An Official American Thoracic Society Clinical Practice Guideline: The Diagnosis of Intensive Care Unit–acquired Weakness in Adults

The Measurement of Observer Agreement for Categorical Data

1977 • 70,424 citations

Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial

2009 • 2,957 citations

Daily Interruption of Sedative Infusions in Critically Ill Patients Undergoing Mechanical Ventilation

2000 • 2,838 citations

Functional Disability 5 Years after Acute Respiratory Distress Syndrome

2011 • 2,405 citations

Long-Term Cognitive Impairment after Critical Illness

2013 • 2,324 citations

One-Year Outcomes in Survivors of the Acute Respiratory Distress Syndrome

2003 • 2,141 citations

Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial

2008 • 1,894 citations

Paresis Acquired in the Intensive Care Unit<SUBTITLE>A Prospective Multicenter Study</SUBTITLE>

2002 • 1,389 citations

Grading quality of evidence and strength of recommendations for diagnostic tests and strategies

2008 • 1,366 citations

Early intensive care unit mobility therapy in the treatment of acute respiratory failure*

2008 • 1,269 citations

Critical care and the global burden of critical illness in adults

2010 • 1,151 citations

Post-Hospital Syndrome — An Acquired, Transient Condition of Generalized Risk

2013 • 1,099 citations

Early exercise in critically ill patients enhances short-term functional recovery*

2009 • 951 citations

Early activity is feasible and safe in respiratory failure patients*

2006 • 835 citations

Early Physical Medicine and Rehabilitation for Patients With Acute Respiratory Failure: A Quality Improvement Project

2010 • 690 citations

Acquired Weakness, Handgrip Strength, and Mortality in Critically Ill Patients

2008 • 671 citations

Insulin therapy protects the central and peripheral nervous system of intensive care patients

2005 • 624 citations

Neuromuscular dysfunction acquired in critical illness: a systematic review

2007 • 600 citations

A framework for diagnosing and classifying intensive care unit-acquired weakness

2009 • 590 citations

Peripheral Nerve Function in Sepsis and Multiple Organ Failure

1991 • 579 citations

An Official ATS Statement: Grading the Quality of Evidence and Strength of Recommendations in ATS Guidelines and Recommendations

2006 • 575 citations

Physical Complications in Acute Lung Injury Survivors

2013 • 536 citations

The Adult Respiratory Distress Syndrome Cognitive Outcomes Study

2012 • 536 citations

Critical illness myopathy and neuropathy

1996 • 503 citations

Quality of life in adult survivors of critical illness: A systematic review of the literature

2005 • 499 citations

Respiratory weakness is associated with limb weakness and delayed weaning in critical illness*

2007 • 496 citations

Hospital Volume and the Outcomes of Mechanical Ventilation

2006 • 491 citations

Epidemiology and Outcomes of Acute Lung Injury

2007 • 475 citations

Two-Year Outcomes, Health Care Use, and Costs of Survivors of Acute Respiratory Distress Syndrome

2006 • 450 citations

Mobilizing Patients in the Intensive Care Unit

2008 • 449 citations

Critical illness polyneuropathy: risk factors and clinical consequences. A cohort study in septic patients

2001 • 397 citations

ICU-Acquired Weakness

2007 • 381 citations

Risk factors for the development of polyneuropathy and myopathy in critically ill patients

2001 • 357 citations

Does ICU-acquired paresis lengthen weaning from mechanical ventilation?

2004 • 354 citations

Impact of Intensive Insulin Therapy on Neuromuscular Complications and Ventilator Dependency in the Medical Intensive Care Unit

2006 • 353 citations

Electrical muscle stimulation prevents critical illness polyneuromyopathy: a randomized parallel intervention trial

2010 • 299 citations

The Role of Polyneuropathy in Motor Convalescence After Prolonged Mechanical Ventilation

1995 • 298 citations

Management of Patients Requiring Prolonged Mechanical Ventilation

2017 • 293 citations

Effect of tolerating macronutrient deficit on the development of intensive-care unit acquired weakness: a subanalysis of the EPaNIC trial

2013 • 288 citations

Interobserver agreement of medical research council sum‐score and handgrip strength in the intensive care unit

2011 • 285 citations

Expectations and outcomes of prolonged mechanical ventilation*

2009 • 282 citations

Direct muscle stimulation in acute quadriplegic myopathy

1997 • 262 citations

Acute quadriplegia and loss of muscle myosin in patients treated with nondepolarizing neuromuscular blocking agents and corticosteroids: Mechanisms at the cellular and molecular levels

2000 • 255 citations

Early signs of critical illness polyneuropathy in ICU patients with systemic inflammatory response syndrome or sepsis

