Efficient allelic exchange and transposon mutagenesis in Mycobacterium tuberculosis

Tuberculosis: Commentary on a Reemergent Killer

1992 • 1,400 citations

Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis

1990 • 1,231 citations

Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent.

1986 • 1,116 citations

Versatile suicide vectors which allow direct selection for gene replacement in Gram-negative bacteria

1993 • 970 citations

Selection of Bacterial Virulence Genes That Are Specifically Induced in Host Tissues

1993 • 671 citations

Molecular Koch's Postulates Applied to Microbial Pathogenicity

1988 • 636 citations

Cloning of an M. tuberculosis DNA fragment associated with entry and survival inside cells

1993 • 382 citations

In vivo growth characteristics of leucine and methionine auxotrophic mutants of Mycobacterium bovis BCG generated by transposon mutagenesis

1995 • 211 citations

Generation of unmarked directed mutations in mycobacteria, using sucrose counter‐selectable suicide vectors

1996 • 161 citations

Expression of the Bacillus subtilis sacB gene confers sucrose sensitivity on mycobacteria

1996 • 155 citations

Allelic exchange in Mycobacterium tuberculosis with long linear recombination substrates

1996 • 152 citations

Efficient transposition in mycobacteria: construction of Mycobacterium smegmatis insertional mutant libraries

1994 • 138 citations

Mutation of the principal sigma factor causes loss of virulence in a strain of the Mycobacterium tuberculosis complex.

1995 • 122 citations

Targeted replacement of the mycocerosic acid synthase gene in Mycobacterium bovis BCG produces a mutant that lacks mycosides.

1996 • 110 citations

Use of in vivo complementation in Mycobacterium tuberculosis to identify a genomic fragment associated with virulence

1994 • 101 citations

A novel transposon trap for mycobacteria: isolation and characterization of IS1096

1991 • 100 citations

The urease locus of Mycobacterium tuberculosis and its utilization for the demonstration of allelic exchange in Mycobacterium bovis bacillus Calmette-Guérin.

1995 • 95 citations

Gene expression in mycobacteria: transcriptional fusions based on xylE and analysis of the promoter region of the response regulator mtrA from Mycobacterium tuberculosis

1994 • 71 citations

Localized domains of DNA supercoiling: topological coupling between promoters

1996 • 60 citations

Temperature-sensitive mutants of the mycobacterium plasmid pAL5000

1992 • 59 citations

Gene replacement by homologous recombination in Mycobacterium bovis BCG

1995 • 54 citations

Positive selection of allelic exchange mutants inMycobacterium bovisBCG

1996 • 36 citations

The Mycobacterium tuberculosis purine biosynthetic pathway: isolation and characterization of the purC and purL genes

1996 • 33 citations

Advances in Mycobacterial Genetics: New Promises for Old Diseases

1992 • 29 citations

Tuberculosis of the Liver and Biliary Tract

1994 • 7 citations