Aging Results in Attenuated Gonadotropin Releasing Hormone-Luteinizing Hormone Axis Responsiveness to Glutamate Receptor Agonist N-Methyl-D-Aspartate*

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Mandatory Neuropeptide-Steroid Signaling for the Preovulatory Luteinizing Hormone-Releasing Hormone Discharge*

1993 • 390 citations

Excitatory amino acids and synaptic transmission: the evidence for a physiological function

1990 • 370 citations

Anatomic correlation of NMDA and 3H-TCP-labeled receptors in rat brain

1988 • 284 citations

Neuroendrocrine regulation of prolactin release

1989 • 282 citations

Puberty in monkeys is triggered by chemical stimulation of the hypothalamus.

1989 • 250 citations

Activation of Luteinizing Hormone-Releasing Hormone Release Advances the Onset of Female Puberty

1987 • 218 citations

Excitatory Amino Acids: Function and Significance in Reproduction and Neuroendocrine Regulation

1994 • 212 citations

Reproductive aging in the male brown-Norway rat: a model for the human.

1993 • 197 citations

Simultaneous Measurement of Luteinizing Hormone (LH)-Releasing Hormone, LH, and Follicle-Stimulating Hormone Release in Intact and Short-Term Castrate Rats*

1988 • 185 citations

Neuroendocrine Regulation of Pulsatile Luteinizing Hormone Release in the Rat

1980 • 159 citations

Changes with aging in the levels of amino acids in rat CNS structural elements I. Glutamate and related amino acids

1989 • 154 citations

Glutamate Receptors of the Non-N-Methyl-D-Aspartic Acid Type Mediate the Increase in Luteinizing Hormone-Releasing Hormone Release by Excitatory Amino Acidsin Vitro

1990 • 137 citations

Pulsatile Release of Gonadotropin-Releasing Hormone from Hypothalamic Explants Is Restrained by Blockade ofN-Methyl-<scp>D</scp>,<scp>L</scp>-Aspartate Receptors*

1989 • 108 citations

The Brown Norway Rat as a Model of Male Reproductive Aging: Evidence for Both Primary and Secondary Testicular Failure

1994 • 101 citations

Hypothalamic site of action for N-methyl-D-aspartate (NMDA) on LH secretion

1988 • 96 citations

DL-2-Amino-5-Phosphonopentanoic Acid, a Specific N-Methyl-&lt;i&gt;D&lt;/i&gt;-Aspartic Acid Receptor Antagonist, Suppresses Pulsatile LH Release in the Rat

1988 • 96 citations

Control of Pulsatile LH Release in Male Rats

1983 • 95 citations

Characterization and possible opioid modulation of N-methyl-D-aspartic acid induced increases in serum luteinizing hormone levels in the developing male rat

1988 • 88 citations

A new antiserum with conformational specificity for LHRH: Usefulness for radioimmunoassay and immunocytochemistry

1985 • 86 citations

Reproductive aging in the male brown-Norway rat: a model for the human

1993 • 82 citations

RAPID INCREASE IN LHRH mRNA LEVELS FOLLOWING NMDA

1991 • 81 citations

Endogenous excitatory amino acids and glutamate receptor subtypes involved in the control of hypothalamic luteinizing hormone-releasing hormone secretion.

1992 • 79 citations

N-Methyl-D-Aspartate Treatment Increases Circulating Adrenocorticotropin and Luteinizing Hormone in the Rat*

1991 • 76 citations

Evidence in support of nitric oxide (NO) involvement in the cyclic release of prolactin and LH surges

1994 • 76 citations

The Effects of Neurally Active Amino Acids on Pituitary Gonadotropin Secretion

1976 • 75 citations

Fasting-induced increases in food intake and neuropeptide Y gene expression are attenuated in aging male brown Norway rats.

1996 • 73 citations

Decreased gonadotropin-releasing hormone neurosecretory response to glutamate agonists in middle-aged female rats on proestrus afternoon: a possible role in reproductive aging?

1996 • 61 citations

Excitatory amino acid regulation of gonadotropin secretion: modulation by steroid hormones

1992 • 58 citations

Developmental Time Course of Pubertal and Photoperiodic Changes in Testosterone Negative Feedback on Gonadotropin Secretion in the Golden Hamster*

1983 • 55 citations

In the Male Brown‐Norway (BN) Male Rat, Reproductive Aging Is Associated With Decreased LH‐Pulse Amplitude and Area

1997 • 48 citations

Age-Related Decreases in Serum Gonadotropin Levels and Gonadotropin-Releasing Hormone Gene Expression in the Medial Preoptic Area of the Male Rat Are Dependent upon Testicular Feedback*

1991 • 48 citations

Endogenous excitatory amino acids and glutamate receptor subtypes involved in the control of hypothalamic luteinizing hormone-releasing hormone secretion

1992 • 45 citations

Dopamine‐Glutamate‐GABA Interactions and Ageing: Studies in the Striatum of the Conscious Rat

1995 • 44 citations

Excitatory amino acid neurotransmission evidence for a role in neuroendocrine regulation

1992 • 37 citations

Glutamate metabolism in ageing rat brain

1980 • 36 citations

Evidence that luteinizing hormone suppression in response to inhibitory neuropeptides, beta-endorphin, interleukin-1 beta, and neuropeptide-K, may involve excitatory amino acids.

1993 • 33 citations

Effect of NMDA and Non-NMDA Receptor Antagonists on Pulsatile Luteinizing Hormone Secretion in the Adult Male Rat

1995 • 32 citations

Gonadotropin Regulation in Middle-Aged Male Rats*

1980 • 31 citations

Fasting-induced increases in food intake and neuropeptide Y gene expression are attenuated in aging male brown Norway rats

1996 • 29 citations

Role of Excitatory Amino Acid Neurotransmission during Puberty in the Female Rat

1993 • 29 citations

Differential Gonadotropin Responses to N-Methyl-D,L-aspartate in Intact and Castrated Male Rats1

1993 • 28 citations

Decreased gonadotropin-releasing hormone neurosecretory response to glutamate agonists in middle-aged female rats on proestrus afternoon: a possible role in reproductive aging?

1996 • 23 citations

The Hypothalamic Peptides, β‐Endorphin, Neuropeptide K and Interleukin‐1β, and the Opiate Morphine, Enhance the Excitatory Amino Acid‐Induced LH Release under the Influence of Gonadal Steroids

1994 • 16 citations

Aging impairs galanin expression in luteinizing hormone-releasing hormone neurons: effect of ovariectomy and/or estradiol treatment.

1994 • 15 citations

Evidence that luteinizing hormone suppression in response to inhibitory neuropeptides, beta-endorphin, interleukin-1 beta, and neuropeptide-K, may involve excitatory amino acids

1993 • 10 citations

Aging impairs galanin expression in luteinizing hormone-releasing hormone neurons: effect of ovariectomy and/or estradiol treatment

1994 • 8 citations

Amino Acid Levels in the Hypothalamus and Response to N-Methyl-D-Aspartate and/or Dizocilpine Administration during Sexual Maturation in Female Rats

1993 • 7 citations

6 Interactions between brain peptides and sex steroids in the control of pituitary function

1985 • 4 citations