Syncope, cerebral perfusion, and oxygenation

Handbook of Physiology.

1960 • 10,428 citations

Aviat space environ med

1992 • 7,493 citations

Cardiovascular System

2000 • 2,962 citations

Cerebral Blood Flow and Oxygen Consumption in Man

1959 • 1,965 citations

Cerebral autoregulation dynamics in humans.

1989 • 1,585 citations

On the local reactions of the arterial wall to changes of internal pressure

1902 • 1,485 citations

Computation of aortic flow from pressure in humans using a nonlinear, three-element model

1993 • 1,096 citations

Comparison of Static and Dynamic Cerebral Autoregulation Measurements

1995 • 863 citations

Transfer function analysis of dynamic cerebral autoregulation in humans

1998 • 845 citations

Transcranial Doppler measurement of middle cerebral artery blood flow velocity: a validation study.

1986 • 812 citations

Interpretation of near-infrared spectroscopy signals: a study with a newly developed perfused rat brain model

2001 • 807 citations

MRI Measures of Middle Cerebral Artery Diameter in Conscious Humans During Simulated Orthostasis

2000 • 718 citations

Compartmental analysis of compliance and outflow resistance of the cerebrospinal fluid system

1975 • 701 citations

Responses of cerebral arteries and arterioles to acute hypotension and hypertension

1978 • 691 citations

Cerebral Arterial Diameters during Changes in Blood Pressure and Carbon Dioxide during Craniotomy

1993 • 676 citations

Orthostatic Intolerance and Tachycardia Associated with Norepinephrine-Transporter Deficiency

2000 • 595 citations

A comparison of cardiac output derived from the arterial pressure wave against thermodilution in cardiac surgery patients †

2001 • 574 citations

Nitric oxide and the cerebral circulation.

1994 • 540 citations

Effect of alterations in the arterial carbon dioxide tension on the blood flow through the cerebral cortex at normal and low arterial blood pressures.

1965 • 515 citations

Assessment of cerebral pressure autoregulation in humans - a review of measurement methods

1998 • 497 citations

Comparison of flow and velocity during dynamic autoregulation testing in humans.

1994 • 471 citations

Syncope: A videometric analysis of 56 episodes of transient cerebral hypoxia

1994 • 445 citations

THE EFFECTS OF ACTIVE AND PASSIVE HYPERVENTILATION ON CEREBRAL BLOOD FLOW, CEREBRAL OXYGEN CONSUMPTION, CARDIAC OUTPUT, AND BLOOD PRESSURE OF NORMAL YOUNG MEN 1

1946 • 430 citations

Pancreatic Polypeptide: A Hormone Under Vagal Control

1983 • 422 citations

Phase Relationship Between Cerebral Blood Flow Velocity and Blood Pressure

1995 • 402 citations

Peripheral circulation and organ blood flow

1983 • 392 citations

Management of Vasovagal Syncope

2002 • 374 citations

Pressure-dependent membrane depolarization in cat middle cerebral artery.

1984 • 371 citations

Pathophysiological basis of orthostatic hypotension in autonomic failure

1999 • 370 citations

THE CEREBRAL BLOOD FLOW IN MALE SUBJECTS AS MEASURED BY THE NITROUS OXIDE TECHNIQUE. NORMAL VALUES FOR BLOOD FLOW, OXYGEN UTILIZATION, GLUCOSE UTILIZATION, AND PERIPHERAL RESISTANCE, WITH OBSERVATIONS ON THE EFFECT OF TILTING AND ANXIETY 1

1949 • 367 citations

Cerebral Autoregulation and Flow/Metabolism Coupling during Cardiopulmonary Bypass

1987 • 356 citations

Near-infrared oximetry of the brain

1999 • 325 citations

A simple mathematical model of the interaction between intracranial pressure and cerebral hemodynamics

1997 • 324 citations

The vasovagal response

1991 • 323 citations

COMPARISON OF THE FICK AND DYE INJECTION METHODS OF MEASURING THE CARDIAC OUTPUT IN MAN

1948 • 323 citations

Syncope

2000 • 306 citations

Continuous stroke volume monitoring by modelling flow from non-invasive measurement of arterial pressure in humans under orthostatic stress

1999 • 305 citations

Cerebral versus systemic hemodynamics during graded orthostatic stress in humans.