2000 • 237 citations

Guillain-Barré syndrome

2003 • 229 citations

Presence and severity of intensive care unit-acquired paresis at time of awakening are associated with increased intensive care unit and hospital mortality*

2009 • 229 citations

Early development of critical illness myopathy and neuropathy in patients with severe sepsis

2006 • 224 citations

Feasibility and safety of early combined cognitive and physical therapy for critically ill medical and surgical patients: the Activity and Cognitive Therapy in ICU (ACT-ICU) trial

2013 • 220 citations

Long-term outcome in patients with critical illness myopathy or neuropathy: the Italian multicentre CRIMYNE study

2008 • 215 citations

Intensive Care Unit–acquired Weakness

2012 • 206 citations

Critical illness polyneuropathy in multiple organ dysfunction syndrome and weaning from the ventilator

1996 • 190 citations

Manual muscle strength testing of critically ill patients: feasibility and interobserver agreement

2011 • 190 citations

Critical illness polyneuromyopathy: the electrophysiological components of a complex entity

2003 • 188 citations

Risk factors for critical illness polyneuromyopathy

2005 • 185 citations

Physical therapy utilization in intensive care units: Results from a national survey

2009 • 180 citations

Prolonged acute mechanical ventilation, hospital resource utilization, and mortality in the United States

2008 • 177 citations

Acute myopathy after liver transplantation

1998 • 164 citations

Simplified electrophysiological evaluation of peripheral nerves in critically ill patients: the Italian multi-centre CRIMYNE study

2007 • 157 citations

Effects of early treatment with immunoglobulin on critical illness polyneuropathy following multiple organ failure and gram-negative sepsis

1997 • 156 citations

Patterns of neurophysiological abnormality in prolonged critical illness

1998 • 156 citations

Acquired neuromuscular disorders in critically ill patients: a systematic review

1998 • 152 citations

Electrophysiologic studies in critical illness associated weakness: myopathy or neuropathy – a reappraisal

2001 • 151 citations

Predisposing factors for critical illness polyneuromyopathy in a multidisciplinary intensive care unit

2008 • 141 citations

Origin of ICU acquired paresis determined by direct muscle stimulation

2005 • 140 citations

Interventions to Improve the Physical Function of ICU Survivors

2013 • 138 citations

Clinical predictive value of manual muscle strength testing during critical illness: an observational cohort study

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Physical inactivity and muscle weakness in the critically ill

2009 • 118 citations

Intensive care unit-acquired neuromyopathy and corticosteroids in survivors of persistent ARDS

2008 • 116 citations

Steroid-induced myopathy in patients intubated due to exacerbation of chronic obstructive pulmonary disease

2004 • 105 citations

Skeletal muscle dysfunction in critical care: Wasting, weakness, and rehabilitation strategies

2010 • 99 citations

Legacy of intensive care unit-acquired weakness

2009 • 97 citations

Incidence and onset of critical illness polyneuropathy in patients with septic shock

2000 • 92 citations

Caspase and calpain activation both contribute to sepsis-induced diaphragmatic weakness

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Improving Post–Intensive Care Unit Neuropsychiatric Outcomes

2012 • 85 citations

ICU-acquired weakness: what is preventing its rehabilitation in critically ill patients?

2012 • 71 citations

Single-fiber electromyography, nerve conduction studies, and conventional electromyography in patients with critical-illness polyneuropathy: Evidence for a lesion of terminal motor axons

1997 • 68 citations

Sepsis and Catecholamine Support are the Major Risk Factors for Critical Illness Polyneuropathy after Open Heart Surgery1

2000 • 63 citations

Physical Therapy Management and Patient Outcomes Following ICU–Acquired Weakness

2011 • 61 citations

Benefits of intensive insulin therapy on neuromuscular complications in routine daily critical care practice: a retrospective study

2009 • 59 citations

The role of future longitudinal studies in ICU survivors: understanding determinants and pathophysiology of weakness and neuromuscular dysfunction

2007 • 40 citations

Critical illness polyneuropathy: a new iatrogenically induced syndrome after cardiac surgery?

1997 • 37 citations

The neurological examination in the assessment of polyneuropathy in mechanically ventilated patients

1997 • 20 citations

Double-stranded RNA-dependent protein kinase activation modulates endotoxin-induced diaphragm weakness

2010 • 20 citations

Toward a more efficient and effective neurologic examination for the 21st century*

2005 • 14 citations

Acute Lung Injury and Acute Respiratory Distress Syndrome Requiring Tracheal Intubation and Mechanical Ventilation in the Intensive Care Unit

2012 • 9 citations

Outcomes after ARDS: a distinct group in the spectrum of disability after complex and protracted critical illness.

2013 • 7 citations

Limited value of physical examinations in upper respiratory illness: account of personal experience and survey of doctors’ views

2009 • 2 citations