Absence of the CD1 Molecule Up-Regulates Antitumor Activity Induced by CpG Oligodeoxynucleotides in Mice

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

Regulatory T Cells

2000 • 1,827 citations

MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function

1997 • 1,326 citations

Requirement for V _α 14 NKT Cells in IL-12-Mediated Rejection of Tumors

1997 • 1,226 citations

An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans.

1994 • 1,044 citations

CpG Oligodeoxynucleotides Act as Adjuvants that Switch on T Helper 1 (Th1) Immunity

1997 • 1,008 citations

Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants

1997 • 919 citations

CD1 Recognition by Mouse NK1 ⁺ T Lymphocytes

1995 • 903 citations

NKT cells: facts, functions and fallacies

2000 • 875 citations

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

1994 • 862 citations

Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain.

1993 • 714 citations

Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment

2000 • 697 citations

NKT cell–mediated repression of tumor immunosurveillance by IL-13 and the IL-4R–STAT6 pathway

2000 • 690 citations

CpG DNA Is a Potent Enhancer of Specific Immunity in Mice Immunized with Recombinant Hepatitis B Surface Antigen

1998 • 684 citations

CD1d1 Mutant Mice Are Deficient in Natural T Cells That PromptlyProduce IL-4

1997 • 612 citations

Requirements for CD1d Recognition by Human Invariant Vα24+ CD4−CD8− T Cells

1997 • 527 citations

Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization

1997 • 526 citations

Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes.

1995 • 517 citations

Immunoglobulin E Production in the Absence of Interleukin-4-Secreting CD1-Dependent Cells

1997 • 501 citations

Impaired NK1+ T Cell Development and Early IL-4 Production in CD1-Deficient Mice

1997 • 494 citations

Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity.

1992 • 480 citations

CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis.

1998 • 457 citations

An invariant V alpha 24-J alpha Q/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8- T cells.

1994 • 448 citations

CpG‐containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants

1997 • 390 citations

CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice.

1995 • 384 citations

CpG DNA Induces Sustained IL-12 Expression In Vivo and Resistance toListeria monocytogenesChallenge

1998 • 383 citations

KRN7000, a novel immunomodulator, and its antitumor activities.

1995 • 361 citations

NK1.1+ T cell receptor-alpha/beta+ cells: new clues to their origin, specificity, and function.

1995 • 355 citations

Cutting Edge: CpG Oligodeoxynucleotides Trigger Protective and Curative Th1 Responses in Lethal Murine Leishmaniasis

1998 • 349 citations

Tissue-Specific Segregation of CD1d-Dependent and CD1d-Independent NK T Cells

1999 • 332 citations

Immune suppression and skin cancer development: regulation by NKT cells

2000 • 327 citations

The role of different subsets of T regulatory cells in controlling autoimmunity

2000 • 323 citations

Bacterial CpG DNA Activates Immune Cells to Signal Infectious Danger

1999 • 315 citations

Bacterial DNA-Induced NK Cell IFN-γ Production Is Dependent on Macrophage Secretion of IL-12

1997 • 300 citations

Mouse NK1+ T cells

1995 • 292 citations

Peripheral Autoantigen Induces Regulatory T Cells that Prevent Autoimmunity

1999 • 284 citations

Immunostimulatory DNA: Sequence‐dependent production of potentially harmful or useful cytokines

1997 • 248 citations

Mouse NK1.1+ T cells: a new family of T cells

1996 • 236 citations

Rapid Death and Regeneration of NKT Cells in Anti-CD3ε- or IL-12-Treated Mice

1998 • 233 citations

CD1.1 Expression by Mouse Antigen-Presenting Cells and Marginal Zone B Cells

1998 • 230 citations

Mouse CD1 is mainly expressed on hemopoietic-derived cells.

1997 • 226 citations

Cytotoxic NK1.1 Ag+ alpha beta T cells with intermediate TCR induced in the liver of mice by IL-12.

1995 • 222 citations

Immunostimulatory Oligodeoxynucleotides Containing CpG Motifs Enhance the Efficacy of Monoclonal Antibody Therapy of Lymphoma

1997 • 208 citations

Diverse TCRs Recognize Murine CD1

1999 • 206 citations

Oligodeoxynucleotides containing CpG motifs can induce rejection of a neuroblastoma in mice.

1999 • 188 citations

Tissue-Specific Recognition of Mouse CD1 Molecules

1998 • 158 citations

In vivo persistence of expanded clones specific for bacterial antigens within the human T cell receptor alpha/beta CD4-8- subset.

1993 • 143 citations

Natural T cells. Cells that co-express NKRP-1 and TCR.

1995 • 111 citations

Essential requirement of an invariant V alpha 14 T cell antigen receptor expression in the development of natural killer T cells.

1996 • 101 citations

Tissue distribution, regulation and intracellular localization of murine CD1 molecules

1998 • 90 citations

Relative contribution of NK and NKT cells to the anti-metastatic activities of IL-12

2000 • 88 citations

APC Stimulated by CpG Oligodeoxynucleotide Enhance Activation of MHC Class I-Restricted T Cells

2000 • 81 citations

Evaluation of the Renal Effects of an Antisense Phosphorothioate Oligodeoxynucleotide in Monkeys

1999 • 73 citations

Direct thymic involvement in anterior chamber-associated immune deviation: evidence for a nondeletional mechanism of centrally induced tolerance to extrathymic antigens in adult mice.

1997 • 70 citations

Antimetastatic effect of CpG DNA mediated by type I IFN.

2001 • 64 citations

Induction of an Antigen-specific, CD1-restricted Cytotoxic T Lymphocyte Response In vivo

1998 • 57 citations

Use of CpG DNA for Enhancing Specific Immune Responses

2000 • 57 citations

The Murine Nonclassical Class I Major Histocompatibility Complex–like CD1.1 Molecule Protects Target Cells from Lymphokine-activated Killer Cell Cytolysis

1999 • 40 citations

Involvement of CD1 in Peripheral Deletion of T Lymphocytes Is Independent of NK T Cells

2001 • 16 citations

Comparative Contribution of CD1 on the Development of CD4+ and CD8+ T Cell Compartments

2000 • 13 citations

Cooperative effects of Mycobacterium tuberculosis Ag38 gene transduction and interleukin 12 in vaccination against spontaneous tumor development in proto-neu transgenic mice.

2000 • 9 citations

Conference on cancer vaccines

2000 • 2 citations

Deleted Work

1955 • 0 citations