1994 • 302 citations

Transcranial Doppler is valid for determination of the lower limit of cerebral blood flow autoregulation.

1994 • 297 citations

DESCRIPTION OF THE MYOGENIC HYPOTHESIS.

1964 • 292 citations

Cerebral perfusion pressure, intracranial pressure, and head elevation

1986 • 289 citations

Observations on the Extrinsic Neural Control of Cerebral Blood Flow in the Baboon

1969 • 279 citations

Dynamic Regulation of Middle Cerebral Artery Blood Flow Velocity in Aging and Hypertension

2000 • 276 citations

Cerebral Blood Flow in Patients With Chronic Heart Failure Before and After Heart Transplantation

2001 • 276 citations

Evaluation of a Near-Infrared Spectrometer (NIRO 300) for the Detection of Intracranial Oxygenation Changes in the Adult Head

2001 • 273 citations

Autoregulation of Cerebral Blood Flow

1997 • 268 citations

Factors involved in the physiological regulation of the cerebral circulation

1984 • 261 citations

Dynamics of the cerebral blood flow response to step changes in end-tidal PCO2 and PO2 in humans

1996 • 260 citations

The value of the clinical history in the differentiation of syncope due to ventricular tachycardia, atrioventricular block, and neurocardiogenic syncope

1995 • 234 citations

Cerebral metabolic response to submaximal exercise

1999 • 232 citations

Chronic Orthostatic Intolerance

1998 • 228 citations

Carotid artery blood flow and middle cerebral artery blood flow velocity during physical exercise

1996 • 220 citations

Continuous Cardiac Output in Septic Shock by Simulating a Model of the Aortic Input Impedance

1999 • 215 citations

CEREBRAL CIRCULATION

1937 • 209 citations

Linear and nonlinear analysis of human dynamic cerebral autoregulation

1999 • 209 citations

Respiration‐synchronous fluctuations in stroke volume, heart rate and arterial pressure in humans.

1993 • 204 citations

Effect of CO₂on dynamic cerebral autoregulation measurement

1999 • 199 citations

Hypotension induced by passive head-up tilt: endocrine and circulatory mechanisms

1986 • 196 citations

Relationship between transcranial Doppler-determined pulsatility index and cerebrovascular resistance: an experimental study

1996 • 191 citations

Hypocapnia and Cerebral Hypoperfusion in Orthostatic Intolerance

1998 • 184 citations

Effects of hemorrhagic hypotension on the cerebral circulation. I. Cerebral blood flow and pial arteriolar caliber.

1979 • 178 citations

THE BLOOD FLOW IN THE BRAIN AND THE LEG OF MAN, AND THE CHANGES INDUCED BY ALTERATION OF BLOOD GASES 1

1932 • 174 citations

Initial blood pressure fall on stand up and exercise explained by changes in total peripheral resistance

1991 • 174 citations

ARTERIAL, CEREBROSPINAL AND VENOUS PRESSURES IN MAN DURING COUGH AND STRAIN

1944 • 171 citations

Experimental cerebral hemodynamics

1974 • 170 citations

Effects of the Valsalva Maneuver on Cerebral Circulation in Healthy Adults

1995 • 166 citations

Middle cerebral artery flow velocity and blood flow during exercise and muscle ischemia in humans

1992 • 161 citations

Frequency-domain analysis of cerebral autoregulation from spontaneous fluctuations in arterial blood pressure

1998 • 157 citations

Physical manoeuvres for combating orthostatic dizziness in autonomic failure

1992 • 156 citations

Effects of sympathetic nerves on cerebral vessels in dog, cat, and monkey

1978 • 154 citations

Interaction among autoregulation, CO₂ reactivity, and intracranial pressure: a mathematical model

1998 • 154 citations

Muscle Tensing During Standing

2001 • 150 citations

Deterioration of cerebral autoregulation during orthostatic stress: insights from the frequency domain

1998 • 150 citations

Middle cerebral artery blood velocity depends on cardiac output during exercise with a large muscle mass

1998 • 146 citations

Electroencephalographic brain mapping.

