions by 6-hydroxydopamine on ethanol preference in rats

1977 • 69 citations

Ipsapirone and 8-OH-DPAT reduce ethanol preference in rats: involvement of presynaptic 5-HT1A receptors

1993 • 69 citations

5-Hydroxytryptamine and 5-hydroxyindolylacetic acid content in brain of rat strains selected for their alcohol intake

1972 • 68 citations

Platelets 3H 5-HT uptake in descendants from alcoholic patients: A potential risk factor for alcohol dependence?

1993 • 68 citations

Decrease of benzodiazepine receptors in frontal cortex of alcoholics

1988 • 66 citations

Adaptive changes of dopamine-D2 receptors in rat brain following ethanol withdrawal: A quantitative autoradiographic investigation

1992 • 66 citations

Alcohol drinking attenuated by sertraline in rats with 6-OHDA or 5,7-DHT lesions of N. accumbens: A caloric response?

1991 • 62 citations

Further neuroendocrine evidence for reduced D2 dopamine receptor function in alcoholism

1993 • 62 citations

Effect of p-chlorophenylalanine on the acquisition of tolerance to ethanol and pentobarbital

1975 • 61 citations

Reduction in oral ethanol self-administration in the rat by the 5-HT uptake blocker fluoxetine

1990 • 61 citations

The abilities of 5-HT3 receptor antagonist ICS 205-930 to inhibit alcohol preference and withdrawal seizures in rats

1993 • 60 citations

Actions of drugs of abuse on brain reward systems: A reconsideration with specific attention to alcohol

1982 • 60 citations

A new alcohol antagonist: Phaclofen

1989 • 60 citations

Effects of 5-HT-1A receptor agonists on ethanol preference in the rat

1992 • 60 citations

Lack of effect of dopamine receptor blockade on voluntary ethanol consumption in rats

1982 • 59 citations

gamma-Aminobutyric acid-activated chloride channels: relationship to genetic differences in ethanol sensitivity.

1988 • 58 citations

Serotonin-2 receptors in the CNS of alcohol-preferring and -nonpreferring rats

1993 • 58 citations

Memory deficits following chronic alcohol consumption in mice: Relationships with hippocampal and cortical cholinergic activities

1992 • 58 citations

Serotonergic and adrenergic receptors in alcohol-preferring and non-preferring rats

1988 • 57 citations

Long-lasting suppression of alcohol preference in rats following serotonin receptor blockade by ritanserin

1992 • 57 citations

Long term ethanol alters the binding of 3H-opiates to brain membranes

1983 • 55 citations

Substitution of the 5-HT1 agonist trifluoromethylphenylpiperazine (TFMPP) for the discriminative stimulus effects of ethanol: effect of training dose

1993 • 54 citations

Loss of muscarinic and benzodiazepine neuroreceptors from hippocampus of alcohol abusers

1989 • 54 citations

Ethanol drinking following 6-OHDA lesions of nucleus accumbens and tuberculum olfactorium of the rat

1991 • 52 citations

Ethanol inhibits excitotoxicity in cerebral cortical cultures

1992 • 52 citations

Chronic ethanol treatment selectively increases the binding of inverse agonists for benzodiazepine binding sites in cultured spinal cord neurons.

1989 • 51 citations

Ethanol potentiates gamma-aminobutyric acid-mediated inhibition in the inferior colliculus: evidence for local ethanol/gamma-aminobutyric acid interactions.

1991 • 51 citations

Biogenic Amines, Biogenic Aldehydes, and Alcohol

1964 • 51 citations

Genetic Correlation of Ethanol‐induced Ataxia and Cerebellar Purkinje Neuron Depression among Inbred Strains and Selected Lines of Rats

1987 • 50 citations

Sex and strain differences in GABA receptor binding after chronic ethanol drinking in mice

1980 • 50 citations

The effect of lesions in the dorsal, median and magnus raphe nuclei on the development of tolerance to ethanol.

1981 • 50 citations

Dose- and Age-Dependent Effects of Prenatal Ethanol Exposure on Hippocampal Metabotropic-Glutamate Receptor-Stimulated Phosphoinositide Hydrolysis

1993 • 48 citations

Cholestyramine, clofibrate and nicotinic acid as single or combined treatment of type IIa and IIb hyperlipoproteinaemia.

