Opposing Effects of Anti-Activation-Inducible Lymphocyte- Immunomodulatory Molecule/Inducible Costimulator Antibody on the Development of Acute Versus Chronic Graft-Versus-Host Disease

Guide for the Care and Use of Laboratory Animals

2011 • 15,863 citations

Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation

1999 • 1,912 citations

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

INDUCTION OF TH1 AND TH2 CD4⁺T CELL RESPONSES:The Alternative Approaches

1997 • 1,464 citations

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

1999 • 1,418 citations

The Role of Chemokine Receptors in Primary, Effector, and Memory Immune Responses

2000 • 1,077 citations

Complexities of CD28/B7: CTLA-4 Costimulatory Pathways in Autoimmunity and Transplantation

2001 • 1,032 citations

ICOS co-stimulatory receptor is essential for T-cell activation and function

2001 • 902 citations

T-cell co-stimulation through B7RP-1 and ICOS

1999 • 758 citations

ICOS is essential for effective T-helper-cell responses

2001 • 666 citations

ICOS is critical for CD40-mediated antibody class switching

2001 • 646 citations

Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation.

1993 • 569 citations

Long-Term Human B Cell Lines Dependent on Interleukin-4 and antibody to CD40

1991 • 554 citations

CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.

1995 • 532 citations

Identification of an Alternative CTLA-4 Ligand Costimulatory for T Cell Activation

1993 • 517 citations

The CD28-Related Molecule ICOS Is Required for Effective T Cell–Dependent Immune Responses

2000 • 507 citations

B7h, a Novel Costimulatory Homolog of B7.1 and B7.2, Is Induced by TNFα

1999 • 440 citations

Mouse Inducible Costimulatory Molecule (ICOS) Expression Is Enhanced by CD28 Costimulation and Regulates Differentiation of CD4+ T Cells

2000 • 423 citations

CD4 T Cell Cytokine Differentiation: The B Cell Activation Molecule, OX40 Ligand, Instructs CD4 T Cells to Express Interleukin 4 and Upregulates Expression of the Chemokine Receptor, Blr-1

1998 • 358 citations

Graft-versus-host reactions: clues to the etiopathology of a spectrum of immunological diseases

1984 • 354 citations

The paradigm of Th1 and Th2 cytokines

1999 • 313 citations

CD28 costimulation promotes the production of Th2 cytokines.

1997 • 299 citations

Graft-vs.-Host Disease

1997 • 262 citations

Critical Contribution of Ox40 Ligand to T Helper Cell Type 2 Differentiation in Experimental Leishmaniasis

2000 • 235 citations

Kinetics of Th1 and Th2 cytokine production during the early course of acute and chronic murine graft-versus-host disease. Regulatory role of donor CD8+ T cells.

1995 • 232 citations

Cutting Edge: Identification of GL50, a Novel B7-Like Protein That Functionally Binds to ICOS Receptor

2000 • 230 citations

Inducible Costimulator Protein (Icos) Controls T Helper Cell Subset Polarization after Virus and Parasite Infection

2000 • 206 citations

CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system.

1995 • 204 citations

The Th1/Th2 balance in autoimmunity

1995 • 198 citations

LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production.

1998 • 197 citations

How the MHC selects Th1/Th2 immunity

1998 • 178 citations

Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand

2000 • 176 citations

B7-CD28/CTLA-4 costimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigens.

1997 • 172 citations

A sensitive ELISPOT assay to detect low-frequency human T lymphocytes

1997 • 170 citations

T-cell interactions in autoimmunity

1988 • 163 citations

Cutting Edge: LFA-1 Interaction with ICAM-1 and ICAM-2 Regulates Th2 Cytokine Production

1998 • 160 citations

Preferential dependence of autoantibody production in murine lupus on CD86 costimulatory molecule

1995 • 156 citations

Roles of IL-4 and IL-12 in the development of lupus in NZB/W F1 mice.

1997 • 153 citations

The antigen dose determines T helper subset development by regulation of CD40 ligand

2000 • 134 citations

Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS

2000 • 132 citations

LICOS, a primordial costimulatory ligand?

2000 • 109 citations

Differential effect of CTLA4Ig on murine graft-versus-host disease (GVHD) development: CTLA4Ig prevents both acute and chronic GVHD development but reverses only chronic GVHD.

1996 • 91 citations

Murine chronic graft-versus-host disease as a model for lupus nephritis.

1988 • 90 citations

Immunodeficiency in graft-versus-host disease. I. Mechanism of immune suppression.

1988 • 80 citations

Induction of unresponsiveness and impaired T cell expansion by staphylococcal enterotoxin B in CD28-deficient mice.

1996 • 78 citations

CD28 Costimulation Accelerates IL-4 Receptor Sensitivity and IL-4-Mediated Th2 Differentiation

1999 • 78 citations

Protection against lethal toxic shock by targeted disruption of the CD28 gene.

1996 • 72 citations

CD28 dependence of T cell differentiation to IL-4 production varies with the particular type 2 immune response.

1997 • 70 citations

Cutting Edge: The Related Molecules CD28 and Inducible Costimulator Deliver Both Unique and Complementary Signals Required for Optimal T Cell Activation

2001 • 62 citations

T Cell Activation and Polarization by DC1 and DC2

2000 • 62 citations

Studies on Murine IgE with Monoclonal Antibodies

1988 • 57 citations

Acute graft-versus-host reaction can be aborted by blockade of costimulatory molecules.

1995 • 46 citations

Toxic shock syndrome toxin-1-induced death is prevented by CTLA4Ig.

1996 • 46 citations

AILIM/ICOS: a novel lymphocyte adhesion molecule

2000 • 44 citations

AILIM/ICOS: Its Expression and Functional Analysis with Monoclonal Antibodies

2001 • 31 citations

A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor

1995 • 27 citations

Stat6 activation and Th2 cell proliferation driven by CD28 signals

2000 • 25 citations

CD28 knockout mice as a useful clue to examine the pathogenesis of chronic graft-versus-host reaction

2000 • 10 citations

Roles of IL-4 and IL-12 in the development of lupus in NZB/W F[1] mice

1997 • 9 citations