1991 • 139 citations

Vasovagal Syncope

2000 • 138 citations

Cerebral Oxygenation Declines in Healthy Elderly Subjects in Response to Assuming the Upright Position

2000 • 137 citations

Comparison between Near Infrared Spectroscopy and 133Xenon Clearance for Estimation of Cerebral Blood Flow in Critically Ill Preterm Infants

1993 • 132 citations

Training induced effects on blood volume, erythrocyte turnover and haemoglobin oxygen binding properties

1988 • 132 citations

Epidural Hydromorphone

1987 • 131 citations

The Mechanism of Syncope After Coughing

1953 • 129 citations

Cerebral Autoregulatory Responses to Head-Up Tilt in Normal Subjects and Patients With Recurrent Vasovagal Syncope

2001 • 127 citations

Effects of Leg Muscle Pumping and Tensing on Orthostatic Arterial Pressure: A Study in Normal Subjects and Patients with Autonomic Failure

1994 • 124 citations

Physiologic Principles for Volume Regulation of a Tissue Enclosed in a Rigid Shell with Application to the Injured Brain

1997 • 123 citations

Improvement of cardiac output estimation by the thermodilution method during mechanical ventilation

1986 • 122 citations

Finger Arterial versus Intrabrachial Pressure and Continuous Cardiac output during Head-up Tilt Testing in Healthy Subjects

1996 • 121 citations

Nervous control of the cerebrovascular system: doubts and facts

1999 • 120 citations

Middle cerebral artery blood velocity during exercise with β‐1 adrenergic and unilateral stellate ganglion blockade in humans

2000 • 120 citations

Dynamics of cerebral blood flow regulation explained using a lumped parameter model

2002 • 119 citations

The Effect of Hypocapnia on Arterial Blood Pressure

1954 • 119 citations

THE COLLAPSE FACTOR IN THE MEASUREMENT OF VENOUS PRESSURE

1941 • 119 citations

Nitric oxide mediates hypoxia-induced cerebral vasodilation in humans

2002 • 118 citations

Leg vasoconstriction during dynamic exercise with reduced cardiac output

1992 • 116 citations

Orthostatic Tolerance, Cerebral Oxygenation, and Blood Velocity in Humans With Sympathetic Failure

2000 • 113 citations

Cerebrovascular and Cardiovascular Measurements During Neurally Mediated Syncope Induced by Head-Up Tilt

1997 • 113 citations

Critical closure of pulmonary vessels analyzed in terms of Starling resistor model.

1968 • 110 citations

Middle cerebral artery blood velocity during a Valsalva maneuver in the standing position

2000 • 103 citations

H⁺ and pCO₂ as chemical factors in respiratory and cerebral circulatory control

1961 • 100 citations

Cerebrovascular Tone Rather Than Intracranial Pressure Determines the Effective Downstream Pressure of the Cerebral Circulation in the Absence of Intracranial Hypertension

2000 • 99 citations

Critical closing pressure in cerebrovascular circulation

1999 • 98 citations

Changes in cerebral blood flow estimated after stellate ganglion block by single photon emission computed tomography

1995 • 96 citations

Cervical and intracranial intra-arterial pressures with and without vascular occlusion.

1952 • 95 citations

Flow Velocity Measurements as an Index of Cerebral Blood Flow

1994 • 94 citations

Critical closing pressure explains cerebral hemodynamics during the Valsalva maneuver

1999 • 94 citations

Dynamic cerebral autoregulation is preserved in neurally mediated syncope

2001 • 93 citations

Critical Analysis of Cerebrovascular Autoregulation During Repeated Head-Up Tilt

2001 • 90 citations

Light-reflective cerebral oximetry and jugular bulb venous oxygen saturation during carotid endarterectomy

