Requirements for Localization of p130^cas to Focal Adhesions

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

1992 • 831 citations

Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin.

1992 • 811 citations

A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.

1994 • 653 citations

Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses

1983 • 518 citations

Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases.

1990 • 480 citations

Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas.

1995 • 423 citations

Induction of p130^cas Signaling Complex Formation upon Integrin-Mediated Cell Adhesion: a Role for Src Family Kinases

1996 • 422 citations

Cloning and Characterization of Cell Adhesion Kinase β, a Novel Protein-tyrosine Kinase of the Focal Adhesion Kinase Subfamily

1995 • 385 citations

Identification and Characterization of a Novel Related Adhesion Focal Tyrosine Kinase (RAFTK) from Megakaryocytes and Brain

1995 • 365 citations

p130Cas, a Substrate Associated with v-Src and v-Crk, Localizes to Focal Adhesions and Binds to Focal Adhesion Kinase

1996 • 364 citations

Integrin-mediated Cell Adhesion Promotes Tyrosine Phosphorylation of p130Cas, a Src Homology 3-containing Molecule Having Multiple Src Homology 2-binding Motifs

1995 • 340 citations

c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism.

1995 • 324 citations

Tyrosine Phosphorylation of p130Cas and Cortactin Accompanies Integrin-mediated Cell Adhesion to Extracellular Matrix

1995 • 289 citations

Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases

1995 • 288 citations

Direct Binding of the Proline-rich Region of Protein Tyrosine Phosphatase 1B to the Src Homology 3 Domain of p130Cas

1996 • 272 citations

Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527.

1994 • 253 citations

Cell spreading on extracellular matrix proteins induces tyrosine phosphorylation of tensin

1993 • 253 citations

Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinase

1989 • 239 citations

Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.

1996 • 235 citations

Human Enhancer of Filamentation 1, a Novel p130^cas-Like Docking Protein, Associates with Focal Adhesion Kinase and Induces Pseudohyphal Growth in Saccharomyces cerevisiae

1996 • 233 citations

Direct Binding of C-terminal Region of p130 to SH2 and SH3 Domains of Src Kinase

1996 • 229 citations

Adhesion-induced tyrosine phosphorylation of the p130 SRC substrate

1995 • 223 citations

Phosphotyrosine-containing proteins are concentrated in focal adhesions and intercellular junctions in normal cells.

1985 • 218 citations

Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes.

1996 • 165 citations

Src Kinase Plays an Essential Role in Integrin-Mediated Tyrosine Phosphorylation of Crk-Associated Substrate p130Cas

1996 • 124 citations

Overexpressed Csk Tyrosine Kinase Is Localized in Focal Adhesions, Causes Reorganization of α_vβ₅ Integrin, and Interferes with Hela Cell Spreading

1995 • 112 citations

Molecular cloning of a cDNA encoding a phosphoprotein, Efs, which contains a Src homology 3 domain and associates with Fyn.

1995 • 111 citations

The identification of p130cas-binding proteins and their role in cellular transformation.

1996 • 98 citations

Mutations in src homology regions 2 and 3 of activated chicken c-src that result in preferential transformation of mouse or chicken cells.

1990 • 93 citations

Characterization of the kinase activity essential for tyrosine phosphorylation of p130Cas in fibroblasts

1997 • 67 citations

An Examination of Focal Adhesion Formation and Tyrosine Phosphorylation in Fibroblasts Isolated from src¯, fyn¯, and yes¯ Mice

1995 • 59 citations

Detection of the v-abl gene product at cell-substratum contact sites in Abelson murine leukemia virus-transformed fibroblasts

1984 • 57 citations

Characterization, partial purification, and peptide sequencing of p130,the main phosphoprotein associated with v-Crk oncoprotein

1994 • 49 citations

Lymphocyte antigen receptor activation of a focal adhesion kinase-related tyrosine kinase substrate.

1994 • 47 citations

The C-terminal SH3 domain of the mouse c-Crk protein negatively regulates tyrosine-phosphorylation of Crk associated p130 in rat 3Y1 cells.

1994 • 40 citations

Fyn expression during early neurogenesis in mouse embryos.

1994 • 35 citations

Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein.

1993 • 28 citations