Recent advances in the genetics of schizophrenia

The American Journal of Human Genetics

1950 • 5,048 citations

Effect of COMT Val ^108/158 Met genotype on frontal lobe function and risk for schizophrenia

2001 • 2,408 citations

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

2003 • 1,925 citations

Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders

1996 • 1,780 citations

Neuregulin 1 and Susceptibility to Schizophrenia

2002 • 1,654 citations

Disruption of two novel genes by a translocation co-segregating with schizophrenia

2000 • 1,250 citations

Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia

2001 • 1,194 citations

Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part II: Schizophrenia

2003 • 1,160 citations

Kinetics of Human Soluble and Membrane-Bound Catechol O-Methyltransferase: A Revised Mechanism and Description of the Thermolabile Variant of the Enzyme

1995 • 1,152 citations

High Rates of Schizophrenia in Adults With Velo-Cardio-Facial Syndrome

1999 • 1,013 citations

Linkage strategies for genetically complex traits. II. The power of affected relative pairs.

1990 • 886 citations

Genetic Variation in the 6p22.3 Gene DTNBP1, the Human Ortholog of the Mouse Dysbindin Gene, Is Associated with Schizophrenia

2002 • 842 citations

Genetic and physiological data implicating the new human gene G72 and the gene for <scp>d</scp> -amino acid oxidase in schizophrenia

2002 • 828 citations

White Matter Changes in Schizophrenia

2003 • 794 citations

Schizophrenia and Affective Disorders—Cosegregation with a Translocation at Chromosome 1q42 That Directly Disrupts Brain-Expressed Genes: Clinical and P300 Findings in a Family

2001 • 729 citations

A Highly Significant Association between a COMT Haplotype and Schizophrenia

2002 • 701 citations

A Functional Polymorphism in the COMT Gene and Performance on a Test of Prefrontal Cognition

2002 • 613 citations

Genes for schizophrenia? Recent findings and their pathophysiological implications

2003 • 610 citations

Association of Neuregulin 1 with Schizophrenia Confirmed in a Scottish Population

2003 • 557 citations

Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21

1998 • 542 citations

Location of a Major Susceptibility Locus for Familial Schizophrenia on Chromosome 1q21-q22

2000 • 528 citations

Large Upward Bias in Estimation of Locus-Specific Effects from Genomewide Scans

2001 • 480 citations

A potential vulnerability locus for schizophrenia on chromosome 6p24–22: evidence for genetic heterogeneity

1995 • 465 citations

Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia

2001 • 448 citations

Psychotic Illness in Patients Diagnosed with Velo-Cardio-Facial Syndrome and Their Relatives

1994 • 434 citations

Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse

2001 • 393 citations

An international two–stage genome–wide search for schizophrenia susceptibility genes

1995 • 385 citations

Genomewide Genetic Linkage Analysis Confirms the Presence of Susceptibility Loci for Schizophrenia, on Chromosomes 1q32.2, 5q33.2, and 8p21-22 and Provides Support for Linkage to Schizophrenia, on Chromosomes 11q23.3-24 and 20q12.1-11.23

2001 • 376 citations

GGF/Neuregulin Is a Neuronal Signal That Promotes the Proliferation and Survival and Inhibits the Differentiation of Oligodendrocyte Progenitors

1996 • 374 citations

Association and linkage analyses of RGS4 polymorphisms in schizophrenia

2002 • 374 citations

Bipolar spectrum disorders in patients diagnosed with velo-cardio- facial syndrome: does a hemizygous deletion of chromosome 22q11 result in bipolar affective disorder?

1996 • 368 citations

Support for Association of Schizophrenia with Genetic Variation in the 6p22.3 Gene, Dysbindin, in Sib-Pair Families with Linkage and in an Additional Sample of Triad Families

2003 • 368 citations

A Haplotype Implicated in Schizophrenia Susceptibility Is Associated with Reduced COMT Expression in Human Brain

2003 • 340 citations

Genomic organization of the human catechol O‐methyltransferase gene and its expression from two distinct promoters

1994 • 332 citations

Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia

2002 • 322 citations

Dysbindin, a Novel Coiled-coil-containing Protein That Interacts with the Dystrobrevins in Muscle and Brain

2001 • 305 citations

The gene encoding proline dehydrogenase modulates sensorimotor gating in mice

1999 • 293 citations

A Genomewide Screen for Schizophrenia Genes in an Isolated Finnish Subpopulation, Suggesting Multiple Susceptibility Loci

1999 • 286 citations

Genome scan of European-American schizophrenia pedigrees: Results of the NIMH genetics initiative and millennium consortium

1998 • 278 citations

Polymorphisms at the G72/G30 Gene Locus, on 13q33, Are Associated with Bipolar Disorder in Two Independent Pedigree Series*

2003 • 270 citations

NIMH genetics initiative millennium schizophrenia consortium: Linkage analysis of African-American pedigrees

1998 • 269 citations

<scp>d</scp> -serine and serine racemase are present in the vertebrate retina and contribute to the physiological activation of NMDA receptors

2003 • 263 citations

Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene

1996 • 246 citations

A Genome-Wide Scan for Linkage to Chromosomal Regions in 382 Sibling Pairs With Schizophrenia or Schizoaffective Disorder

2002 • 244 citations

Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia

2003 • 239 citations

Cell death in the Schwann cell lineage and its regulation by neuregulin.