1994 • 89 citations

Scanning tunneling microscopy on rough surfaces-quantitative image analysis

1991 • 87 citations

Preservation of autoregulation of cerebral blood flow in autonomic failure

1980 • 84 citations

Transient Cerebral Circulatory Arrest Coincides With Fainting in Cough Syncope

1995 • 84 citations

Recognizing Syncope: Pitfalls and Surprises

1996 • 83 citations

Finapres arterial pulse wave analysis with Modelflow® is not a reliable non-invasive method for assessment of cardiac output

2002 • 79 citations

Cerebral Syncope: Loss of Consciousness Associated with Cerebral Vasoconstriction in the Absence of Systemic Hypotension

1998 • 79 citations

Relationship of ¹³³Xe Cerebral Blood Flow to Middle Cerebral Arterial Flow Velocity in Men at Rest

1996 • 77 citations

Effect of Pco ₂ Changes Induced by Head-Upright Tilt on Transcranial Doppler Recordings

1997 • 76 citations

Middle cerebral artery blood velocity during intense static exercise is dominated by a Valsalva maneuver

2003 • 75 citations

Cerebrovascular response to acute hypocapnic and eucapnic hypoxia in normal man

1970 • 74 citations

Neck and other muscle pains in autonomic failure: their association with orthostatic hypotension

1998 • 74 citations

Circulatory response evoked by a 3 s bout of dynamic leg exercise in humans.

1996 • 72 citations

Clinical characteristics of patients with vasovagal reactions presenting as unexplained syncope

2001 • 71 citations

Carbon dioxide, critical closing pressure and cerebral haemodynamics prior to vasovagal syncope in humans

2001 • 71 citations

Near‐infrared spectrophotometry determined brain oxygenation during fainting

1998 • 70 citations

Cerebral Vasoconstriction in Vasovagal Syncope: Any Link With Symptoms?

2001 • 70 citations

Validation of Transcranial Near-Infrared Spectroscopy for Evaluation of Cerebral Blood Flow Autoregulation

1996 • 69 citations

Increase in vagal activity during hypotensive lower-body negative pressure in humans

1988 • 69 citations

Syncope

1956 • 67 citations

The "Mess Trick" and the "Fainting Lark"

1951 • 65 citations

Cerebrovascular Regulation in the Postural Orthostatic Tachycardia Syndrome (POTS)

1999 • 65 citations

The Influence of the Force of Gravity on the Circulation

1897 • 64 citations

Middle cerebral artery blood velocity during exercise in patients with atrial fibrillation

1999 • 62 citations

Brain and muscle oxygen saturation during head‐up‐tilt‐induced central hypovolemia in humans

1995 • 62 citations

Cerebral and circulatory haemodynamics before vasovagal syncope induced by orthostatic stress

1997 • 62 citations

Middle cerebral artery velocity during head‐up tilt induced hypovolemic shock in humans

1993 • 61 citations

The Effect of Optode Positioning on Optical Pathlength in Near Infrared Spectroscopy of Brain

1990 • 56 citations

Cerebral Autoregulation in Orthostatic Intolerance

2001 • 55 citations

Mathematical considerations for modeling cerebral blood flow autoregulation to systemic arterial pressure

1998 • 54 citations

Human responses to emotional stress

1977 • 54 citations

Systemic circulatory responses to hypocapnia in man

1972 • 52 citations

Dynamics of Circulatory Adjustments to Head-Up Tilt and Tilt-Back in Healthy and Sympathetically Denervated Subjects

1998 • 50 citations

Neural Circulatory Control in Vasovagal Syncope

1997 • 50 citations

WEIGHT-LIFTERS' BLACKOUT

1973 • 50 citations

Middle cerebral artery blood flow velocity in elite power athletes during maximal weight-lifting

2000 • 49 citations

Cerebral blood flow velocity declines before arterial pressure in patients with orthostatic vasovagal presyncope

2002 • 48 citations

AN EMOTIONAL FAINT

1951 • 47 citations

Failure of hemoconcentration during standing to reveal plasma volume decline induced in the erect posture

1994 • 45 citations

Vasodepressor syncope

1959 • 45 citations

Effect of muscle tension on the cardiovascular responses to lower body negative pressure in man

1987 • 44 citations

Critical limits of pressure-flow relation in the human brain.

