Effects of the ortho-quinone and catechol of the antitumor drug VP-16-213 on the biological activity of single-stranded and double-stranded ΦX174 DNA

THREE LOCI IN ESCHERICHIA COLI K-12 THAT CONTROL THE EXCISION OF PYRIMIDINE DIMERS AND CERTAIN OTHER MUTAGEN PRODUCTS FROM DNA

1966 • 566 citations

Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage.

1984 • 463 citations

DNA damage as a basis for 4'-demethylepipodophyllotoxin-9-(4,6-O-ethylidene-beta-D-glucopyranoside) (etoposide) cytotoxicity.

1983 • 223 citations

Phenobarbital-induced rat liver cytochrome P-450. Purification and characterization of two closely related isozymic forms.

1982 • 221 citations

Effect of VP-16-213 on the intracellular degradation of DNA in HeLa cells

1976 • 197 citations

Oxidation of alpha-methyldopa and other catechols by cytochrome P-450-generated superoxide anion: possible mechanism of methyldopa hepatitis.

1976 • 152 citations

The podophyllotoxin derivatives VP16-213 and VM26

1982 • 146 citations

Spectrofluorimetric determination of catecholamines with 1,2-diphenylethylenediamine

1984 • 97 citations

The radiosensitivity of bacteriophage DNA in aqueous solution.

1967 • 79 citations

A rapid and mild procedure for the isolation of DNA from mammalian cells

1982 • 77 citations

In vitro metabolism of etoposide (VP-16-213) by liver microsomes and irreversible binding of reactive intermediates to microsomal proteins

1987 • 69 citations

Cytochrome P-450-mediated O-demethylation: a route in the metabolic activation of etoposide (VP-16-213).

1987 • 66 citations

Peroxidative free radical formation and O-demethylation of etoposide(VP-16) and teniposide(VM-26)

1986 • 63 citations

The Radiosensitivity of Bacteriophage DNA in Aqueous Solution

1967 • 58 citations

Construction of viable and lethal mutations in the origin of bacteriophage φX174 using synthetic oligodeoxyribonucleotides

1981 • 55 citations

Inhibition of etoposide-induced DNA damage and cytotoxicity in L1210 cells by dehydrogenase inhibitors and other agents.

1984 • 51 citations

Alkali-labile Sites and Post-irradiation Effects in Gamma-irradiated Biologically Active Double-stranded DNA in Aqueous Solution

1979 • 41 citations

A simple preparation of meso-stilbenediamine

1965 • 41 citations

Electrochemistry of podophyllotoxin derivatives

1985 • 41 citations

Effect of Oxygen on the Cytotoxicity and Antitumor Activity of Etoposide<xref ref-type="fn" rid="FN2">2</xref>

1985 • 36 citations

Microsomal interactions and inhibition of lipid peroxidation by etoposide (VP-16, 213): Implications for mode of action

1985 • 35 citations

Semi-Quinone Formation from the Catechol and Ortho-Quinone Metabolites of the Antitumor Agent VP-16–213

1988 • 27 citations

Interaction of oestrogen quinones with ethylene diamine

1963 • 24 citations

Inactivation of φX174 DNA by the ortho-quinone derivative or its reduction product of the antitumor agent VP 16-213

1985 • 23 citations

Some characteristics of apurinic sites in single- and double-stranded biologically active ϕX174 DNA

1981 • 18 citations

The role of metabolic activation by cytochrome P-450 in covalent binding of VP 16-213 to rat liver and HeLa cell microsomal proteins

1985 • 18 citations

Effects of adduct formation on the biological activity of single- and double-stranded φX174 DNA, modified by N-acetoxy-N-acetyl-2-aminofluorene

1984 • 17 citations

Free Radical Formation from the Antineoplastic Agent VP 16-213

1986 • 11 citations

Metabolic activation of the antitumor agent vp 16 213

1986 • 4 citations