Bax inhibition protects against free fatty acid-induced lysosomal permeabilization

Nonalcoholic Fatty Liver Disease

2002 • 5,091 citations

The Bcl2 family: regulators of the cellular life-or-death switch

2002 • 3,782 citations

Nonalcoholic fatty liver disease: A spectrum of clinical and pathological severity☆, ☆☆

1999 • 3,339 citations

The Natural History of Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study

2005 • 2,777 citations

Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome

2003 • 2,629 citations

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

2003 • 1,800 citations

Molecular mediators of hepatic steatosis and liver injury

2004 • 1,763 citations

Molecular mediators of hepatic steatosis and liver injury

2004 • 1,709 citations

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Lipotoxic heart disease in obese rats: Implications for human obesity

2000 • 1,257 citations

Fatty acid-induced β cell apoptosis: A link between obesity and diabetes

1998 • 1,142 citations

Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis

2003 • 1,033 citations

Nonalcoholic fatty liver disease

2002 • 894 citations

Lipotoxicity: when tissues overeat

2003 • 878 citations

Lipotoxic Diseases

2002 • 835 citations

Free fatty acids promote hepatic lipotoxicity by stimulating TNF-α expression via a lysosomal pathway

2004 • 787 citations

Obesity in the new millennium

2000 • 707 citations

Lysosomes in cell death

2004 • 683 citations

Nonionic Detergents Induce Dimerization among Members of the Bcl-2 Family

1997 • 583 citations

Bax in Murine Thymus Is a Soluble Monomeric Protein That Displays Differential Detergent-induced Conformations

1998 • 508 citations

Lipid overload and overflow: metabolic trauma and the metabolic syndrome

2003 • 390 citations

Cathepsin D targeted by acid sphingomyelinase-derived ceramide

1999 • 361 citations

Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice

2003 • 311 citations

Role of nitric oxide in obesity-induced beta cell disease.

1997 • 287 citations

Apoptosis in alcoholic and nonalcoholic steatohepatitis

2005 • 196 citations

Non‐alcoholic steatohepatitis: Definitions and pathogenesis

2002 • 185 citations

Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes

1997 • 185 citations

Tumor necrosis factor-α-associated lysosomal permeabilization is cathepsin B dependent

2002 • 179 citations

Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70

2003 • 157 citations

Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis.

2001 • 148 citations

Palmitic and stearic fatty acids induce caspase‐dependent and ‐independent cell death in nerve growth factor differentiated PC12 cells

2003 • 126 citations

Nonalcoholic fatty liver disease in the pediatric population: a review

2005 • 124 citations

Mechanisms of Lipoapoptosis

2002 • 120 citations

cAMP Dose-dependently Prevents Palmitate-induced Apoptosis by Both Protein Kinase A- and cAMP-Guanine Nucleotide Exchange Factor-dependent Pathways in β-Cells

2004 • 118 citations

TNF-α-mediated lysosomal permeabilization is FAN and caspase 8/Bid dependent

2004 • 110 citations

Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis

2003 • 108 citations

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2002 • 77 citations

Bax-inhibiting peptide derived from mouse and rat Ku70

2004 • 77 citations

Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G

2005 • 70 citations

Ankylosing spondylitis: what is the cost to society, and can it be reduced?

2002 • 2 citations