A Disulfide Bond between Conserved Extracellular Cysteines in the Thyrotropin-releasing Hormone Receptor Is Critical for Binding

STRUCTURE AND FUNCTION OF G PROTEIN-COUPLED RECEPTORS

1994 • 1,070 citations

Sequence Alignment of the G-Protein Coupled Receptor Superfamily

1992 • 847 citations

Cysteine residues 110 and 187 are essential for the formation of correct structure in bovine rhodopsin.

1988 • 409 citations

Structure and function of receptors coupled to G proteins

1994 • 377 citations

Structural features required for ligand binding to the beta-adrenergic receptor.

1987 • 358 citations

Cell Surface Receptors: A Short Course on Theory and Methods

1996 • 351 citations

Assembly of functional rhodopsin requires a disulfide bond between cysteine residues 110 and 187.

1990 • 320 citations

Cell Surface Receptors: A Short Course on Theory and Methods

1986 • 246 citations

Expression cloning of a cDNA encoding the mouse pituitary thyrotropin-releasing hormone receptor.

1990 • 225 citations

Role of extracellular disulfide-bonded cysteines in the ligand binding function of the .beta.2-adrenergic receptor

1990 • 215 citations

Role of the intradiscal domain in rhodopsin assembly and function.

1990 • 139 citations

Muscarinic acetylcholine receptors. Peptide sequencing identifies residues involved in antagonist binding and disulfide bond formation.

1990 • 138 citations

Identification of amino acid residues of rat angiotensin II receptor for ligand binding by site directed mutagenesis

1992 • 134 citations

Structure and function in rhodopsin: replacement by alanine of cysteine residues 110 and 187, components of a conserved disulfide bond in rhodopsin, affects the light-activated metarhodopsin II state.

1994 • 126 citations

Site-directed mutagenesis of the rat m1 muscarinic acetylcholine receptor. Role of conserved cysteines in receptor function.

1992 • 126 citations

The high affinity state of the beta 2-adrenergic receptor requires unique interaction between conserved and non-conserved extracellular loop cysteines.

1994 • 123 citations

Role of the extracellular regions of the parathyroid hormone (PTH)/PTH-related peptide receptor in hormone binding.

1994 • 113 citations

Visualization of the thyrotropin-releasing hormone receptor and its ligand during endocytosis and recycling.

1995 • 106 citations

Characteristics of thyrotropin releasing hormone (TRH) receptors in rat brain

1982 • 72 citations

Hydrogen bonding interaction of thyrotropin-releasing hormone (TRH) with transmembrane tyrosine 106 of the TRH receptor.

1994 • 58 citations

Role of cysteine residues in the extracellular domain and exoplasmic loops of the transmembrane domain of the TSH receptor: Effect of mutation to serine on TSH receptor activity and response to thyroid stimulating autoantibodies

1992 • 48 citations

A model of the thyrotropin-releasing hormone (TRH) receptor binding pocket. Evidence for a second direct interaction between transmembrane helix 3 and TRH.

1994 • 43 citations

Truncation of the Thyrotropin-releasing Hormone Receptor Carboxyl Tail Causes Constitutive Activity and Leads to Impaired Responsiveness in Xenopus Oocytes and AtT20 Cells

1995 • 43 citations

Sulfhydryl Groups in Receptor Binding of Thyrotropin‐Releasing Hormone to Rat Amygdala

1984 • 19 citations

Distinct roles for arginines in transmembrane helices 6 and 7 of the thyrotropin-releasing hormone receptor.

1995 • 19 citations

REGULATION OF THYROTROPIN-RELEASING HORMONE RECEPTORS IS CELL TYPE SPECIFIC: COMPARISON OF ENDOGENOUS PITUITARY RECEPTORS AND RECEPTORS TRANSFECTED INTO NON-PITUITARY CELLS

1991 • 13 citations

Point Mutations of the Thyrotropin Receptor Determining Structural Requirements for Its Ability to Bind Thyrotropin and to Stimulate Adenylate Cyclase Activity

1994 • 9 citations

The putative disulphide bond in muscarinic receptors

1990 • 5 citations