Predictors and rates of treatment-resistant tumor growth in acromegaly

Criteria for Cure of Acromegaly: A Consensus Statement

2000 • 1,013 citations

Treatment of Acromegaly with the Growth Hormone–Receptor Antagonist Pegvisomant

2000 • 856 citations

Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist

2001 • 637 citations

The outcome of surgery in 668 patients with acromegaly using current criteria of biochemical ‘cure’

2005 • 496 citations

Pituitary Disease in MEN Type 1 (MEN1): Data from the France-Belgium MEN1 Multicenter Study

2002 • 446 citations

The pathogenesis of pituitary tumours

2002 • 432 citations

Pituitary Tumor Transforming Gene (PTTG) Expression in Pituitary Adenomas

1999 • 406 citations

Cabergoline in the Treatment of Acromegaly: A Study in 64 Patients

1998 • 365 citations

Guidelines for Acromegaly Management

2002 • 354 citations

Transsphenoidal Microsurgery for Growth Hormone-Secreting Pituitary Adenomas: Initial Outcome and Long-Term Results

1998 • 347 citations

Surgical Management of GH-Secreting Pituitary Adenomas: An Outcome Study Using Modern Remission Criteria

2001 • 324 citations

Long‐term outcome and mortality after transsphenoidal adenomectomy for acromegaly

2003 • 308 citations

Outcome of transphenoidal surgery for acromegaly and its relationship to surgical experience

1999 • 294 citations

Somatostatin Analogs in Acromegaly

2002 • 283 citations

Primary Medical Therapy for Acromegaly: An Open, Prospective, Multicenter Study of the Effects of Subcutaneous and Intramuscular Slow-Release Octreotide on Growth Hormone, Insulin-Like Growth Factor-I, and Tumor Size

2002 • 280 citations

Angiogenesis in Endocrine Tumors

2003 • 276 citations

Octreotide Treatment of Acromegaly

1992 • 270 citations

The Antitumoral Effects of Somatostatin Analog Therapy in Acromegaly

2005 • 251 citations

Octreotide as Primary Therapy for Acromegaly

1998 • 243 citations

Treatment of Acromegaly with Dopamine Agonists

1992 • 222 citations

Bromocriptine treatment of acromegaly.

1975 • 198 citations

Pituitary Irradiation Is Ineffective in Normalizing Plasma Insulin-Like Growth Factor I in Patients with Acromegaly¹

1997 • 181 citations

Targeted expression of a human pituitary tumor–derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis

2002 • 178 citations

Long-term follow-up study of unruptured vertebral artery dissection: clinical outcomes and serial angiographic findings

2000 • 164 citations

Presurgical octreotide treatment in acromegaly

1992 • 148 citations

Effects of preoperative octreotide treatment on different subtypes of 90 GH-secreting pituitary adenomas and outcome in one surgical centre

2001 • 146 citations

Radiation Therapy of Acromegaly

1992 • 143 citations

Loss of Expression ofGADD45γ, a Growth Inhibitory Gene, in Human Pituitary Adenomas: Implications for Tumorigenesis

2002 • 139 citations

Transsphenoidal Surgery for Acromegaly in Wales: Results Based on Stringent Criteria of Remission

2003 • 135 citations

Growth pattern and rate in residual nonfunctioning pituitary adenomas: correlations among tumor volume doubling time, patient age, and MIB-1 index

2003 • 125 citations

A critical reappraisal of MIB-1 labelling index significance in a large series of pituitary tumours: secreting versus non-secreting adenomas.

2002 • 124 citations

Pronostic and Therapeutic Consequences of G_sα Mutations in Somatotroph Adenomas¹

1998 • 114 citations

Pituitary Tumor Transforming Gene (PTTG) Expression in Pituitary Adenomas

1999 • 111 citations

Use of cabergoline in the long-term treatment of hyperprolactinemic and acromegalic patients

1997 • 111 citations

In vivo responsiveness of morphological variants of growth hormone-producing pituitary adenomas to octreotide

1995 • 109 citations

Role of Matrix Metalloproteinase 9 in Pituitary Tumor Behavior

2000 • 101 citations

Pituitary Irradiation Is Ineffective in Normalizing Plasma Insulin-Like Growth Factor I in Patients with Acromegaly

1997 • 99 citations

Cabergoline in acromegaly: a renewed role for dopamine agonist treatment?

