Monotherapy or Polytherapy for Epilepsy?

Comparison of Carbamazepine, Phenobarbital, Phenytoin, and Primidone in Partial and Secondarily Generalized Tonic–Clonic Seizures

1985 • 1,149 citations

A Comparison of Valproate with Carbamazepine for the Treatment of Complex Partial Seizures and Secondarily Generalized Tonic–Clonic Seizures in Adults

1992 • 685 citations

Double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy

1995 • 627 citations

Lamotrigine substitution study: evidence for synergism with sodium valproate?

1997 • 365 citations

DEATH DURING THERAPEUTIC STARVATION

1968 • 360 citations

Valproic acid hepatic fatalities. III. U.S. experience since 1986

1996 • 329 citations

Chronic Antiepileptic Toxicity: A Review

1975 • 286 citations

Randomised comparative monotherapy trial of phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed childhood epilepsy

1996 • 264 citations

Phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed adult epilepsy: a randomised comparative monotherapy trial.

1995 • 257 citations

Monotherapy or Polytherapy for Epilepsy?

1998 • 251 citations

Vigabatrin-associated retinal cone system dysfunction

1998 • 249 citations

A double-blind controlled clinical trial: oxcarbazepine versus sodium valproate in adults with newly diagnosed epilepsy

1997 • 224 citations

A multicentre comparative trial of sodium valproate and carbamazepine in adult onset epilepsy. Adult EPITEG Collaborative Group.

1994 • 194 citations

Reduction in polypharmacy for epilepsy.

1979 • 192 citations

Vigabatrin vs Carbamazepine Monotherapy in Patients With Newly Diagnosed Epilepsy

1995 • 181 citations

A MULTICENTRE COMPARATIVE TRIAL OF SODIUM VALPROATE AND CARBAMAZEPINE IN PAEDIATRIC EPILEPSY

1995 • 168 citations

One drug for epilepsy.

1978 • 163 citations

Prognosis in Childhood Epilepsy

1972 • 161 citations

Topiramate Monotherapy for Partial Onset Seizures

1997 • 159 citations

A randomised open multicentre comparative trial of lamotrigine and carbamazepine as monotherapy in patients with newly diagnosed or recurrent epilepsy

1996 • 145 citations

Reduction of Two‐Drug Therapy in Intractable Epilepsy

1983 • 133 citations

Reappraisal of Polytherapy in Epilepsy: A Critical Review of Drug Load and Adverse Effects

1997 • 132 citations

Neuroactive kynurenines in Lyme borreliasis

1992 • 125 citations

ONE DRUG (PHENYTOIN) IN THE TREATMENT OF EPILEPSY

1976 • 118 citations

Safety and Efficacy of Divalproex Sodium Monotherapy in Partial Epilepsy

1997 • 113 citations

Paradoxical Intoxication,:A Complication of Anticonvulsant Administration

1975 • 113 citations

Adverse Reactions to Antiepileptic Drugs: A Multicenter Survey of Clinical Practice

1986 • 106 citations

Monotherapy with Valproate in Primary Generalized Epilepsies

1987 • 102 citations

Unnecessary polypharmacy for epilepsy.

1977 • 101 citations

DRUG TREATMENT OF EPILEPSY

1978 • 101 citations

Removal of sedative‐hypnotic antiepileptic drugs from the regimens of patients with intractable epilepsy

1983 • 92 citations

Gabapentin monotherapy: II. A 26-week, double-blind, dose-controlled, multicenter study of conversion from polytherapy in outpatients with refractory complex partial or secondarily generalized seizures

1997 • 91 citations

Gabapentin monotherapy: I. An 8-day, double-blind, dose controlled, multicenter study in hospitalized patients with refractory complex partial or secondarily generalized seizures

1997 • 87 citations

Vigabatrin vs. carbamazepine monotherapy in newly diagnosed focal epilepsy: a randomized response conditional cross-over study

1996 • 85 citations

Monotherapy or Polytherapy for Epilepsy Revisited: A Quantitative Assessment

1995 • 83 citations

Carbamazepine as a single drug in the treatment of epilepsy. A prospective study of serum levels and seizure control.

1978 • 73 citations

The distribution of plasma phenytoin levels in epileptic patients

1970 • 64 citations

Pharmacologic interactions between valproate and other drugs

1988 • 48 citations

Pharmacogenetics and drug interactions: role in antiepileptic-drug-induced teratogenesis.

1992 • 44 citations

Phenytoin and carbamazepine, alone and in combination

1987 • 43 citations

Statistical Analysis of Pharmacokinetic Parameters in Epileptic Patients Chronically Treated with Anti-Epileptic Drugs

1975 • 40 citations

Serum levels of anticonvulsant drugs interpretation and clinical value

1980 • 38 citations

[Monotherapy with clobazam in epilepsies in children].

1983 • 30 citations

Newer antiepileptic drugs as monotherapy

1996 • 18 citations

Proposals on Antiepileptic Pharmacotherapy for Use in Developing Countries¹

1976 • 14 citations

Add-on trial of lamotrigine followed by withdrawal of concomitant medication and stabilization on monotherapy

1996 • 5 citations

A Comment on the Efficacy of Valproate in the Treatment of Partial Seizures

1994 • 4 citations