Genetic causes of mild hyperhomocysteinemia in patients with premature occlusive coronary artery diseases

Hyperhomocysteinemia: An Independent Risk Factor for Vascular Disease

1991 • 2,191 citations

Vitamin Status and Intake as Primary Determinants of Homocysteinemia in an Elderly Population

1993 • 1,920 citations

Plasma Homocysteine as a Risk Factor for Vascular Disease

1997 • 1,770 citations

A Prospective Study of Plasma Homocyst(e)ine and Risk of Myocardial Infarction in US Physicians

1992 • 1,686 citations

Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations

1996 • 1,423 citations

Association between Plasma Homocysteine Concentrations and Extracranial Carotid-Artery Stenosis

1995 • 1,244 citations

Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men

1995 • 899 citations

Heterozygosity for Homocystinuria in Premature Peripheral and Cerebral Occlusive Arterial Disease

1985 • 739 citations

Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.

1996 • 670 citations

Serum Total Homocysteine and Coronary Heart Disease

1995 • 668 citations

Prospective Study of Coronary Heart Disease Incidence in Relation to Fasting Total Homocysteine, Related Genetic Polymorphisms, and B Vitamins

1998 • 616 citations

Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease.

1991 • 615 citations

Methylenetetrahydrofolate Reductase Polymorphism, Plasma Folate, Homocysteine, and Risk of Myocardial Infarction in US Physicians

1996 • 496 citations

Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia.

1995 • 421 citations

Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project

1997 • 404 citations

Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders

1996 • 399 citations

Vitamin status and intake as primary determinants of homocysteinemia in an elderly population

1993 • 386 citations

A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians

1992 • 329 citations

Correlation of a Common Mutation in the Methylenetetrahydrofolate Reductase Gene With Plasma Homocysteine in Patients With Premature Coronary Artery Disease

1997 • 234 citations

Human Methionine Synthase

1997 • 181 citations

Methylenetetrahydrofolate Reductase Gene and Coronary Artery Disease

1997 • 169 citations

Cloning, mapping and RNA analysis of the human methionine synthase gene

1996 • 144 citations

The 677C→T mutation in the methylenetetrahydrofolate reductase gene: associations with plasma total homocysteine levels and risk of coronary atherosclerotic disease

1997 • 139 citations

Defects in human methionine synthase in cblG patients

1996 • 115 citations

Molecular basis of cystathionine β-synthase deficiency in pyridoxine responsive and nonresponsive homocystinuria

1993 • 98 citations

A common mutation in methylenetetrahydrofolate reductase gene is not a major risk of coronary artery disease or myocardial infarction

1997 • 92 citations

Excess Prevalence of Fasting and Postmethionine-Loading Hyperhomocysteinemia in Stable Renal Transplant Recipients

1997 • 88 citations

High frequency (71%) of cystathionine β-synthase mutation G307S in Irish homocystinuria patients

1995 • 80 citations

Molecular and biochemical approaches in the identification of heterozygotes for homocystinuria

1996 • 63 citations

A missense mutation (I278T) in the cystathionine beta-synthase gene prevalent in pyridoxine-responsive homocystinuria and associated with mild clinical phenotype.

1995 • 60 citations

Hyperhomocysteinemia in premature arterial disease: examination of cystathionine β-synthase alleles at the molecular level

1995 • 57 citations

Estimates of heritability of plasma homocyst(e)ine levels in aging adult male twins

1991 • 54 citations

Plasma Homocysteine and Methionine Tolerance in Early-Onset Vascular Disease

1989 • 29 citations