Neurochemistry and Neurotoxicity of 3,4‐Methylenedioxymethamphetamine (MDMA, “Ecstasy”)

Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity

1988 • 548 citations

Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine.

1987 • 526 citations

3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites.

1987 • 455 citations

Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain.

1987 • 451 citations

Long-term effects of multiple doses of methamphetamine on tryptophan hydroxylase and tyrosine hydroxylase activity in rat brain.

1980 • 444 citations

Subjective Reports of the Effects of MDMA in a Clinical Setting

1986 • 406 citations

Hallucinogenic Amphetamine Selectively Destroys Brain Serotonin Nerve Terminals

1985 • 371 citations

The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain

1986 • 354 citations

Serotonergic Neuronal Systems

1987 • 341 citations

MDMA-induced neurotoxicity: Parameters of degeneration and recovery of brain serotonin neurons

1988 • 318 citations

Effects of enantiomers of MDA, MDMA and related analogues on [3H]serotonin and [3H]dopamine release from superfused rat brain slices

1986 • 312 citations

In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain

1987 • 301 citations

Pharmacologic profile of MDMA (3,4-methylenedioxymethamphetamine) at various brain recognition sites

1988 • 299 citations

Role of dopamine in the neurotoxic effects of methamphetamine.

1985 • 299 citations

Toxic effects of MDMA on central serotonergic neurons in the primate: importance of route and frequency of drug administration

1988 • 255 citations

Demonstration and mapping of central neurons containing dopamine, noradrenaline, and 5-hydroxytryptamine and their reactions to psychopharmaca.

1966 • 239 citations

The Psychological and Physiological Effects of MDMA on Normal Volunteers

1986 • 232 citations

The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat

1988 • 224 citations

Methylenedioxymethamphetamine: A potentially neurotoxic amphetamine analogue

1986 • 206 citations

Long-term effects of p-chloroamphetamine and related drugs on central serotonergic mechanisms.

1975 • 200 citations

Immediate and long-term effects of 3,4-methylenedioxymethamphetamine on serotonin pathways in brain of rat

1987 • 186 citations

Role of endogenous dopamine in the central serotonergic deficits induced by 3,4-methylenedioxymethamphetamine.

1988 • 186 citations

Depression of rat brain tryptophan hydroxylase activity following the acute administration of methylenedioxymethamphetamine

1987 • 184 citations

Elevation of serum prolactin and corticosterone concentrations in the rat after the administration of 3,4-methylenedioxymethamphetamine.

1988 • 182 citations

Effects of certain hallucinogenic amphetamine analogs on the release of [3H]-serotonin from rat brain synaptosomes

1982 • 180 citations

Stereochemical effects of 3,4-methylenedioxymethamphetamine (MDMA) and related amphetamine derivatives on inhibition of uptake of [3H]monoamines into synaptosomes from different regions of rat brain

1987 • 180 citations

Distinct morphologic classes of serotonergic axons in primates exhibit differential vulnerability to the psychotropic drug 3,4-methylenedioxymethamphetamine

1989 • 146 citations

Differences in the central serotonergic effects of Methylenedioxymethamphetamine (MDMA) in mice and rats

1987 • 131 citations

Autoradiographic localization of ³H‐paroxetine‐labeled serotonin uptake sites in rat brain

1987 • 129 citations

FENFLURAMINE AND BRAIN SEROTONIN

1978 • 125 citations

Role of the dopamine uptake carrier in the neurochemical response to methamphetamine: Effects of amfonelic acid

1985 • 124 citations

3,4-Methylenedioxymethamphetamine (MDMA): Stereoselective interactions at brain 5-HT1 and 5-HT2 receptors

1986 • 119 citations

Neurochemical and neurohistological alterations in the rat and monkey produced by orally administered methylenedioxymethamphetamine (MDMA)

1988 • 110 citations

Reversible and irreversible phases of serotonin depletion by 4-chloroamphetamine

1975 • 109 citations

IMMEDIATE AND LONG‐TERM EFFECTS OF p‐CHLOROAMPHETAMINE ON BRAIN AMINES*

1978 • 106 citations

Long-term effects of methamphetamine on the synthesis and metabolism of 5-hydroxytryptamine in various regions of the rat brain

1981 • 96 citations

Acute administration of methylenedioxymethamphetamine: comparison with the neurochemical effects of its N-desmethyl and N-ethyl analogs

1987 • 91 citations

5-Hydroxyindoleacetic acid in cerebrospinal fluid reflects serotonergic damage induced by 3,4-methylenedioxymethamphetamine in CNS of non-human primates

1988 • 87 citations

A comparison of the neurotoxic potential of methylenedioxyamphetamine (MDA) and its N-methylated and N-ethylated derivatives

1987 • 77 citations

Further studies on the long-term depletion of striatal dopamine in iprindole-treated rats by amphetamine

1982 • 71 citations

Fenfluramine: neurotoxicity.

1986 • 68 citations

Effect of depletion of brain serotonin by repeated fenfluramine on neurochemical and anorectic effects of acute fenfluramine.

1988 • 64 citations

Effects of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine isomers on central serotonergic, dopaminergic and nigral neurotensin systems of the rat.

1988 • 61 citations

Orally administered MDMA causes a long-term depletion of serotonin in rat brain

1988 • 57 citations

Evidence for Distinct 5‐Hydroxytryptamine₂ Binding Site Subtypes in Cortical Membrane Preparations

1989 • 53 citations

3,4-Methylenedioxyethylamphetamine (MDE), a novel analogue of MDMA, produces long-lasting depletion of serotonin in the rat brain

1987 • 48 citations

The acute effects of methamphetamine, amphetamine and p-chloroamphetamine on the cortical serotonergic system of the rat brain: Evidence for differences in the effects of methamphetamine and amphetamine

1985 • 43 citations

(±)3,4-Methylenedioxymethamphetamine (MDMA) produces long-term reductions in brain 5-hydroxytryptamine in rats

1987 • 37 citations

Evidence for specific methylenedioxymethamphetamine (ecstasy) binding sites in the rat brain

1985 • 26 citations

Effects of N-ethyl-3,4-methylenedioxyamphetamine (MDE) on central serotonergic and dopaminergic systems of the rat

1987 • 20 citations

Ring-substituted amphetamine interactions with neurotransmitter receptor binding sites in human cortex

1988 • 17 citations

[3H]3,4-Methylenedioxymethamphetamine (MDMA) interactions with brain membranes and glass fiber filter paper

1987 • 16 citations

Effects of amphetamine analogs on neurotensin concentrations in rat brain

1987 • 15 citations

Effects of dopaminergic and serotonergic receptor blockade on neurochemical changes induced by acute administration of methamphetamine and 3,4-methylenedioxymethamphetamine

1988 • 14 citations

Reserpine does not prevent 3,4-methylenedioxymethamphetamine-induced neurotoxicity in the rat

1989 • 13 citations

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