Orbitofrontal cortex, decision-making and drug addiction

The Emotional Brain

1996 • 3,578 citations

The Organization of Networks within the Orbital and Medial Prefrontal Cortex of Rats, Monkeys and Humans

2000 • 2,597 citations

The prefrontal cortex

1997 • 2,139 citations

Different Contributions of the Human Amygdala and Ventromedial Prefrontal Cortex to Decision-Making

1999 • 1,980 citations

PRELIMINARY ANALYSIS OF FUNCTIONS OF THE TEMPORAL LOBES IN MONKEYS

1939 • 1,703 citations

Dissociation in prefrontal cortex of affective and attentional shifts

1996 • 1,527 citations

The amygdala: Neurobiological aspects of emotion, memory, and mental dysfunction.

1992 • 1,517 citations

Relative reward preference in primate orbitofrontal cortex

1999 • 1,344 citations

Acute Effects of Cocaine on Human Brain Activity and Emotion

1997 • 1,263 citations

The cortical projections of the mediodorsal nucleus and adjacent thalamic nuclei in the rat

1977 • 1,259 citations

Addiction, a Disease of Compulsion and Drive: Involvement of the Orbitofrontal Cortex

2000 • 1,224 citations

The amygdala and reward

2002 • 1,156 citations

Decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in alcohol and stimulant abusers

2001 • 1,155 citations

Encoding Predictive Reward Value in Human Amygdala and Orbitofrontal Cortex

2003 • 1,153 citations

Dissociable Deficits in the Decision-Making Cognition of Chronic Amphetamine Abusers, Opiate Abusers, Patients with Focal Damage to Prefrontal Cortex, and Tryptophan-Depleted Normal Volunteers Evidence for Monoaminergic Mechanisms

1999 • 1,094 citations

Neural Responses during Anticipation of a Primary Taste Reward

2002 • 1,082 citations

Emotion-related learning in patients with social and emotional changes associated with frontal lobe damage.

1994 • 1,010 citations

The Amygdala: a functional analysis

2000 • 969 citations

Limbic lesions and the problem of stimulus—Reinforcement associations

1972 • 865 citations

Decision-making and addiction (part I): impaired activation of somatic states in substance dependent individuals when pondering decisions with negative future consequences

2002 • 862 citations

Functions of the frontal cortex of the rat: A comparative review

1984 • 862 citations

Orbitofrontal cortex and basolateral amygdala encode expected outcomes during learning

1998 • 860 citations

Organization of the projections from the subiculum to the ventral striatum in the rat. A study using anterograde transport of Phaseolus vulgaris leucoagglutinin

1987 • 857 citations

The prefrontal cortex of the rat. I. cortical projection of the mediodorsal nucleus. II. efferent connections

1969 • 845 citations

The orbitofrontal cortex: Neuronal activity in the behaving monkey

1983 • 834 citations

Behavioral changes associated with ablation of the amygdaloid complex in monkeys.

1956 • 818 citations

Projections from the amygdaloid complex to the cerebral cortex and thalamus in the rat and cat

1977 • 786 citations

Organization of the afferent connections of the mediodorsal thalamic nucleus in the rat, related to the mediodorsal-prefrontal topography

1988 • 729 citations

Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaine

1999 • 722 citations

Drug Seeking Becomes Compulsive After Prolonged Cocaine Self-Administration

2004 • 721 citations

The Involvement of the Orbitofrontal Cortex in the Experience of Regret

2004 • 694 citations

The primate mediodorsal (MD) nucleus and its projection to the frontal lobe

1985 • 652 citations

Do Rats Have Prefrontal Cortex? The Rose-Woolsey-Akert Program Reconsidered

1995 • 650 citations

Drug abusers show impaired performance in a laboratory test of decision making

2000 • 633 citations

Ventromedial frontal cortex mediates affective shifting in humans: evidence from a reversal learning paradigm

2003 • 615 citations

Amygdala circuitry in attentional and representational processes

1999 • 606 citations

Orbitofrontal Cortex and Representation of Incentive Value in Associative Learning

1999 • 606 citations

The orbital and medial prefrontal circuit through the primate basal ganglia

1995 • 602 citations

Neural Encoding in Orbitofrontal Cortex and Basolateral Amygdala during Olfactory Discrimination Learning

1999 • 602 citations

Control of Response Selection by Reinforcer Value Requires Interaction of Amygdala and Orbital Prefrontal Cortex

2000 • 588 citations

Bilateral Orbital Prefrontal Cortex Lesions in Rhesus Monkeys Disrupt Choices Guided by Both Reward Value and Reward Contingency

2004 • 585 citations

Decision-making and addiction (part II): myopia for the future or hypersensitivity to reward?

2002 • 585 citations

Dissociable Contributions of the Orbitofrontal and Infralimbic Cortex to Pavlovian Autoshaping and Discrimination Reversal Learning: Further Evidence for the Functional Heterogeneity of the Rodent Frontal Cortex

2003 • 548 citations

Neuronal Activity Related to Reward Value and Motivation in Primate Frontal Cortex

2004 • 539 citations

Impulsivity and rapid discounting of delayed hypothetical rewards in cocaine-dependent individuals.

2003 • 529 citations

Chapter 5 The anatomical relationship of the prefrontal cortex with the striatopallidal system, the thalamus and the amygdala: evidence for a parallel organization

1991 • 506 citations

Organization of the thalamo-cortical connexions to the frontal lobe in the rhesus monkey

1977 • 496 citations

Contemporary Learning Theories: Pavlovian Conditioning and the Status of Traditional Learning Theory

1991 • 484 citations

Impulsivity and rapid discounting of delayed hypothetical rewards in cocaine-dependent individuals.

