Cathepsin D Is a Potential Serum Marker for Poor Prognosis in Glioma Patients

Molecular mechanisms of glioma invasiveness: the role of proteases

2003 • 823 citations

Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells.

1995 • 428 citations

Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis

2002 • 252 citations

Prognostic molecular markers in early breast cancer

2004 • 245 citations

In vitro degradation of extracellular matrix with Mr 52,000 cathepsin D secreted by breast cancer cells.

1988 • 242 citations

Cathepsin B expression and localization in glioma progression and invasion.

1994 • 217 citations

Cathepsin-D in primary breast cancer: prognostic evaluation involving 2810 patients

1998 • 201 citations

Molecular Classification and Survival Prediction in Human Gliomas Based on Proteome Analysis

2004 • 163 citations

Proteases in brain tumour progression

2003 • 153 citations

Cathepsin B immunohistochemical staining in tumor and endothelial cells is a new prognostic factor for survival in patients with brain tumors.

1999 • 121 citations

Cathepsin D in breast cancer cells can digest extracellular matrix in large acidic vesicles.

1990 • 116 citations

Gene-Environment Interaction Signatures by Quantitative mRNA Profiling in Exfoliated Buccal Mucosal Cells

2004 • 106 citations

Proteases and their inhibitors in human brain tumours: a review.

1998 • 106 citations

Cathepsin D in the malignant progression of neoplastic diseases (review).

1992 • 102 citations

Activation of cathepsin B, secreted by a colorectal cancer cell line requires low pH and is mediated by cathepsin D

1996 • 92 citations

Lysosomal enzymes, cathepsins in brain tumour invasion.

2002 • 83 citations

Highly consistent genetic alterations in childhood adrenocortical tumours detected by comparative genomic hybridization

1999 • 78 citations

Transfected cathepsin D stimulates high density cancer cell growth by inactivating secreted growth inhibitors.

1995 • 66 citations

Isolation of Novel Mouse Genes Differentially Expressed in Brain Using cDNA Microarray

2000 • 66 citations

Cathepsin D inactivates cysteine proteinase inhibitors cystatins

1988 • 61 citations

Expression of cathepsin D during the progression of human gliomas

1996 • 50 citations

Expression of Adhesion Factors and Degrading Proteins in Primary and Secondary Glioblastomas and Their Precursor Tumors

1998 • 39 citations

Adhesive and invasive features in gliomas

2000 • 27 citations

THE CHARACTERIZATION OF NUCLEAR-DNA CONTENT, THE PROLIFERATIVE ACTIVITY AND THE IMMUNOHISTOCHEMICAL EXPRESSION OF GFAP, VIM, LEU-7, S-100, P53 AND CATHEPSIN-D IN HUMAN GLIOBLASTOMA MULTIFORMES (HGBMS) VERSUS HUMAN GBM CELL-LINES GRAFTED INTO THE BRAINS OF NUDE-MICE

1995 • 15 citations