The Requirement of Multimodal Therapy (Vaccine, Local Tumor Radiation, and Reduction of Suppressor Cells) to Eliminate Established Tumors

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

2001 • 1,609 citations

Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

2000 • 1,577 citations

Immunologic tolerance maintained by CD25⁺ CD4⁺ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

2001 • 1,515 citations

Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

1999 • 1,475 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer.

2001 • 1,126 citations

Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.

1999 • 1,066 citations

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

2001 • 1,033 citations

Cutting Edge: Control of CD8+ T Cell Activation by CD4+CD25+ Immunoregulatory Cells

2001 • 743 citations

Cutting Edge: Regulatory T Cells from Lung Cancer Patients Directly Inhibit Autologous T Cell Proliferation

2002 • 713 citations

Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell Receptors

2004 • 690 citations

Infectious Tolerance

2002 • 614 citations

Sublethal Irradiation of Human Tumor Cells Modulates Phenotype Resulting in Enhanced Killing by Cytotoxic T Lymphocytes

2004 • 532 citations

B cells and professional APCs recruit regulatory T cells via CCL4

2001 • 496 citations

Human CD4+CD25+ Regulatory, Contact-dependent T Cells Induce Interleukin 10–producing, Contact-independent Type 1-like Regulatory T Cells

2002 • 484 citations

Dendritic cells as a tool to induce anergic and regulatory T cells

2001 • 478 citations

CD4⁺CD25⁺ regulatory T cells in patients with gastrointestinal malignancies

2003 • 474 citations

Irradiation of Tumor Cells Up-Regulates Fas and Enhances CTL Lytic Activity and CTL Adoptive Immunotherapy

2003 • 452 citations

External Beam Radiation of Tumors Alters Phenotype of Tumor Cells to Render Them Susceptible to Vaccine-Mediated T-Cell Killing

2004 • 425 citations

Phase I Study of Sequential Vaccinations With Fowlpox-CEA(6D)-TRICOM Alone and Sequentially With Vaccinia-CEA(6D)-TRICOM, With and Without Granulocyte-Macrophage Colony-Stimulating Factor, in Patients With Carcinoembryonic Antigen–Expressing Carcinomas

2004 • 298 citations

A triad of costimulatory molecules synergize to amplify T-cell activation.

1999 • 293 citations

Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice.

2002 • 214 citations

Antitumor Activity and Immune Responses Induced by a Recombinant Carcinoembryonic Antigen-Vaccinia Virus Vaccine

1992 • 212 citations

Regulatory CD4+CD25+ T Cells Restrict Memory CD8+ T Cell Responses

2002 • 209 citations

TGF-β: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression

2003 • 207 citations

Depletion of CD4+CD25+ Regulatory Cells Augments the Generation of Specific Immune T Cells in Tumor-Draining Lymph Nodes

2002 • 206 citations

CD4+/CD25+ Regulatory Cells Inhibit Activation of Tumor-Primed CD4+ T Cells with IFN-γ-Dependent Antiangiogenic Activity, as well as Long-Lasting Tumor Immunity Elicited by Peptide Vaccination

2003 • 192 citations

Inhibition of cytolytic T lymphocyte proliferation by autologous CD4+/CD25+ regulatory T cells in a colorectal carcinoma patient is mediated by transforming growth factor-beta.

2002 • 186 citations

Induction of protective host immunity to carcinoembryonic antigen (CEA), a self-antigen in CEA transgenic mice, by immunizing with a recombinant vaccinia-CEA virus.

1999 • 181 citations

Transduction and expression of the human carcinoembryonic antigen gene in a murine colon carcinoma cell line.

1991 • 149 citations

Inhibition of human T cell proliferation by CTLA-4 utilizes CD80 and requires CD25+ regulatory T cells

2002 • 137 citations

Synergy of vaccine strategies to amplify antigen-specific immune responses and antitumor effects.

2001 • 137 citations

Mice transgenic for the human carcinoembryonic antigen gene maintain its spatiotemporal expression pattern.

1994 • 135 citations

RMA/S cells present endogenously synthesized cytosolic proteins to class I-restricted cytotoxic T lymphocytes.

1992 • 132 citations

Granulocyte/macrophage-colony stimulating factor produced by recombinant avian poxviruses enriches the regional lymph nodes with antigen-presenting cells and acts as an immunoadjuvant.

2001 • 126 citations

Vaccine-based therapy directed against carcinoembryonic antigen demonstrates antitumor activity on spontaneous intestinal tumors in the absence of autoimmunity.

2002 • 119 citations

Vector-based vaccine/cytokine combination therapy to enhance induction of immune responses to a self-antigen and antitumor activity.

2002 • 96 citations

MHC class I-restricted epitope spreading in the context of tumor rejection following vaccination with a single immunodominant CTL epitope

1999 • 86 citations

Complete regression of experimental solid tumors by combination LEC/chTNT-3 immunotherapy and CD25(+) T-cell depletion.

2003 • 65 citations

The Envelope Protein of an Endogenous Murine Retrovirus Is a Tumor-Associated T-Cell Antigen for Multiple Murine Tumors

2000 • 64 citations

Antitumor efficacy of wild-type p53-specific CD4(+) T-helper cells.

2002 • 57 citations

CD4+CD25+ T cells as immunoregulatory T cells in vitro

2002 • 55 citations

Immunoregulatory T cells in cancer immunotherapy

2002 • 55 citations

Identification of a Kb-restricted CTL Epitope of β-Galactosidase: Potential Use in Development of Immunization Protocols for “Self” Antigens

1997 • 54 citations

The use of combination vaccinia vaccines and dual-gene vaccinia vaccines to enhance antigen-specific T-cell immunity via T-cell costimulation

1999 • 44 citations

Characterization of CD8 + cytotoxic T lymphocyte/tumor cell interactions reflecting recognition of an endogenously expressed murine wild-type p53 determinant

2001 • 39 citations

Sequential Involvement of Two Distinct CD4⁺ Regulatory T Cells during the Course of Transplantable Tumor Growth and Protection from 3–Methylcholanthrene‐induced Tumorigenesis by CD25–depletion

2002 • 25 citations

Long-term treatment with low doses of interleukin-2 and interferon-α: immunological effects in advanced renal cell cancer

2001 • 22 citations

Significance of pre-treatment immunological parameters in colorectal cancer patients with unresectable metastases to the liver.

1999 • 21 citations

Serum Level of a Soluble Receptor for Interleukin-2 as a Prognostic Factor in Patients with Gastric Cancer

1999 • 21 citations

Serum soluble interleukin-2 receptor (IL-2R) and immunohistochemical staining of IL-2R/Tac antigen in colorectal cancer

2002 • 20 citations

Soluble Interleukin-2 Receptors in Patients with Advanced Colorectal Carcinoma

1996 • 4 citations

Deleted Work

1955 • 0 citations