IL-15 enhances the function and inhibits CD95/Fas-induced apoptosis of human CD4+ and CD8+ effector-memory T cells

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection

1994 • 1,899 citations

Vigorous HIV-1-Specific CD4 ⁺ T Cell Responses Associated with Control of Viremia

1997 • 1,868 citations

Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice

2000 • 1,578 citations

Quantitation of HIV-1-Specific Cytotoxic T Lymphocytes and Plasma Load of Viral RNA

1998 • 1,426 citations

Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

1994 • 1,423 citations

IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation

1998 • 1,293 citations

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

1998 • 1,262 citations

Skewed maturation of memory HIV-specific CD8 T lymphocytes

2001 • 1,025 citations

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.

1994 • 1,008 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

Control of Homeostasis of CD8 ⁺ Memory T Cells by Opposing Cytokines

2000 • 847 citations

The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15

1995 • 760 citations

Qualitative Analysis of Immune Function in Patients with the Acquired Immunodeficiency Syndrome

1985 • 737 citations

Biochemical Mechanisms of IL-2–Regulated Fas-Mediated T Cell Apoptosis

1998 • 644 citations

Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor.

1995 • 627 citations

Fas transduces activation signals in normal human T lymphocytes.

1993 • 521 citations

Cutting Edge: Requirement for IL-15 in the Generation of Primary and Memory Antigen-Specific CD8 T Cells

2002 • 519 citations

Impaired Production of Lymphokines and Immune (Gamma) Interferon in the Acquired Immunodeficiency Syndrome

1984 • 513 citations

Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood.

1992 • 510 citations

CD8 naive T cell counts decrease progressively in HIV-infected adults.

1995 • 495 citations

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 475 citations

Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis

1996 • 452 citations

RETRACTED: Uncoupling IL-2 Signals that Regulate T Cell Proliferation, Survival, and Fas-Mediated Activation-Induced Cell Death

1999 • 443 citations

Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals.

1995 • 438 citations

IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice

2000 • 419 citations

Cytokine-induced survival of activated T cellsin vitroandin vivo

1998 • 395 citations

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

1995 • 372 citations

Functional Characterization of the Human Interleukin-15 Receptor αChain and Close Linkage of IL15RA and IL2RA Genes

1995 • 363 citations

Fatal Leukemia in Interleukin 15 Transgenic Mice Follows Early Expansions in Natural Killer and Memory Phenotype Cd8+ T Cells

2001 • 362 citations

Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro.

1995 • 357 citations

Interleukin-15 protects from lethal apoptosis in vivo

1997 • 339 citations

Induction and regulation of IL-15 expression in murine macrophages.

1996 • 327 citations

Natural killer cells from human immunodeficiency virus (HIV)-infected individuals are an important source of CC-chemokines and suppress HIV-1 entry and replication in vitro.

1998 • 274 citations

IL-15, a novel T cell growth factor that shares activities and receptor components with IL-2

1995 • 221 citations

IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8⁺memory T cells

2002 • 199 citations

Fas-mediated apoptosis of CD4+ and CD8+ T cells from human immunodeficiency virus-infected persons: differential in vitro preventive effect of cytokines and protease antagonists

1996 • 189 citations

Activation of naive and memory T cells by interleukin-15

1996 • 183 citations

Induction of IL-15 messenger RNA and protein in human blood-derived dendritic cells: a role for IL-15 in attraction of T cells.

1997 • 167 citations

Increased CD95/Fas-Induced Apoptosis of HIV-Specific CD8+ T Cells

2001 • 163 citations

Natural Killer Cells from HIV-1+ Patients Produce C-C Chemokines and Inhibit HIV-1 Infection

1998 • 160 citations

Activation of naive and memory T cells by interleukin-15

1996 • 141 citations

Loss of CD28 expression on CD8+ T cells is induced by IL-2 receptor γ chain signalling cytokines and type I IFN, and increases susceptibility to activation-induced apoptosis

2000 • 141 citations

Interleukin-15 mRNA Is Expressed by Human Keratinocytes, Langerhans Cells, and Blood-Derived Dendritic Cells and Is Downregulated by Ultraviolet B Radiation

1996 • 129 citations

IL-15 enhances immune functions during HIV infection.

1997 • 129 citations

Overexpression of IL-15 In Vivo Increases Antigen-Driven Memory CD8+ T Cells Following a Microbe Exposure

2002 • 120 citations

Cytokine interactions in human immunodeficiency virus-infected individuals: roles of interleukin (IL)-2, IL-12, and IL-15.

1995 • 113 citations

IL-15 stimulates the expansion of AIDS virus-specific CTL.

1996 • 112 citations

Functionally distinct CD8+ memory T cell subsets in persistent EBV infection are differentiated by migratory receptor expression

2000 • 95 citations

The role of the common cytokine receptor gamma-chain in regulating IL-2-dependent, activation-induced CD8+ T cell death.

1999 • 87 citations

Interleukin-15 in HIV infection: immunological and virological interactions in antiretroviral-naive and -treated patients

2002 • 63 citations

Distribution of IL-15 receptor alpha-chains on human peripheral blood mononuclear cells and effect of immunosuppressive drugs on receptor expression.

1996 • 63 citations

Role of IL-15 in HIV-1-associated hypergammaglobulinaemia

1997 • 51 citations

Evidence for the Involvement of LCK and MAP Kinase (ERK-1) in the Signal Transduction Mechanism of Interleukin-15

1997 • 42 citations

Activation, survival and apoptosis of CD45RO⁺ and CD45RO⁻ T cells of human immunodeficiency virus‐infected individuals: effects of interleukin‐15 and comparison with interleukin‐2

1999 • 29 citations

CD69 expression reliably predicts the anti-CD3-induced proliferative response of lymphocytes from human immunodeficiency virus type 1-infected patients

1997 • 26 citations

Uncoupling IL-2 Signals that Regulate T Cell Proliferation, Survival, and Fas-Mediated Activation-Induced Cell Death

2009 • 24 citations

BAG-1 and Bcl-2 in IL-2 Signaling

1998 • 16 citations