Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

2003 • 10,537 citations

MAPMAKER: An interactive computer package for constructing primary genetic linkage maps of experimental and natural populations

1987 • 6,762 citations

Definition of Metabolic Syndrome

2004 • 5,872 citations

A Direct Approach to False Discovery Rates

2002 • 5,455 citations

Empirical threshold values for quantitative trait mapping.

1994 • 4,967 citations

Genome sequence of the Brown Norway rat yields insights into mammalian evolution

2004 • 2,149 citations

Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction

1992 • 1,956 citations

Accumulation of Dietary Cholesterol in Sitosterolemia Caused by Mutations in Adjacent ABC Transporters

2000 • 1,626 citations

Genetics of gene expression surveyed in maize, mouse and man

2003 • 1,518 citations

Genetic Dissection of Transcriptional Regulation in Budding Yeast

2002 • 1,389 citations

Genetic analysis of genome-wide variation in human gene expression

2004 • 1,219 citations

Genetical genomics: the added value from segregation

2001 • 1,014 citations

A Prospective Evaluation of an Angiotensin-Converting–Enzyme Gene Polymorphism and the Risk of Ischemic Heart Disease

1995 • 920 citations

Finding Genes That Underlie Complex Traits

2002 • 866 citations

Mouse genetics: concepts and applications

1995 • 791 citations

Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats

1999 • 739 citations

The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway

1999 • 732 citations

Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors

2003 • 639 citations

Natural variation in human gene expression assessed in lymphoblastoid cells

2003 • 561 citations

The nature and identification of quantitative trait loci: a community's view

2003 • 426 citations

Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma

2000 • 387 citations

Genetic Dissection of Complex Traits with Chromosome Substitution Strains of Mice

2004 • 349 citations

Rat genetics: attachign physiology and pharmacology to the genome

2002 • 271 citations

Genome-Wide Linkage Analyses of Systolic Blood Pressure Using Highly Discordant Siblings

1999 • 233 citations

Genome-Wide Linkage Analysis of Systolic and Diastolic Blood Pressure

2000 • 229 citations

Spontaneous Hypertension: Its Pathogenesis and Complications.

1973 • 212 citations

Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats

2001 • 202 citations

An analysis of spontaneous hypertension in spontaneously hypertensive rats by means of new recombinant inbred strains

1989 • 174 citations

Type I and type II error rates for quantitative trait loci (QTL) mapping studies using recombinant inbred mouse strains

1996 • 166 citations

Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains.

1995 • 162 citations

Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats

1997 • 147 citations

A genetic linkage map of the rat derived from recombinant inbred strains

1996 • 108 citations

Application of chromosomal substitution techniques in gene‐function discovery

2003 • 97 citations

Microarray Analysis of Rat Chromosome 2 Congenic Strains

2003 • 87 citations

Quantitative trait loci influencing cholesterol and phospholipid phenotypes map to chromosomes that contain genes regulating blood pressure in the spontaneously hypertensive rat.

1996 • 85 citations

Invited Review: HXB/BXH rat recombinant inbred strain platform: a newly enhanced tool for cardiovascular, behavioral, and developmental genetics and genomics

2003 • 72 citations

Insulin resistance in the conscious spontaneously hypertensive rat: Euglycemic hyperinsulinemic clamp study

1993 • 71 citations

Congenic Substitution Mapping Excludes Sa as a Candidate Gene Locus for a Blood Pressure Quantitative Trait Locus on Rat Chromosome 1

1999 • 62 citations

Genetic Dissection of Region Around the Sa Gene on Rat Chromosome 1

2001 • 62 citations

Spontaneous Hypertension

1972 • 61 citations

Successful Isolation of a Rat Chromosome 1 Blood Pressure Quantitative Trait Locus in Reciprocal Congenic Strains

1998 • 60 citations

Complete genome searches for quantitative trait loci controlling blood pressure and related traits in four segregating populations derived from Dahl hypertensive rats

1999 • 60 citations

Molecular basis of the Cd36 chromosomal deletion underlying SHR defects in insulin action and fatty acid metabolism

2002 • 58 citations

A SNP Map of the Rat Genome Generated from cDNA Sequences

2004 • 58 citations

Genetic analysis of “metabolic syndrome” in the spontaneously hypertensive rat

2004 • 52 citations

Novel Quantitative Trait Loci for Blood Pressure and Related Traits on Rat Chromosomes 1, 10, and 18

1997 • 40 citations

Insulin Resistance in Spontaneously Hypertensive Rats: Difference in Interpretation Based on Insulin Infusion Rate or on Plasma Insulin in Glucose Clamp Studies

1993 • 40 citations

A new framework marker-based linkage map and SDPs for the Rat HXB/BXH strain set

2003 • 20 citations

HXB/Ipcv and BXH/Cub recombinant inbred strains of the rat: strain distribution patterns of 632 alleles.

1999 • 18 citations

The rat comes clean

2004 • 8 citations

Genetic isolation of a quantitative trait locus on chromosome 18 associated with blood pressure and salt sensitivity in the SHR

2001 • 2 citations