Impaired Activation of Islet-Reactive CD4 T Cells in Pancreatic Lymph Nodes of B Cell-Deficient Nonobese Diabetic Mice

Antigen-specific interaction between T and B cells

1985 • 1,396 citations

Following a diabetogenic T cell from genesis through pathogenesis

1993 • 708 citations

The Nonobese Diabetic Mouse as a Model of Autoimmune Diabetes: Immune Dysregulation Gets the NOD

1997 • 685 citations

B cells acquire antigen from target cells after synapse formation

2001 • 606 citations

B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice.

1996 • 581 citations

Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response.

1997 • 489 citations

B Lymphocytes Are Critical Antigen-Presenting Cells for the Initiation of T Cell-Mediated Autoimmune Diabetes in Nonobese Diabetic Mice

1998 • 454 citations

Initiation of Autoimmune Diabetes by Developmentally Regulated Presentation of Islet Cell Antigens in the Pancreatic Lymph Nodes

1999 • 426 citations

T cell priming in vivo: a major role for B cells in presenting antigen to T cells in lymph nodes.

1987 • 286 citations

B Lymphocytes Are Crucial Antigen-Presenting Cells in the Pathogenic Autoimmune Response to GAD65 Antigen in Nonobese Diabetic Mice

1998 • 259 citations

B-Cells Are Required for the Initiation of Insulitis and Sialitis in Nonobese Diabetic Mice

1997 • 254 citations

I-Ag7-mediated antigen presentation by B lymphocytes is critical in overcoming a checkpoint in T cell tolerance to islet beta cells of nonobese diabetic mice.

1999 • 228 citations

Prevention of diabetes in nonobese diabetic mice by dendritic cell transfer.

1992 • 224 citations

Promotion of spontaneous diabetes in non-obese diabetes-prone mice by cyclophosphamide

1984 • 220 citations

B Lymphocytes as Antigen-Presenting Cells for CD4+ T Cell Priming In Vivo

1999 • 207 citations

The role of antigen-presenting B cells in T cell priming in vivo. Studies of B cell-deficient mice.

1988 • 199 citations

Anti‐suppressor effect of cyclophosphamide on the development of spontaneous diabetes in nod mice

1988 • 199 citations

I-Ag7-Mediated Antigen Presentation by B Lymphocytes Is Critical in Overcoming a Checkpoint in T Cell Tolerance to Islet β Cells of Nonobese Diabetic Mice

1999 • 190 citations

Direct evidence for the contribution of B cells to the progression of insulitis and the development of diabetes in non-obese diabetic mice

1997 • 178 citations

Evidence for an Underlying CD4 Helper and CD8 T-Cell Defect in B-Cell-Deficient Mice: Failure To Clear Persistent Virus Infection after Adoptive Immunotherapy with Virus-Specific Memory Cells from μMT/μMT Mice

1998 • 163 citations

Cyclophosphamide-Induced Diabetes in NOD/WEHI Mice: Evidence for Suppression in Spontaneous Autoimmune Diabetes Mellitus

1989 • 122 citations

Ontogeny of T cell tolerance to peripherally expressed antigens

1999 • 107 citations

B-cells are required for the initiation of insulitis and sialitis in nonobese diabetic mice

1997 • 101 citations

In vivo activation of naive T cells by antigen-presenting B cells.

1994 • 95 citations

Resting B Lymphocytes as APC for Naive T Lymphocytes: Dependence on CD40 Ligand/CD40

2000 • 89 citations

Introduction

1997 • 87 citations

Cellular and molecular changes accompanying the progression from insulitis to diabetes

1999 • 85 citations

Development of Insulitis and Diabetes in B Cell-Deficient NOD Mice

1997 • 81 citations

Impaired CD4 T Cell Activation Due to Reliance Upon B Cell-Mediated Costimulation in Nonobese Diabetic (NOD) Mice

2000 • 64 citations

Cyclophosphamide-induced diabetes in NOD/WEHI mice. Evidence for suppression in spontaneous autoimmune diabetes mellitus

1989 • 52 citations

Development and Function of Diabetogenic T-cells in B-cell–Deficient Nonobese Diabetic Mice

2001 • 46 citations

Pancreatic Lymph Nodes are Early Targets of T Cells during Adoptive Transfer of Diabetes in NOD Mice

1995 • 36 citations

A DIRECT METHOD FOR THE CALCULATION OF ALLOREACTIVE CD4+ T CELL PRECURSOR FREQUENCY1

1999 • 36 citations

Antigen presentation by hapten-specific B lymphocytes. IV. Comparative ability of B cells to present specific antigen and anti-immunoglobulin antibody.

1987 • 27 citations

The Effect of Cyclophosphamide Treatment on Lymphocyte Subsets in the Nonobese Diabetic Mouse: A Comparison of Various Lymphoid organs

1993 • 23 citations

Characterization of Distinct Islet Protein Auto Antigens Associated with Type 1 Diabetes

1993 • 13 citations

Lymph Node T-Cells Do Not Optimally Transfer Diabetes in NOD Mice

1993 • 12 citations

Lymph node T-cells do not optimally transfer diabetes in NOD mice

1993 • 6 citations