1996 • 237 citations

Cis-acting variation in the expression of a high proportion of genes in human brain

2003 • 234 citations

Suggestive Evidence for a Schizophrenia Susceptibility Locus on Chromosome 6q and a Confirmation in an Independent Series of Pedigrees

1997 • 234 citations

A combined analysis of D22S278 marker alleles in affected sib-pairs: Support for a susceptibility locus for schizophrenia at chromosome 22q12

1996 • 232 citations

Different Dystrophin-like Complexes Are Expressed in Neurons and Glia

1999 • 229 citations

Genome-wide scan for schizophrenia in the Finnish population: evidence for a locus on chromosome 7q22

2000 • 210 citations

Multicenter Linkage Study of Schizophrenia Candidate Regions on Chromosomes 5q, 6q, 10p, and 13q: Schizophrenia Linkage Collaborative Group III

2000 • 203 citations

D-Amino acid oxidase: new findings

2000 • 190 citations

Genetics of Schizophrenia and the New Millennium: Progress and Pitfalls

2001 • 184 citations

Additional support for schizophrenia linkage on chromosomes 6 and 8: A multicenter study

1996 • 184 citations

A genome-wide autosomal screen for schizophrenia susceptibility loci in 71 families with affected siblings: support for loci on chromosome 10p and 6

2000 • 172 citations

Genome-wide scan in a nationwide study sample of schizophrenia families in Finland reveals susceptibility loci on chromosomes 2q and 5q

2001 • 172 citations

Evidence suggestive of a locus on chromosome 5q31 contributing to susceptibility for schizophrenia in German and Israeli families by multipoint affected sib-pair linkage analysis

1997 • 157 citations

A Schizophrenia-Susceptibility Locus at 6q25, in One of the World's Largest Reported Pedigrees

2001 • 155 citations

Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part I: Methods and Power Analysis

2003 • 155 citations

Mice deleted for the DiGeorge/velocardiofacial syndrome region show abnormal sensorimotor gating and learning and memory impairments

2001 • 154 citations

No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol O-methyltransferase activity

1996 • 149 citations

Positive association between a DNA sequence variant in the serotonin 2A receptor gene and schizophrenia

1996 • 148 citations

Glial Growth Factor/Neuregulin Inhibits Schwann Cell Myelination and Induces Demyelination

2001 • 148 citations

Identification of a high-risk haplotype for the dystrobrevin binding protein 1 (DTNBP1) gene in the Irish study of high-density schizophrenia families.

2003 • 137 citations

Regional meta-analysis of published data supports linkage of autism with markers on chromosome 7

2002 • 130 citations

Is There Really A Split in Schizophrenia?

1987 • 128 citations

The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia

2002 • 128 citations

Preferential transmission of the high activity allele of COMT in schizophrenia

1996 • 127 citations

Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder

2001 • 127 citations

Chromosomal abnormalities and schizophrenia

2000 • 124 citations

Follow-up study on a susceptibility locus for schizophrenia on chromosome 6q

1999 • 107 citations

Genome scan of Arab Israeli families maps a schizophrenia susceptibility gene to chromosome 6q23 and supports a locus at chromosome 10q24

2003 • 106 citations

Chromosomal abnormalities and mental illness

2003 • 106 citations

Catechol-O-methyltransferase polymorphisms and schizophrenia

1997 • 106 citations

No evidence for association of the dysbindin gene [DTNBP1] with schizophrenia in an Irish population-based study

2003 • 97 citations

Characterization of Membrane‐Bound and Soluble Catechol‐O‐Methyltransferase from Human Frontal Cortex

1984 • 95 citations

Association study of a functional catechol-O-methyltransferase gene polymorphism in Japanese schizophrenics

1998 • 94 citations

Candidate-Gene Association Studies of Schizophrenia

1999 • 88 citations

Genome‐wide scan for linkage to schizophrenia in a Spanish‐origin cohort from Costa Rica

2002 • 87 citations

Association Analysis of a Functional Catechol-O-Methyltransferase Gene Polymorphism in Schizophrenic Patients in Taiwan

2001 • 79 citations

Soluble and Particulate Forms of Rat Catechol-O-Methyltransferase Distinguished by Gel Electrophoresis and Immune Fixation

1985 • 70 citations

Genomewide Multipoint Linkage Analysis of Seven Extended Palauan Pedigrees with Schizophrenia, by a Markov-Chain Monte Carlo Method

2001 • 67 citations

Searching for schizophrenia genes

2001 • 63 citations

Detailed analysis of PRODH and PsPRODH reveals no association with schizophrenia

2003 • 49 citations

A family-based association study of T1945C polymorphism in the proline dehydrogenase gene and schizophrenia in the Chinese population

2003 • 37 citations

Schizophrenia spectrum disorders: an autosomal-wide scan in multiplex pedigrees

2001 • 31 citations