Orbitofrontal Cortex and Its Contribution to Decision-Making

An Integrative Theory of Prefrontal Cortex Function

2001 • 11,688 citations

Descartes' Error: Emotion, Reason, and the Human Brain

1994 • 9,640 citations

The neural basis of drug craving: An incentive-sensitization theory of addiction

1993 • 7,074 citations

Choices, values, and frames.

1984 • 6,096 citations

Insensitivity to future consequences following damage to human prefrontal cortex

1994 • 5,933 citations

The Neural Basis of Decision Making

2007 • 3,662 citations

Neural systems of reinforcement for drug addiction: from actions to habits to compulsion

2005 • 3,624 citations

Deciding Advantageously Before Knowing the Advantageous Strategy

1997 • 3,454 citations

II.—WHAT IS AN EMOTION ?

1884 • 3,055 citations

Choices, Values, and Frames

2000 • 2,839 citations

Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex

1989 • 2,677 citations

The Psychology of Animal Learning

1976 • 2,451 citations

Descartes’ Error. Emotion, Reason and the Human Brain. New York (Grosset/Putnam) 1994.

1994 • 2,302 citations

What is an emotion

1977 • 2,254 citations

Discrete Coding of Reward Probability and Uncertainty by Dopamine Neurons

2003 • 2,034 citations

Abstract reward and punishment representations in the human orbitofrontal cortex

2001 • 2,023 citations

The psychology of animal learning

1975 • 1,995 citations

Different Contributions of the Human Amygdala and Ventromedial Prefrontal Cortex to Decision-Making

1999 • 1,980 citations

The Architecture of Cognitive Control in the Human Prefrontal Cortex

2003 • 1,802 citations

The James-Lange Theory of Emotions: A Critical Examination and an Alternative Theory

1927 • 1,736 citations

Neural correlates of decision variables in parietal cortex

1999 • 1,735 citations

Neurons in the orbitofrontal cortex encode economic value

2006 • 1,563 citations

Dissociation in prefrontal cortex of affective and attentional shifts

1996 • 1,527 citations

Addiction

2002 • 1,444 citations

Dissociation of Object and Spatial Processing Domains in Primate Prefrontal Cortex

1993 • 1,420 citations

Functional Imaging of Neural Responses to Expectancy and Experience of Monetary Gains and Losses

2001 • 1,419 citations

Severe disturbance of higher cognition after bilateral frontal lobe ablation

1985 • 1,407 citations

Relative reward preference in primate orbitofrontal cortex

1999 • 1,344 citations

Addiction and the brain: The neurobiology of compulsion and its persistence

2001 • 1,284 citations

Addiction, a Disease of Compulsion and Drive: Involvement of the Orbitofrontal Cortex

2000 • 1,224 citations

Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys

1995 • 1,216 citations

Handbook of neuropsychology

1993 • 1,166 citations

Encoding Predictive Reward Value in Human Amygdala and Orbitofrontal Cortex

2003 • 1,153 citations

The Neural Basis of Financial Risk Taking

2005 • 1,120 citations

A Role for Somatosensory Cortices in the Visual Recognition of Emotion as Revealed by Three-Dimensional Lesion Mapping

2000 • 1,065 citations

Dissociation Of Working Memory from Decision Making within the Human Prefrontal Cortex

1998 • 1,057 citations

Single neurons in prefrontal cortex encode abstract rules

2001 • 1,054 citations

Neural Economics and the Biological Substrates of Valuation

2002 • 1,012 citations

Emotion-related learning in patients with social and emotional changes associated with frontal lobe damage.