1998 • 99 citations

Pituitary Disease in MEN Type 1 (MEN1): Data from the France-Belgium MEN1 Multicenter Study

2002 • 99 citations

The sensitivity of growth hormone secretion to medical treatment in acromegalic patients: influence of age and sex

1992 • 98 citations

Control of Tumor Size and Disease Activity during Cotreatment with Octreotide and the Growth Hormone Receptor Antagonist Pegvisomant in an Acromegalic Patient

2001 • 98 citations

Transsphenoidal Microsurgery for Growth Hormone-Secreting Pituitary Adenomas: Initial Outcome and Long-Term Results

1998 • 96 citations

Optimizing Control of Acromegaly: Integrating a Growth Hormone Receptor Antagonist into the Treatment Algorithm

2003 • 94 citations

Long Term Effects of Continuous Subcutaneous Infusion of the Somatostatin Analog Octreotide in the Treatment of Acromegaly

1989 • 92 citations

Cabergoline in the Treatment of Acromegaly: A Study in 64 Patients

1998 • 86 citations

Failure of radiotherapy in acromegaly

2001 • 82 citations

Surgical Management of GH-Secreting Pituitary Adenomas: An Outcome Study Using Modern Remission Criteria

2001 • 80 citations

Effects of treatment with octreotide in acromegalic patients—a multicenter Italian study

1995 • 79 citations

Cytoplasmic Expression of Fibroblast Growth Factor Receptor-4 in Human Pituitary Adenomas: Relation to Tumor Type, Size, Proliferation, and Invasiveness

2004 • 78 citations

Clinical results of long‐term slow‐release lanreotide treatment of acromegaly

1997 • 68 citations

Effects of Octreotide Treatment on the Proliferation and Apoptotic Index of GH-Secreting Pituitary Adenomas

2001 • 67 citations

Somatostatin Analogs in Acromegaly

2002 • 66 citations

Sandostatin LAR in acromegalic patients: a dose-range study.

1995 • 66 citations

Expression analysis of cyclins in pituitary adenomas and the normal pituitary gland

2000 • 64 citations

Preoperative lanreotide treatment for GH‐secreting pituitary adenomas: effect on tumour volume and predictive factors of significant tumour shrinkage

2003 • 64 citations

Familial acromegaly: case report and review of the literature.

1999 • 60 citations

Morphological effects of octreotide on growth hormone-producing pituitary adenomas.

1994 • 58 citations

Long-term octreotide therapy in growth hormone-secreting pituitary adenomas: evaluation with serial MR.

1997 • 57 citations

Long-term treatment of acromegaly with the somatostatin analogue SR-lanreotide

1999 • 57 citations

Proliferation in Pituitary Adenomas: Measurement by MAb KI 67

1991 • 51 citations

Dopaminergic Treatment of Acromegaly: Different Effects on Hormone Secretion and Tumor Size *

1984 • 45 citations

Clinical and biochemical response following withdrawal of a long‐acting, depot injection form of octreotide (Sandostatin‐LAR^®)

1999 • 44 citations

Prognostic relevance of intracytoplasmic cytokeratin pattern, hormone expression profile, and cell proliferation in pituitary adenomas of akromegalic patients.

2001 • 40 citations

Pronostic and Therapeutic Consequences of Gs Mutations in Somatotroph Adenomas

1998 • 39 citations

Sandostatin LAR in acromegalic patients: a dose-range study

1995 • 38 citations

Control of Tumor Size and Disease Activity during Cotreatment with Octreotide and the Growth Hormone Receptor Antagonist Pegvisomant in an Acromegalic Patient

2001 • 36 citations

Loss of Expression of GADD45 , a Growth Inhibitory Gene, in Human Pituitary Adenomas: Implications for Tumorigenesis

2002 • 35 citations

Differences in Pathological Findings and Growth Hormone Responses in Patients with Growth Hormone-Producing Pituitary Adenoma.

1992 • 33 citations

FAMILIAL ACROMEGALY: STUDIES IN THREE FAMILIES

1990 • 32 citations

Reversible Shrinkage of a Growth Hormone-Secreting Pituitary Adenoma by a Long-Acting Somatostatin Analogue, Octreotide

1989 • 31 citations

Morphological effects of octreotide on growth hormone-producing pituitary adenomas

1994 • 27 citations

Role of Matrix Metalloproteinase 9 in Pituitary Tumor Behavior

2000 • 27 citations

Effects of Octreotide Treatment on the Proliferation and Apoptotic Index of GH-Secreting Pituitary Adenomas

2001 • 22 citations

Aggressive Pituitary Tumors in MEN1: Do They Refute the Two-Hit Model of Tumorigenesis?

2002 • 19 citations

Targeted expression of a human pituitary tumor–derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis

2002 • 17 citations

Cavernous Sinus Invasion and Tumor Proliferative Potential of Growth Hormone-Producing Pituitary Tumors

2000 • 16 citations

Medical Management of Acromegaly with Bromocriptine Effects of Continuous Treatment for Over Three Years

1978 • 14 citations

Aggressive Pituitary Tumors in MEN1: Do They Refute the Two-Hit Model of Tumorigenesis?

2002 • 8 citations

[Prognostic factors in the surgical management of acromegaly].

1999 • 7 citations

The Diagnosis and Treatment of Acromegaly

2003 • 3 citations