The genetic basis of fluconazole resistance development in Candida albicans

Isogenic strain construction and gene mapping in Candida albicans.

1993 • 1,691 citations

Biofilm Formation by the Fungal Pathogen Candida albicans : Development, Architecture, and Drug Resistance

2001 • 1,503 citations

Clinical, Cellular, and Molecular Factors That Contribute to Antifungal Drug Resistance

1998 • 1,360 citations

Resistance of Candida species to fluconazole

1995 • 890 citations

Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters

1995 • 805 citations

Standardized Method for In Vitro Antifungal Susceptibility Testing of Candida albicans Biofilms

2001 • 695 citations

Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus

1997 • 608 citations

Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene

1997 • 578 citations

Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals

1995 • 476 citations

Prevalence of Molecular Mechanisms of Resistance to Azole Antifungal Agents in Candida albicans Strains Displaying High-Level Fluconazole Resistance Isolated from Human Immunodeficiency Virus-Infected Patients

2001 • 460 citations

Amino Acid Substitutions in the Cytochrome P-450 Lanosterol 14α-Demethylase (CYP51A1) from Azole-Resistant Candida albicans Clinical Isolates Contribute to Resistance to Azole Antifungal Agents

1998 • 451 citations

Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors

1996 • 407 citations

Resistance of Candida albicans biofilms to antifungal agents in vitro

1995 • 404 citations

Contribution of mutations in the cytochrome P450 14α-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans

1999 • 357 citations

Resistance to fluconazole and cross‐resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol Δ^5,6‐desaturation

1997 • 346 citations

Multiple Molecular Mechanisms Contribute to a Stepwise Development of Fluconazole Resistance in Clinical Candida albicans Strains

1998 • 336 citations

The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14alpha demethylase in Candida albicans

1997 • 291 citations

Multiple efflux mechanisms are involved in Candida albicans fluconazole resistance

1996 • 262 citations

Emergence of fluconazole-resistant strains of Candida albicans in patients with recurrent oropharyngeal candidosis and human immunodeficiency virus infection

1994 • 254 citations

The bZip Transcription Factor Cap1p Is Involved in Multidrug Resistance and Oxidative Stress Response in Candida albicans

1999 • 237 citations

Isolation and characterization of fluconazole- and amphotericin B-resistant Candida albicans from blood of two patients with leukemia

1997 • 227 citations

Fluconazole-resistant recurrent oral candidiasis in human immunodeficiency virus-positive patients: persistence of Candida albicans strains with the same genotype

1994 • 218 citations

Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate

1991 • 208 citations

Distinct Patterns of Gene Expression Associated with Development of Fluconazole Resistance in Serial Candida albicans Isolates from Human Immunodeficiency Virus-Infected Patients with Oropharyngeal Candidiasis

1998 • 206 citations

AP1-mediated Multidrug Resistance in Saccharomyces cerevisiae Requires FLR1 Encoding a Transporter of the Major Facilitator Superfamily

1997 • 204 citations

The Mutation T315A in Candida albicans Sterol 14α-Demethylase Causes Reduced Enzyme Activity and Fluconazole Resistance through Reduced Affinity

1997 • 200 citations

A novel multidrug efflux transporter gene of the major facilitator superfamily from Candida albicans (FLU1) conferring resistance to fluconazole

2000 • 194 citations

Diethylcarbamazine-related antimicrobial activity in Mycobacterium tuberculosis-infected blood

1998 • 183 citations

Targeted gene disruption in Candida albicans wild‐type strains: the role of the MDR1 gene in fluconazole resistance of clinical Candida albicans isolates

2000 • 150 citations

Candida albicans gene encoding resistance to benomyl and methotrexate is a multidrug resistance gene

1994 • 149 citations

Molecular analysis of cyp51 from fluconazole-resistant Candida albicans strains

2006 • 144 citations

Sequential gene disruption in Candida albicans by FLP‐mediated site‐specific recombination

1999 • 143 citations

Colonizing populations of Candida albicans are clonal in origin but undergo microevolution through C1 fragment reorganization as demonstrated by DNA fingerprinting and C1 sequencing