1992 • 43 citations

Influence of hydrostatic pressure gradients on regulation of plasma volume after exercise

1998 • 41 citations

Reflex vascular defects in the orthostatic tachycardia syndrome of adolescents

2001 • 41 citations

The eye movements of syncope

1996 • 41 citations

Twenty‐four‐hour non‐invasive monitoring of systemic haemodynamics and cerebral blood flow velocity in healthy humans

2002 • 41 citations

Interactions between CO₂chemoreflexes and arterial baroreflexes

1998 • 40 citations

Direct Vasodilator Effect of Hyperventilation-Induced Hypocarbia in Autonomic Failure Patients

1991 • 40 citations

Part 1. The initial evaluation of patients with syncope

2001 • 40 citations

Effects of positive end-expiratory pressure ventilation on cerebral venous pressure with head elevation in dogs

2000 • 39 citations

The Effect of Walking on the Venous Pressure at the Ankle¹

1936 • 38 citations

Tolerance to head-up tilt and suspension with elevated legs.

1998 • 38 citations

Assessment of Critical Closing Pressure in the Cerebral Circulation as a Measure of Cerebrovascular Tone

1999 • 36 citations

Modeling cerebral autoregulation and CO₂ reactivity in patients with severe head injury

1998 • 35 citations

Syncope induced by the Valsalva maneuver

1964 • 34 citations

Inspiratory CO2 increases orthostatic tolerance during repeated tilt.

2001 • 34 citations

In-flight cerebral oxygen status: continuous monitoring by near-infrared spectroscopy.

2000 • 31 citations

Some physiological observations on French horn musicians.

1975 • 31 citations

Differences in circulatory control in normal subjects who faint and who do not faint during orthostatic stress

1993 • 31 citations

Cerebral Blood Flow Velocities and Trigeminal Ganglion Stimulation

1996 • 30 citations

The role of arterial and venous pressure for volume regulation of an organ enclosed in a rigid compartment with application to the injured brain

1999 • 30 citations

An indifference point for electrical impedance in humans

1993 • 28 citations

Cerebral blood flow velocities during orthostasis and physical exercise

1991 • 27 citations

The Transactions of The Medico-Chirurgical Society of Edinburgh

1883 • 25 citations

Effect of pH changes on reactivity of rat mesenteric artery segments at different magnitude of stretch

2002 • 21 citations

Cerebral Blood Flow and Metabolism during Cardiopulmonary Bypass with Special Reference to Effects of Hypotension Induced by Prostacyclin

1986 • 20 citations

The fainting lark

2002 • 20 citations

Cerebrovascular Regulation in the Postural Orthostatic Tachycardia Syndrome (POTS)

1999 • 19 citations

Visual symptoms and G-LOC in the operational environment and during centrifuge training of Turkish jet pilots.

1999 • 18 citations

Modulation of myogenic responsiveness by CO2 in rat diaphragmatic arterioles: role of the endothelium

1997 • 17 citations

Local vascular responses to elevation of an organ above the heart

1996 • 17 citations

Operational G-induced loss of consciousness: something old; something new.

1985 • 16 citations

Vasovagal syncope: prevalence and presentation. An algorithm of management in the aviation environment.

1999 • 14 citations

Arterial diameter during central volume depletion in humans

1995 • 12 citations

Cerebrovascular and cardiovascular responses associated with orthostatic intolerance and tachycardia

2001 • 12 citations

Cerebral hemodynamics in carotid sinus syndrome and atrioventricular block

2000 • 11 citations

Differences in the dynamic cerebrovascular response between stepwise up tilt and down tilt in humans

2001 • 9 citations

Valsalva-induced syncope during apnea diving

2000 • 9 citations

Effect of Optode Separation on Brain Penetration in Adults

1996 • 7 citations

Reduction of Carotid Artery Blood Flow in Pediatric Patients with Syncope: Evaluation with Head-Up Tilt Test

2001 • 5 citations

The opticogravic nerve: eye-level anatomic relationships within the central nervous system.

1993 • 5 citations

Control for Carbon DioxideRelated Changes in Flow Velocity by Transcranial Doppler Monitoring

1994 • 3 citations

Deleted Work

1955 • 0 citations