1975 • 47 citations

5-HT2 receptor blockade by amperozide suppresses ethanol drinking in genetically preferring rats

1993 • 46 citations

5-Hydroxytryptophan-induced conditioned taste aversion to ethanol in the rat

1983 • 46 citations

Effect of Ethanol Administration and Withdrawal on Serotonin Receptor Subtypes and Receptor‐Mediated Phosphoinositide Hydrolysis in Rat Brain

1992 • 46 citations

Effect of ethanol on metabolism and subcellular distribution of serotonin in rat brain

1971 • 45 citations

Fluoxetine suppresses palatability-induced ingestion

1987 • 45 citations

Effect of chronic ethanol treatment on dopamine receptor subtypes in rat striatum

1988 • 45 citations

A Small Dose of Morphine Leads Rats to Drink More Alcohol and Achieve Higher Blood Alcohol Concentrations

1993 • 44 citations

The effect of in vitro and in vivo ethanol administration on [35S]t-Butylbicyclophosphorothionate binding in C57 mice

1985 • 44 citations

Platelet monoamine oxidase B: Use and misuse

1988 • 44 citations

A Comparison of the Effects of Ethanol and the Competitive Glycine Antagonist 7‐Chlorokynurenic Acid on N‐Methyl‐<scp>d</scp>‐Aspartic Acid‐Induced Neurotransmitter Release from Rat Hippocampal Slices

1994 • 43 citations

Effect of Ethanol Administration on Striatal D₁ and D₂ Dopamine Receptors

1988 • 43 citations

Ethanol attenuates the response of locus coeruleus neurons to excitatory amino acid agonists in vivo

1992 • 43 citations

The role of GABAB receptors in mediating the stimulatory effects of ethanol in mice

1993 • 43 citations

Diazepam Maintenance of Alcohol Preference During Alcohol Withdrawal

1977 • 42 citations

Possible Substrates of Ethanol Reinforcement: GABA and Dopamine

1992 • 42 citations

Binding of serotonergic ligands to brain membranes of alcohol-preferring AA and alcohol-avoiding ANA rats

1992 • 41 citations

Effect of l-tryptophan on the acquisition of tolerance to ethanol-induced motor impairment and hypothermia

1979 • 41 citations

Effect of modification of brain serotonin (5-HT), norepinephrine (NE) and dopamine (DA) on ethanol tolerance

1981 • 40 citations

Brain benzodiazepine binding sites in ethanol dependent and withdrawal states

1986 • 40 citations

Greater abundance of serotonin1A receptor in some brain areas of alcohol-preferring (P) rats compared to nonpreferring (NP) rats

1993 • 40 citations

Irreversible suppression of alcohol drinking in cyanamide-treated rats after sustained delivery of the 5-HT2 antagonist amperozide

1993 • 39 citations

Effects of chronic ethanol intake at a low dose on the rat brain dopaminergic system

1993 • 37 citations

The effect of neurotensin, TRH and the δ-opioid receptor antagonist ICI 174864 on alcohol-induced narcosis in rats

1987 • 37 citations

Ethanol inhibits the activity of the B form of monoamine oxidase in human platelet and brain tissue

1985 • 36 citations

Chronic morphine alters dopamine transporter density in the rat brain: Possible role in the mechanism of drug addiction

1993 • 36 citations

Selective agonists at NK3 tachykinin receptors inhibit alcohol intake in Sardinian alcohol-preferring rats

1994 • 35 citations

RAPID COMMUNICATION: BIPHASIC EFFECT OF ETHANOL ON NORADRENALINE RELEASE IN THE FRONTAL CORTEX OF AWAKE RATS

1992 • 35 citations

Failure of the 5-HT2 receptor antagonist, ritanserin, to alter preference for alcohol in drinking rats

1993 • 35 citations

Biochemical aspects of alcoholism

1976 • 35 citations

The 5-hydroxytryptamine stimulated formation of inositol phosphate is inhibited in platelets from alcoholics

1988 • 34 citations

Ethanol consumption following acute fenfluramine, fluoxetine, and dietary tryptophan

1993 • 34 citations

REDUCED [&lt;sup&gt;3&lt;/sup&gt;H]SCH 23390 BINDING AND DA-SENSITIVE ADENYLYL CYCLASE IN THE LIMBIC SYSTEM OF ETHANOL-PREFERRING RATS

1993 • 34 citations

Effects of the imidazobenzodiazepine RO15-4513 on the stimulant and depressant actions of ethanol on spontaneous locomotor activity