2003 • 480 citations

Appetitive and Aversive Olfactory Learning in Humans Studied Using Event-Related Functional Magnetic Resonance Imaging

2002 • 479 citations

Encoding Predicted Outcome and Acquired Value in Orbitofrontal Cortex during Cue Sampling Depends upon Input from Basolateral Amygdala

2003 • 476 citations

Cortical, thalamic, and amygdaloid connections of the anterior and posterior insular cortices

1998 • 462 citations

Organization of amygdaloid projections to the prefrontal cortex and associated striatum in the rat

1991 • 456 citations

Functional Magnetic Resonance Imaging of Human Brain Activation During Cue-Induced Cocaine Craving

1998 • 442 citations

Incentive Sensitization by Previous Amphetamine Exposure: Increased Cue-Triggered “Wanting” for Sucrose Reward

2001 • 435 citations

The afferent input to the magnocellular division of the mediodorsal thalamic nucleus in the monkey, Macaca fascicularis

1987 • 414 citations

Different Roles for Orbitofrontal Cortex and Basolateral Amygdala in a Reinforcer Devaluation Task

2003 • 397 citations

The orbitofrontal cortex and its connections with the mediodorsal nucleus in rabbit, sheep and cat.

1948 • 363 citations

Orbitofrontal Cortex and Human Drug Abuse: Functional Imaging

2000 • 361 citations

Dissociable Contributions of the Human Amygdala and Orbitofrontal Cortex to Incentive Motivation and Goal Selection

2003 • 356 citations

Amygdaloid projections to the frontal cortex and the striatum in the rat

1990 • 348 citations

Information coding in the rodent prefrontal cortex. I. Single-neuron activity in orbitofrontal cortex compared with that in pyriform cortex

1995 • 332 citations

The organization of the thalamocortical connections of the mediodorsal thalamic nucleus in the rat, related to the ventral forebrain–prefrontal cortex topography

1992 • 328 citations

Lesions of Orbitofrontal Cortex and Basolateral Amygdala Complex Disrupt Acquisition of Odor-Guided Discriminations and Reversals

2003 • 304 citations

Experimental studies of commissural and reticular formation projections from the vestibular nuclei in the cat

1968 • 296 citations

Impairments of Reversal Learning and Response Perseveration after Repeated, Intermittent Cocaine Administrations to Monkeys

2002 • 274 citations

Preexposure sensitizes rats to the rewarding effects of cocaine

1990 • 273 citations

Orbitofrontal cortex is activated during breaches of expectation in tasks of visual attention

1999 • 257 citations

XI. An investigation into the functions of the occipital and temporal lobes of the monkey's brain

1888 • 255 citations

Substance use disorders and the orbitofrontal cortex

2005 • 225 citations

Rapid Associative Encoding in Basolateral Amygdala Depends on Connections with Orbitofrontal Cortex

2005 • 217 citations

Cocaine‐experienced rats exhibit learning deficits in a task sensitive to orbitofrontal cortex lesions

2004 • 193 citations

Opposite Effects of Amphetamine Self-administration Experience on Dendritic Spines in the Medial and Orbital Prefrontal Cortex

2004 • 179 citations

Oral cocaine seeking by rats: Action or habit?

2003 • 176 citations

Amygdalar interaction with the mediodorsal nucleus of the thalamus and the ventromedial prefrontal cortex in stimulus-reward associative learning in the monkey

1990 • 167 citations

Cajal on the Cerebral Cortex: An Annotated Translation of the Complete Writings

1989 • 166 citations

Orbital and Medial Prefrontal Cortex and Psychostimulant Abuse: Studies in Animal Models

2000 • 157 citations

Cocaine Makes Actions Insensitive to Outcomes but not Extinction: Implications for Altered Orbitofrontal–Amygdalar Function

2004 • 155 citations

Neuronal Activity in Primate Orbitofrontal Cortex Reflects the Value of Time

2005 • 153 citations

Enhanced responding for conditioned reward produced by intra-accumbens amphetamine is potentiated after cocaine sensitization

1999 • 143 citations

Information coding in the rodent prefrontal cortex. II. Ensemble activity in orbitofrontal cortex

1995 • 128 citations

Integrating Orbitofrontal Cortex into Prefrontal Theory: Common Processing Themes across Species and Subdivisions

2001 • 125 citations

Neural Correlates of Olfactory Recognition Memory in the Rat Orbitofrontal Cortex

2000 • 124 citations

Enhanced appetitive conditioning following repeated pretreatment with d-amphetamine

1998 • 107 citations

Repeated intermittent administration of psychomotor stimulant drugs alters the acquisition of Pavlovian approach behavior in rats: differential effects of cocaine, d-amphetamine and 3,4-methylenedioxymethamphetamine (“ecstasy”)

2001 • 107 citations

Crossmodal Associative Memory Representations in Rodent Orbitofrontal Cortex

1999 • 101 citations

Encoding Changes in Orbitofrontal Cortex in Reversal-Impaired Aged Rats

2005 • 81 citations

Ensemble coding in the nucleus accumbens

1999 • 60 citations

Blockade of sensitisation-induced facilitation of appetitive conditioning by post-session intra-amygdala nafadotride

2002 • 25 citations

Deleted Work

1955 • 0 citations