1994 • 1,010 citations

Distributed Neural Representation of Expected Value

2005 • 952 citations

The Anatomical Connections of the Macaque Monkey Orbitofrontal Cortex. A Review

2000 • 909 citations

Optimal decision making and the anterior cingulate cortex

2006 • 907 citations

Integration of What and Where in the Primate Prefrontal Cortex

1997 • 886 citations

An adaptive coding model of neural function in prefrontal cortex

2001 • 870 citations

Orbitofrontal cortex and basolateral amygdala encode expected outcomes during learning

1998 • 860 citations

The orbitofrontal cortex: Neuronal activity in the behaving monkey

1983 • 834 citations

Neuronal correlates of parametric working memory in the prefrontal cortex

1999 • 830 citations

Intra-Accumbens Amphetamine Increases the Conditioned Incentive Salience of Sucrose Reward: Enhancement of Reward “Wanting” without Enhanced “Liking” or Response Reinforcement

2000 • 760 citations

Neuroeconomics: The Consilience of Brain and Decision

2004 • 735 citations

Neural Signatures of Economic Preferences for Risk and Ambiguity

2006 • 704 citations

Reward expectancy in primate prefrental neurons

1996 • 694 citations

The Involvement of the Orbitofrontal Cortex in the Experience of Regret

2004 • 694 citations

Neural Activity in the Human Brain Relating to Uncertainty and Arousal during Anticipation

2001 • 684 citations

Sensory and premotor connections of the orbital and medial prefrontal cortex of macaque monkeys

1995 • 675 citations

Reward Timing in the Primary Visual Cortex

2006 • 657 citations

Architectonic subdivision of the orbital and medial prefrontal cortex in the macaque monkey

1994 • 656 citations

Cognitive Control Signals for Neural Prosthetics

2004 • 640 citations

Hedonic Hot Spot in Nucleus Accumbens Shell: Where Do μ-Opioids Cause Increased Hedonic Impact of Sweetness?

2005 • 637 citations

Cognitive Inflexibility After Prefrontal Serotonin Depletion

2004 • 629 citations

Neuronal activity in primate dorsolateral and orbital prefrontal cortex during performance of a reward preference task

2003 • 627 citations

Ventromedial frontal cortex mediates affective shifting in humans: evidence from a reversal learning paradigm

2003 • 615 citations

Different Underlying Impairments in Decision-making Following Ventromedial and Dorsolateral Frontal Lobe Damage in Humans

2004 • 605 citations

The orbital and medial prefrontal circuit through the primate basal ganglia

1995 • 602 citations

Neural Encoding in Orbitofrontal Cortex and Basolateral Amygdala during Olfactory Discrimination Learning

1999 • 602 citations

Bilateral Orbital Prefrontal Cortex Lesions in Rhesus Monkeys Disrupt Choices Guided by Both Reward Value and Reward Contingency

2004 • 585 citations

Separate neural pathways process different decision costs

2006 • 579 citations

Gustatory, olfactory, and visual convergence within the primate orbitofrontal cortex

1994 • 578 citations

Frontal Granular Cortex and Behavior.

1964 • 571 citations

Neuroeconomics: cross-currents in research on decision-making

2006 • 560 citations

Neuronal Activity Related to Reward Value and Motivation in Primate Frontal Cortex

2004 • 539 citations

A reexamination of the evidence for the somatic marker hypothesis: What participants really know in the Iowa gambling task

2004 • 538 citations

Prefrontal cortical projections to the hypothalamus in Macaque monkeys

1998 • 521 citations

Neural coding of basic reward terms of animal learning theory, game theory, microeconomics and behavioural ecology

2004 • 504 citations

Representations of Pleasant and Painful Touch in the Human Orbitofrontal and Cingulate Cortices

2003 • 504 citations

Interconnections between the prefrontal cortex and the premotor areas in the frontal lobe

1994 • 497 citations

Functional Specialization within Medial Frontal Cortex of the Anterior Cingulate for Evaluating Effort-Related Decisions

2003 • 491 citations

Hunger Modulates the Responses to Gustatory Stimuli of Single Neurons in the Caudolateral Orbitofrontal Cortex of the Macaque Monkey

1989 • 471 citations

Decisions, Uncertainty, and the Brain

2003 • 470 citations

Orbitofrontal cortex, decision-making and drug addiction

2006 • 463 citations

Auditory belt and parabelt projections to the prefrontal cortex in the Rhesus monkey

1999 • 462 citations

Effect of Expected Reward Magnitude on the Response of Neurons in the Dorsolateral Prefrontal Cortex of the Macaque

1999 • 458 citations

Specialized systems for the processing of mnemonic information within the primate frontal cortex

1996 • 442 citations

Decisions uncertainty. and the brain: The science of neuroeconomics

2003 • 432 citations

Emotional Responses to Pleasant and Unpleasant Olfactory, Visual, and Auditory Stimuli: a Positron Emission Tomography Study

2000 • 429 citations

Neuronal representations of cognitive state: reward or attention?