1988 • 34 citations

Ro 19-4603, A BENZODIAZEPINE RECEPTOR INVERSE AGONIST, ATFENUATES VOLUNTARY ETHANOL CONSUMPTION IN RATS SELECTIVELY BRED FOR HIGH ETHANOL PREFERENCE

1990 • 33 citations

Muscarinic and nicotinic receptor changes in the cortex and thalamus of brains of chronic alcoholics

1993 • 31 citations

Effect of sulpiride, an atypical neuroleptic, on apomorphine-induced growth hormone secretion

1982 • 31 citations

ALTERATIONS IN SEROTONIN RECEPTOR SUBTYPES IN ETHANOL-DEPENDENT RATS

1991 • 30 citations

Effects of serotonin uptake blockers and of 5-hydroxytryptophan on the voluntary consumption of ethanol, water and solid food by UChA and UChB rats

1990 • 30 citations

5‐Hydroxytryptophol in Human Cerebrospinal Fluid: Conjugation, Concentration Gradient, Relationship to 5‐Hydroxyindoleacetic Acid, and Influence of Hereditary Factors

1984 • 30 citations

The effect of p-chloroamphetamine on the consumption of ethanol by rats.

1970 • 29 citations

Ethanol inhibits the uptake of exogenous norepinephrine from the extracellular space of the rat cerebellum

1993 • 29 citations

Bidirectional changes in striatal D1-dopamine receptor density during chronic ethanol intake

1993 • 28 citations

Alcohol drinking in rats is attenuated by the mixed 5-HT1 agonist/5-HT2 antagonist FG 5893

1993 • 26 citations

Reduction in striatal 5-hydroxytryptamine turnover following chronic administration of ethanol to rats.

1987 • 26 citations

Ethanol differentially increases alpha 2-adrenergic and muscarinic acetylcholine receptor gene expression in NG108-15 cells.

1993 • 26 citations

Right ventricular dysfunction in human fetal compromise

1989 • 25 citations

Increased GH responsiveness to dopamine receptor stimulation in alcohol addicts during the late withdrawal syndrome

1983 • 25 citations

Housing conditions alter GABAA receptor of alcohol-preferring and -nonpreferring rats

1993 • 25 citations

Effect of ethanol on extracellular 5-hydroxytryptamine output in rat frontal cortex

1994 • 25 citations

5-HT1A receptor agonists reduce ethanol-induced locomotor activity in mice

1994 • 24 citations

Cholecystokinin and Bombesin Inhibit Ethanol and Food Intake in Rats Selectively Bred for Ethanol Sensitivity

1993 • 24 citations

Initial Sensitivity and Tolerance to Ethanol in Mice Genetically Selected for Diazepam Sensitivity

1988 • 24 citations

Chronic ethanol administration downregulates neurotensin receptors in long- and short-sleep mice

1993 • 24 citations

The effect of ethanol and haloperidol on dopamine receptor (D2) density

1987 • 23 citations

Hippocampal cholinergic alterations and related behavioral deficits after early exposure to ethanol

1993 • 22 citations

Fetal ethanol exposure diminishes hippocampal β-adrenergic receptor density while sparing muscarinic receptors during development

1990 • 22 citations

Alteration of GABAA receptor α1-subunit mRNA in mouse brain following continuous ethanol inhalation

1993 • 22 citations

Effects of Prenatal Ethanol Exposure on Hippocampal Ionotropic‐Quisqualate and Kainate Receptors

1992 • 22 citations

Comparative Effects of Ethanol and Malnutrition on the Development of Catecholamine Neurons: Changes in Norepinephrine Turnover

1980 • 22 citations

Loss of synaptic receptors can precede morphologic changes induced by alcoholism.

1991 • 21 citations

Differential response to flurazepam in long-sleep and short-sleep mice

1988 • 21 citations

Cholecystokinin and satiation with alcohol

1989 • 21 citations

Cholecystokinin octapeptide reduces ethanol intake in food- and water-sated rats

1990 • 21 citations

RAPID COMMUNICATION: TIANEPTINE, A SPECIFIC SEROTONIN UPTAKE ENHANCER, DECREASES ETHANOL INTAKE IN RATS

1992 • 20 citations

Responses of midbrain dorsal raphe neurons to ethanol studied in brainstem slices

1987 • 20 citations

Reduction of voluntary alcohol intake in the rat by modulation of the dopaminergic mesolimbic system: Transplantation of ventral mesencephalic cell suspensions

