Thrombomodulin Gene Mutations Associated With Myocardial Infarction

The Regulation of Natural Anticoagulant Pathways

1987 • 702 citations

The Sensitivity of Single-Strand Conformation Polymorphism Analysis for the Detection of Single Base Substitutions

1993 • 692 citations

Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation.

1982 • 434 citations

Thrombomodulin blocks the ability of thrombin to activate platelets.

1983 • 220 citations

Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control.

1987 • 126 citations

Disruption of a binding site for hepatocyte nuclear factor 4 results in hemophilia B Leyden.

1992 • 111 citations

Functional domains of membrane-bound human thrombomodulin. EGF-like domains four to six and the serine/threonine-rich domain are required for cofactor activity.

1992 • 105 citations

The first mutation identified in the thrombomodulin gene in a 45-year- old man presenting with thromboembolic disease

1995 • 95 citations

A Common Thrombomodulin Amino Acid Dimorphism Is Associated with Myocardial Infarction

1997 • 92 citations

Relationship between anticoagulant activities and polyanionic properties of rabbit thrombomodulin.

1988 • 81 citations

A Frequent Thrombomodulin Amino Acid Dimorphism Is not Associated with Thrombophilia

1991 • 63 citations

Two Mutations in the Promoter Region of the Human Protein C Gene Both Cause Type I Protein C Deficiency by Disruption of Two HNF-3 Binding Sites

1995 • 47 citations

Transcriptional regulation of the thrombomodulin gene

1992 • 37 citations

The effect of thrombomodulin on the cleavage of fibrinogen and fibrinogen fragments by thrombin

1987 • 33 citations

Functional Characterization of the 5'-Regulatory Region of the Human Thrombomodulin Gene1

1993 • 33 citations