2004 • 404 citations

Different Roles for Orbitofrontal Cortex and Basolateral Amygdala in a Reinforcer Devaluation Task

2003 • 397 citations

The role of the prefrontal cortex in dynamic filtering

2000 • 377 citations

The Role of Rat Medial Frontal Cortex in Effort-Based Decision Making

2002 • 360 citations

Dissociable Contributions of the Human Amygdala and Orbitofrontal Cortex to Incentive Motivation and Goal Selection

2003 • 356 citations

Delay Activity of Orbital and Lateral Prefrontal Neurons of the Monkey Varying with Different Rewards

2000 • 348 citations

Cognitive Inflexibility after Prefrontal Serotonin Depletion Is Behaviorally and Neurochemically Specific

2006 • 344 citations

Reward Encoding in the Monkey Anterior Cingulate Cortex

2005 • 343 citations

Impact of Expected Reward on Neuronal Activity in Prefrontal Cortex, Frontal and Supplementary Eye Fields and Premotor Cortex

2003 • 304 citations

Weighing up the benefits of work: Behavioral and neural analyses of effort-related decision making

2006 • 303 citations

Efferent projections of infralimbic and prelimbic areas of the medial prefrontal cortex in the Japanese monkey, Macaca fuscata

2001 • 280 citations

Single cell activity in ventral prefrontal cortex of behaving monkeys

1981 • 236 citations

Influence of Reward Expectation on Visuospatial Processing in Macaque Lateral Prefrontal Cortex

2002 • 210 citations

The responsiveness of neurons in the insular gustatory cortex of the macaque monkey is independent of hunger

1988 • 206 citations

Resolution of Uncertainty in Prefrontal Cortex

2006 • 201 citations

Neural activity in the human brain relating to uncertainty and arousal during anticipation

2001 • 184 citations

Orbitofrontal sulci of the human and macaque monkey brain

2000 • 180 citations

Changes in Regional Cerebral Blood Flow Elicited by Craving Memories in Abstinent Opiate-Dependent Subjects

2001 • 161 citations

Orbitofrontal cortex and dynamic filtering of emotional stimuli

2002 • 159 citations

Neuronal Activity in Primate Orbitofrontal Cortex Reflects the Value of Time

2005 • 153 citations

The role of ventral and orbital prefrontal cortex in conditional visuomotor learning and strategy use in rhesus monkeys (Macaca mulatta).

2001 • 146 citations

The role of ventral and orbital prefrontal cortex in conditional visuomotor learning and strategy use in rhesus monkeys (Macaca mulatta).

2001 • 146 citations

Response Differences in Monkey TE and Perirhinal Cortex: Stimulus Association Related to Reward Schedules

2000 • 136 citations

Memory after frontal/temporal disconnection in monkeys: conditional and non-conditional tasks, unilateral and bilateral frontal lesions

1998 • 128 citations

Lesions of the orbitofrontal but not medial prefrontal cortex disrupt conditioned reinforcement in primates.

2003 • 124 citations

Lesions of the Orbitofrontal but not Medial Prefrontal Cortex Disrupt Conditioned Reinforcement in Primates

2003 • 112 citations

Social and motivational functioning is not critically dependent on feedback of autonomic responses: neuropsychological evidence from patients with pure autonomic failure

2004 • 94 citations

The emotions.

2005 • 59 citations

Contrasting Effects of Reward Expectation on Sensory and Motor Memories in Primate Prefrontal Neurons

2005 • 36 citations

Spatial and color working memory in patients with lateral prefrontal cortex lesions

2000 • 27 citations

Effects of intertrial interval and Trial 1 reward during acquisition of an object-discrimination learning set in monkeys.

1970 • 22 citations

Prefrontal cortical projections to the hypothalamus in Macaque monkeys

1998 • 21 citations