1995 • 142 citations

The R467K Amino Acid Substitution in Candida albicans Sterol 14α-Demethylase Causes Drug Resistance through Reduced Affinity

2000 • 132 citations

Molecular aspects of fluconazole resistance development in Candida albicans

1999 • 129 citations

Molecular analysis of cyp51 from fluconazole-resistant Candida albicans strains

1997 • 117 citations

The G464S Amino Acid Substitution in Candida albicans Sterol 14α-Demethylase Causes Fluconazole Resistance in the Clinic through Reduced Affinity

1999 • 116 citations

Divergence in Fitness and Evolution of Drug Resistance in Experimental Populations of Candida albicans

2001 • 115 citations

Y132H substitution inCandida albicanssterol 14α-demethylase confers fluconazole resistance by preventing binding to haem

1999 • 114 citations

Inducible Azole Resistance Associated with a Heterogeneous Phenotype in Candida albicans

2001 • 109 citations

Formation of Azole-Resistant Candida albicans by Mutation of Sterol 14-Demethylase P450

1999 • 101 citations

The Candida albicans CDR3 gene codes for an opaque-phase ABC transporter

1997 • 101 citations

Isolation of a Putative Candida albicans Transcriptional Regulator Involved in Pleiotropic Drug Resistance by Functional Complementation of a pdr1 pdr3 Mutation in Saccharomyces cerevisiae

1999 • 100 citations

Molecular genetic analysis of azole antifungal mode of action

1993 • 100 citations

The Lipid Composition of Azole-sensitive and Azole-resistant Strains of Candida albicans

1986 • 100 citations

Multiple Resistant Phenotypes of Candida albicans Coexist during Episodes of Oropharyngeal Candidiasis in Human Immunodeficiency Virus-Infected Patients

1999 • 97 citations

Multiple amino acid substitutions in lanosterol 14α-demethylase contribute to azole resistance in Candida albicans

1999 • 95 citations

Microbial fermentation-derived inhibitors of efflux-pump-mediated drug resistance

2001 • 94 citations

Multidrug resistance in Candida albicans: disruption of the BENr gene

1995 • 88 citations

MDR1 -Mediated Drug Resistance in Candida dubliniensis

2001 • 88 citations

Activation of the Multiple Drug Resistance Gene MDR1 in Fluconazole-Resistant, Clinical Candida albicans Strains Is Caused by Mutations in a trans -Regulatory Factor

2000 • 85 citations

Evolution and replacement of Candida albicans strains during recurrent vaginitis demonstrated by DNA fingerprinting

1994 • 81 citations

Genetic Analysis of Azole Resistance in the Darlington Strain of Candida albicans

2000 • 72 citations

Isolation, characterization, and sequencing of Candida albicans repetitive element 2

1992 • 71 citations

Changes of virulence factors accompanying the phenomenon of induced fluconazole resistance in Candida albicans

2000 • 66 citations

Asymmetric distribution of phosphatidylethanolamine inC. albicans : possible mediation byCDR1, a multidrug transporter belonging to ATP binding cassette (ABC) superfamily

1999 • 65 citations

A fourth gene from the Candida albicans CDR family of ABC transporters

1998 • 61 citations

Fluconazole versus Candida albicans : A Complex Relationship

1998 • 58 citations

Fluconazole susceptibility and strain variation of Candida albicans isolates from HIV-infected patients with oropharyngeal candidosis [published erratum appears in J Antimicrob Chemother 1998 Sep;42(3):413]

1998 • 38 citations

In Vitro and In Vivo Effects of 14α-Demethylase ( ERG11 ) Depletion in Candida glabrata

2001 • 35 citations

Isolation of Candida species on media with and without added fluconazole reveals high variability in relative growth susceptibility phenotypes

1997 • 29 citations

Decrease in Candida albicans strains with reduced susceptibility to fluconazole following changes in prescribing policies

2001 • 26 citations

Unusual Susceptibility of a Multidrug-Resistant Yeast Strain to Peptidic Antifungals

2001 • 20 citations