Serotonin neurotoxicity in rats after combined treatment with a dopaminergic agent followed by a nonneurotoxic 3,4-methylenedioxymethamphetamine (MDMA) analogue

Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity

1988 • 548 citations

Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine.

1987 • 526 citations

3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites.

1987 • 455 citations

Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain.

1987 • 451 citations

The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain

1986 • 354 citations

MDMA-induced neurotoxicity: Parameters of degeneration and recovery of brain serotonin neurons

1988 • 318 citations

Effects of enantiomers of MDA, MDMA and related analogues on [3H]serotonin and [3H]dopamine release from superfused rat brain slices

1986 • 312 citations

In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain

1987 • 301 citations

Amphetamine‐Induced Dopamine Release in the Rat Striatum: An In Vivo Microdialysis Study

1988 • 291 citations

Methylenedioxymethamphetamine: A potentially neurotoxic amphetamine analogue

1986 • 206 citations

Neurochemistry and Neurotoxicity of 3,4‐Methylenedioxymethamphetamine (MDMA, “Ecstasy”)

1990 • 189 citations

Immediate and long-term effects of 3,4-methylenedioxymethamphetamine on serotonin pathways in brain of rat

1987 • 186 citations

Role of endogenous dopamine in the central serotonergic deficits induced by 3,4-methylenedioxymethamphetamine.

1988 • 186 citations

Evidence for dual serotonergic projections to neocortex: Axons from the dorsal and median raphe nuclei are differentially vulnerable to the neurotoxin p-chloroamphetamine (PCA)

1988 • 183 citations

Stereochemical effects of 3,4-methylenedioxymethamphetamine (MDMA) and related amphetamine derivatives on inhibition of uptake of [3H]monoamines into synaptosomes from different regions of rat brain

1987 • 180 citations

Drug discrimination studies with MDMA and amphetamine

1988 • 148 citations

p -Chloroamphetamine: Selective Neurotoxic Action in Brain

1975 • 147 citations

Distinct morphologic classes of serotonergic axons in primates exhibit differential vulnerability to the psychotropic drug 3,4-methylenedioxymethamphetamine

1989 • 146 citations

Anatomic evidence for a neurotoxic effect of (±)-fenfluramine upon serotonergic projections in the rat

1990 • 121 citations

Characterization of [³H]Paroxetine Binding in Rat Brain

1988 • 121 citations

Serotonergic-dopaminergic mediation of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”)

1988 • 120 citations

In vivo monoamine oxidase inhibition by d-amphetamine

1980 • 117 citations

Ketanserin pretreatment attenuates MDMA-induced dopamine release in the striatum as measured by microdialysis

1990 • 114 citations

[3H]Monoamine releasing and uptake inhibition properties of 3,4-methylenedioxymethamphetaimne and p-chloroamphetamine analogues

1991 • 102 citations

Acute administration of methylenedioxymethamphetamine: comparison with the neurochemical effects of its N-desmethyl and N-ethyl analogs

1987 • 91 citations

Fenfluramine: evidence for a neurotoxic action on midbrain and a long-term depletion of serotonin.

1975 • 86 citations

Effects of methylenedioxymethamphetamine on the release of monoamines from rat brain slices

1990 • 86 citations

Antagonism of the neurotoxicity due to a single administration of methylenedioxymethamphetamine

1990 • 86 citations

Nonneurotoxic tetralin and indan analogs of 3,4-(methylenedioxy)amphetamine (MDA)

1990 • 84 citations

Long-term effects of fenfluramine on central serotonergic mechanisms

1979 • 78 citations

5-HT2 antagonists stereoselectively prevent the neurotoxicity of 3,4-methylenedioxymethamphetamine by blocking the acute stimulation of dopamine synthesis: reversal by L-dopa.

1991 • 78 citations

A comparison of the neurotoxic potential of methylenedioxyamphetamine (MDA) and its N-methylated and N-ethylated derivatives

1987 • 77 citations

Amphetamine derivatives induce locomotor hyperactivity by acting as indirect serotonin agonists

1991 • 73 citations

Selective 5-hydroxytryptamine2 receptor antagonists protect against the neurotoxicity of methylenedioxymethamphetamine in rats.

1990 • 61 citations

(+)-N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine as a discriminative stimulus in studies of 3,4-methylenedioxy-methamphetamine-like behavioral activity.

1990 • 53 citations

Synthesis and pharmacological examination of 1-(3-methoxy-4-methylphenyl)-2-aminopropane and 5-methoxy-6-methyl-2-aminoindan: similarities to 3,4-(methylenedioxy)methamphetamine (MDMA)

1991 • 53 citations

Comparative serotonin neurotoxicity of the stereoisomers of fenfluramine and norfenfluramine

1990 • 50 citations

MDMA as a discriminative stimulus: Isomeric comparisons

1987 • 48 citations

Role of the dopaminergic nigrostriatal pathway in methamphetamine-induced depression of the neostriatal serotonergic system

1987 • 44 citations

Long-term effects of 4-chloroamphetamine on brain 5-hydroxyindole metabolism in rats

1974 • 44 citations

Behavioral, biochemical and neurotoxicological actions of the α-ethyl homologue of p-chloroamphetamine

1990 • 37 citations

(±)3,4-Methylenedioxymethamphetamine (MDMA) produces long-term reductions in brain 5-hydroxytryptamine in rats

1987 • 37 citations

Effects of (±)3,4-methylenedioxymethamphetamine (MDMA) on brain dopaminergic activity in rats

1989 • 37 citations

Neurotoxic effects of the alpha-ethyl homologue of MDMA following subacute administration

1989 • 26 citations

Evaluation of the neurotoxic effects of p-chloroamphetamine: A histological and biochemical study

1978 • 26 citations

Combined administration of a non-neurotoxic 3,4-methylenedioxymethamphetamine analogue with amphetamine produces serotonin neurotoxicity in rats

1991 • 24 citations

Effect of (+)‐Amphetamine on the Retention of ³H‐Catecholamines in Slices of Normal and Reserpinized Rat Brain and Heart

1978 • 15 citations

Characterization of acute N-ethyl-3,4-methylenedioxyamphetamine (MDE) action on the central serotonergic system

1989 • 12 citations

Inhibition of 5-hydroxytryptamine accumulation and deamination by substituted phenylalkylamines in hypothalamic synaptosomes from normal and reserpine-pretreated rats

1987 • 9 citations

Release of 3H-5-hydroxytryptamine by amiflamine and related phenylalkylamines from rat occipital cortex slices

1989 • 8 citations