Glucose stimulates protein modification by O -linked GlcNAc in pancreatic β cells: Linkage of O -linked GlcNAc to β cell death

Reconstitution of I _KATP : An Inward Rectifier Subunit Plus the Sulfonylurea Receptor

1995 • 1,703 citations

Cloning of the β Cell High-Affinity Sulfonylurea Receptor: a Regulator of Insulin Secretion

1995 • 1,310 citations

Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1985 • 1,292 citations

Streptozotocin-Induced Pancreatic Insulitis: New Model of Diabetes Mellitus

1976 • 972 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

O-glycosylation of eukaryotic transcription factors: Implications for mechanisms of transcriptional regulation

1988 • 884 citations

A nutrient-sensing pathway regulates leptin gene expression in muscle and fat

1998 • 843 citations

Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and β-pancreatic islet cells

1988 • 786 citations

Glucose Toxicity

1990 • 742 citations

A Lesson in Metabolic Regulation Inspired by the Glucokinase Glucose Sensor Paradigm

1996 • 728 citations

Transcription from a TATA-less promoter requires a multisubunit TFIID complex.

1991 • 618 citations

Non-Insulin-Dependent Diabetes Mellitus — A Genetically Programmed Failure of the Beta Cell to Compensate for Insulin Resistance

1996 • 607 citations

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat.

1998 • 554 citations

Monoclonal antibodies identify a group of nuclear pore complex glycoproteins.

1987 • 533 citations

O-Linked GlcNAc Transferase Is a Conserved Nucleocytoplasmic Protein Containing Tetratricopeptide Repeats

1997 • 525 citations

DYNAMIC O-LINKED GLYCOSYLATION OF NUCLEAR AND CYTOSKELETAL PROTEINS

1997 • 502 citations

p53-dependent Induction of Apoptosis by Proteasome Inhibitors

1997 • 473 citations

Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes

1985 • 461 citations

STZ Transport and Cytotoxicity: Specific Enhancement in GLUT2-Expressing Cells

1994 • 429 citations

Reduced O Glycosylation of Sp1 Is Associated with Increased Proteasome Susceptibility

1997 • 429 citations

High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells.

1998 • 418 citations

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

1999 • 401 citations

Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin

1999 • 368 citations

Glucose and Tolbutamide Induce Apoptosis in Pancreatic β-Cells

1998 • 363 citations

Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes

1999 • 292 citations

Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions.

1986 • 287 citations

Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes

1999 • 286 citations

Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle.

1999 • 253 citations

Nitric Oxide Generation during Cellular Metabolization of the Diabetogenic N-Mefhyl-N-Nitroso-Urea Streptozotozin Contributes to Islet Cell DNA Damage

1995 • 227 citations

O Glycosylation of an Sp1-Derived Peptide Blocks Known Sp1 Protein Interactions

1997 • 222 citations

Structure of streptozotocin

1967 • 221 citations

Biochemical Evidence for Nitric Oxide Formation from Streptozotocin in Isolated Pancreatic Islets

1993 • 215 citations

Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus.

1996 • 203 citations

Discordance of Exocrine and Endocrine Growth After 90% Pancreatectomy in Rats

1988 • 178 citations

Streptozotocin Diabetes in the Mouse and Guinea Pig

1969 • 172 citations

Glucose Metabolism to Glucosamine Is Necessary for Glucose Stimulation of Transforming Growth Factor-α Gene Transcription

1996 • 168 citations

Genetic Influence of the Streptozotocin-induced Insulitis and Hyperglycemia

1977 • 153 citations

O-Linked N-Acetylglucosamine: The “Yin-Yang” of Ser/Thr Phosphorylation?

1995 • 136 citations

Elevated O-LinkedN-Acetylglucosamine Metabolism in Pancreatic β-Cells

1999 • 132 citations

Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase.

1992 • 128 citations

An N-terminal Region of Sp1 Targets Its Proteasome-dependent Degradation in Vitro

1999 • 109 citations

Poly(ADP-ribosyl)ation of p53 during apoptosis in human osteosarcoma cells.

1999 • 98 citations

Defective high-affinity thiamine transporter leads to cell death in thiamine-responsive megaloblastic anemia syndrome fibroblasts

1999 • 83 citations

Streptozotocin, an analog of N-acetylglucosamine, blocks the removal of O-GlcNAc from intracellular proteins.

1998 • 79 citations

Analysis of nuclear pore protein p62 glycosylation

1995 • 68 citations

Role of glucosamine synthesis in the stimulation of TGF-alpha gene transcription by glucose and EGF

1996 • 58 citations

Exposure of pancreatic islets to different alkylating agents decreases mitochondrial DNA content but only streptozotocin induces long-lasting functional impairment of B-cells

1991 • 37 citations

Partition of insulin-like growth factor (IGF)-binding sites between the IGF-I and IGF-II receptors and IGF-binding proteins in the human kidney.

1994 • 35 citations

Potentiation of Glucose-induced Insulin Release by Glucose in the Isolated Pancreas of Fed and Fasted Rats

1976 • 33 citations