The hemK gene in Escherichia coli encodes the N5-glutamine methyltransferase that modifies peptide release factors

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

1986 • 6,284 citations

Fitting a mixture model by expectation maximization to discover motifs in biopolymers.

1994 • 4,818 citations

Predicting Subcellular Localization of Proteins Based on their N-terminal Amino Acid Sequence

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ACETYLORNITHINASE OF ESCHERICHIA COLI: PARTIAL PURIFICATION AND SOME PROPERTIES

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A short course in bacterial genetics

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Gene disruption in Escherichia coli: TcR and KmR cassettes with the option of Flp-catalyzed excision of the antibiotic-resistance determinant

1995 • 1,866 citations

Construction of versatile low-copy-number vectors for cloning, sequencing and gene expression in Escherichia coli

1991 • 1,170 citations

Tightly regulated tac promoter vectors useful for the expression of unfused and fused proteins in Escherichia coli

1988 • 1,049 citations

Genetic studies of the lac repressor

1977 • 500 citations

AdoMet-dependent methylation, DNA methyltransferases and base flipping

2001 • 475 citations

Structure-guided Analysis Reveals Nine Sequence Motifs Conserved among DNA Amino-methyl-transferases, and Suggests a Catalytic Mechanism for these Enzymes

1995 • 473 citations

The Crystal Structure of Human Eukaryotic Release Factor eRF1—Mechanism of Stop Codon Recognition and Peptidyl-tRNA Hydrolysis

2000 • 456 citations

DNA cloning by homologous recombination in Escherichia coli

2000 • 415 citations

Mutations in the highly conserved GGQ motif of class 1 polypeptide release factors abolish ability of human eRF1 to trigger peptidyl-tRNA hydrolysis

1999 • 352 citations

Automated construction and graphical presentation of protein blocks from unaligned sequences

1995 • 321 citations

Genetic studies of the lac repressor

1977 • 293 citations

A tripeptide ‘anticodon’ deciphers stop codons in messenger RNA

2000 • 285 citations

Translational termination comes of age

2000 • 202 citations

The accuracy of codon recognition by polypeptide release factors

2000 • 161 citations

A post-translational modification in the GGQ motif of RF2 from Escherichia coli stimulates termination of translation

2000 • 142 citations

Translation termination in eukaryotes: Polypeptide release factor eRF1 is composed of functionally and structurally distinct domains

2000 • 116 citations

Sequencing and analysis of bacterial genomes

1996 • 112 citations

Synthesis and degradation of termination and premature-termination fragments of β-galactosidase in vitro and in vivo

1978 • 88 citations

A mutational analysis of the two motifs common to adenine methyltransferases.

1994 • 82 citations

Release Factor-dependent False Stops are Infrequent in Escherichia coli

1993 • 79 citations

Functional specificity of amino acid at position 246 in the tRNA mimicry domain of bacterial release factor 2

1996 • 67 citations

Methylation of the ribosomal proteins in Escherichia coli. Nature and stoichiometry of the methylated amino acids in 50S ribosomal proteins

1975 • 66 citations

PATMAT: a searching and extraction program for sequence, pattern and block queries and databases

1992 • 64 citations

Identification and analysis of genes from Streptomyces pristinaespiralis encoding enzymes involved in the biosynthesis of the 4‐dimethylamino‐ <scp>l</scp> ‐phenylalanine precursor of pristinamycin I

1997 • 64 citations

Functional Roles of Conserved Amino Acid Residues in DNA Methyltransferases Investigated by Site-directed Mutagenesis of theEcoRV Adenine-N6-methyltransferase

1998 • 63 citations

A direct estimation of the context effect on the efficiency of termination

1998 • 58 citations

Shutdown in protein synthesis due to the expression of mini-genes in bacteria

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Genetics of ribosomal protein methylation in Escherichia coli

1977 • 53 citations

Cloning and sequencing of a previously unidentified gene that is involved in the biosynthesis of heme in Escherichia coli

1995 • 49 citations

Genetics of ribosomal protein methylation in Escherichia coli

1979 • 49 citations

Escherichia coli TehB Requires S -Adenosylmethionine as a Cofactor To Mediate Tellurite Resistance

2000 • 44 citations

Ribosomal protein methylation in Escherichia coli: the gene prmA, encoding the ribosomal protein L11 methyltransferase, is dispensable

1994 • 42 citations

Genetics of ribosomal protein methylation in Escherichia coli

1977 • 40 citations

Is the HemK Family of Putative S‐Adenosylmethionine‐Dependent Methyltransferases a “Missing” zeta Subfamily of Adenine Methyltransferases? A Hypothesis

1999 • 31 citations

Substitutions of the Glutamine Residue in the ubiquitous GGQ tripeptide in human eRF1 do not entirely abolish the release factor activity

2000 • 27 citations

The primary structure of ribosomal protein L3 from Escherichia coli 70 S ribosomes

1978 • 25 citations

[Mutation of a glutamine residue in the universal tripeptide GGQ in human eRF1 termination factor does not cause complete loss of its activity].

2000 • 25 citations

Structure-based sequence alignment of three AdoMet-dependent DNA methyltransferases

1995 • 23 citations

Functional analysis of thehemKgene product involvement in protoporphyrinogen oxidase activity in yeast

1999 • 17 citations

Translational Stop Signals: Evolution, Decoding for Protein Synthesis and Recoding for Alternative Events

1993 • 7 citations

Functional analysis of the hemK gene product involvement in protoporphyrinogen oxidase activity in yeast

1999 • 1 citations

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