1994 • 19 citations

MONOAMINE OXIDASE ACTIVITY IN PLATELETS AS RELATED TO MONOAMINE OXIDASE ACTIVITY AND MONOAMINERGIC FUNCTION IN THE BRAIN

1981 • 19 citations

Cerebellar GABAA receptors in two rat lines selected for high and low sensitivity to moderate alcohol doses: Pharmacological and genetic studies

1992 • 18 citations

SEROTONIN-STIMULATED PHOSPHOINOSITIDE HYDROLYSIS IN PLATELETS FROM POST-WITHDRAWAL ALCOHOLICS

1992 • 17 citations

Effects of the combined administration of the 5-HT3 antagonist MDL 72222 and ethanol on conditioning in the periadolescent and adult rat

1993 • 17 citations

Response to selection for sensitivity to ethanol hypothermia: Genetic analyses

1990 • 16 citations

Effects of chronic ethanol on cholinergic actions in rat hippocampus: electrophysiological studies and quantification of m1-m5 muscarinic receptor subtypes

1993 • 16 citations

Dose‐Additive Inhibition of Intake of Ethanol by Cholecystokinin and Bombesin

1988 • 13 citations

Ethanol dose-dependently attenuates NMDA-mediated thermal hyperalgesia in the rat

1993 • 13 citations

Genetic-based differences in neurotensin levels and receptors in brains of LS × SS mice

1993 • 13 citations

Monoamine oxidase in mammalian blood platelets.

1965 • 13 citations

Effect of ethanol on brain catecholamines in rat lines developed for differential ethanol-induced motor impairment

1990 • 12 citations

5-Hydroxytryptamine and alcoholism

1991 • 12 citations

Regional catecholamine levels in brains of normal and ethanol-tolerant long-sleep and short-sleep mice

1991 • 11 citations

Microdialysis of extracellular noradrenaline in the hippocampus of the rat after long-term alcohol intake

1991 • 11 citations

Evidence for central alpha-2 adrenoceptors, not imidazoline binding sites, mediating the ethanol-attenuating properties of alpha-2 adrenoceptor antagonists.

1991 • 11 citations

Sensitivity to Strychnine Seizures Is Unaltered during Ethanol Withdrawal

1993 • 10 citations

Fenfluramine and 780SE in experimental alcoholism in rats.

1975 • 10 citations

A Comparison of Behavioral and Neurochemical Effects on Ethanol and Chlordiazepoxide

1980 • 10 citations

Effects of desipramine of rat behavior are prevented by concomitant treatment with ethanol

1989 • 9 citations

Reduction of Ethanol Intake by Aerosol Inhalation of a β‐Adrenergic Agonist: New Route–New Treatment Approach?

1993 • 9 citations

Fluvoxamine and Alcoholism

1991 • 9 citations

MODULATION OF ALCOHOL PREFERENCE BY NMDA ANTAGONISTS IN MALE RATS

1993 • 7 citations

MONOAMINE METABOLITES IN LUMBAR CEREBROSPINAL FLUID AND URINE IN ALCOHOLIC PATIENTS BEFORE AND AFTER TREATMENT WITH DISULFIRAM

1983 • 6 citations

TRIPTOSINE, AN L-5-HYDROXYTRYPTOPHAN DERIVATIVE, REDUCES ALCOHOL CONSUMPTION IN ALCOHOL-PREFERRING RATS

1992 • 6 citations

Effect of ethanol and progesterone on monoamine oxidase activity in cultured cells of human term placenta

1993 • 5 citations

Effects of acute administration of alcohol on in vivo binding of [3H]Ro 15-1788 to mouse brain.

1992 • 5 citations

CHANGES IN DRINKING BEHAVIOUR AND CHOLINERGIC BINDING S TES INDUCED BY INTERMITTENT LONG-TERM ETHANOL TREATMENT IN THE MALE RAT

1991 • 4 citations

Clinical conditions and central noradrenergic activity in long term abstinent alcoholic patients.

1987 • 4 citations

The effects of two different inhibitors of PNMT and their interactions with ethanol

1992 • 3 citations

Changes in brain muscarinic and beta-adrenoreceptors of the offspring of ethanol-consuming mothers (experiments on rats).

1991 • 2 citations

Acute ethanol intoxication may not alter α2-adrenoceptors in the human brain

1992 • 2 citations

Fluvoxamine : new perspectives in clinical practice

1991 • 1 citations

Deleted Work

1955 • 0 citations